A Randomized Formula Controlled Trial of Bifidobacterium lactis and Streptococcus thermophilus for Prevention of Antibiotic-Associated Diarrhea in Infants
Abstract
GOALS: This clinical trial was carried out to determine whether oral treatment with a commercial probiotic formula containing Bifidobacterium lactis and Streptococcus thermophilus would reduce the frequency of antibiotic-associated diarrhea (AAD) in infants. STUDY: In this double-bind formula controlled study, 80 infants, 6 to 36 months of age, were randomly assigned to receive a commercial formula containing 10 viable cells of B. lactis and 10 viable cells of S. thermophilus at the initiation of antibiotics for a duration of 15 days. The infants were assessed daily for formula intake, stool frequency, and stool consistency for a total duration of 30 days. Seventy-seven infants received nonsupplemented formula for the entire duration. RESULTS: There was a significant difference in the incidence of AAD in the children receiving probiotic-supplemented formula (16%) than nonsupplemented formula (31%). CONCLUSIONS: The present study shows that prevention against AAD in infants was obtained by oral treatment with daily dose of B. lactis and S. thermophilus.
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Different bifidobacteria species, mostly combined with St. thermophilus and/or Lb. acidophilus, have been shown to be effective in the prevention and treatment of antibiotic associated diarrhea.
“Different bifidobacteria species (B.animalis subsp.lactis, B. bifidum, or B. infantis), mostly combined with St. thermophilus and/or Lb. acidophilus, have been shown to be effective in the prevention and treatment of antibiotic associated diarrhea [129,130]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [129]
Cites
The indigenous gastrointestinal microflora
Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · see citing works
Schell, M. A., Karmirantzou, M., Snel, ., Vilanova, D., Berger, B. W., Pessi, G., Zwahlen, M.-C., Desiere, F., Peer Bork, B., Delley, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527599 · Cited by 942 · see citing works
Income inequality and population health
Mackenbach, J. P. (2002) · BMJ · doi:10.1136/bmj.324.7328.1 · Cited by 850 · see citing works
Bernet‐Camard, M., Brassart, D., Neeser, J., & Servin, A. L. (1994) · Gut · doi:10.1136/gut.35.4.483 · Cited by 751 · see citing works
Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis
D'Souza, A. L., Rajkumar, C., Cooke, J., & Bulpitt, C. J. (2002) · BMJ · doi:10.1136/bmj.324.7350.1361 · Cited by 664 · see citing works
Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: A prospective study
Surawicz, C. M., Elmer, G. W., Speelman, P., McFarland, L. V., Chinn, J., & van Belle, G. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91613-2 · Cited by 570 · see citing works
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
Vanderhoof, J. A., Whitney, D. B., Antonson, D. L., Hanner, T. L., Lupo, J. V., & Young, R. J. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70053-3 · Cited by 536 · see citing works
Lactic acid bacteria, their metabolic products and interference with microbial growth
Vandenbergh, P. A. (1993) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1993.tb00020.x · Cited by 475 · see citing works
The Lactobacillus and Bifidobacterium microflora of the human intestine: composition and succession.
Reuter, G. (2001) · PubMed · Cited by 417 · see citing works
Antibiotic-Associated Diarrhea
Bartlett, J. G. (1992) · Clinical Infectious Diseases · doi:10.1093/clind/15.4.573 · Cited by 414 · see citing works
Liévin, V, Peiffer, I., Hudault, S., Rochat, F., Brassart, D., Neeser, J.-R., & Servin, A. L. (2000) · Gut · doi:10.1136/gut.47.5.646 · Cited by 397 · see citing works
Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea
Cremonini, F., Caro, S. D., Nista, E. C., Bartolozzi, F., Capelli, G., Gasbarrini, A., & Gasbarrini, A. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01318.x · Cited by 385 · see citing works
Schiffrin, E., Brassart, D., Servin, A., Rochat, F., & Donnet-Hughes, A. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.515s · Cited by 354 · see citing works
Diagnosis and Treatment of Clostridium difficile Colitis
Fekety, R. (1993) · JAMA · doi:10.1001/jama.1993.03500010081036 · Cited by 342 · see citing works
RELAPSING CLOSTRIDIUM DIFFICILE ENTEROCOLITIS CURED BY RECTAL INFUSION OF HOMOLOGOUS FAECES
Schwan, A. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90753-5 · Cited by 199 · see citing works
Wunderlich, P. F., Braun, L., Fumagalli, I. A. L., D’Apuzzo, V., Heim, F., Karly, M., Lodi, R., Politta, G., Vonbank, F., & Zeltner, L. (1989) · Journal of International Medical Research · doi:10.1177/030006058901700405 · Cited by 177 · see citing works
Taxonomy and Ecology of Bifidobacteria
MITSUOKA, T. (1984) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.3.1_11 · Cited by 171 · see citing works
Beta-Lactam Antibiotic Therapy in Febrile Granulocytopenic Patients
Winston, D. J., Ho, W. G., Bruckner, D. A., et al. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-11-849 · Cited by 162 · see citing works
Binding of Aflatoxin B1 to Bifidobacteria In Vitro
Oatley, J. T., Rarick, M., Ji, G. E., & Linz, J. E. (2000) · Journal of Food Protection · doi:10.4315/0362-028x-63.8.1133 · Cited by 150 · see citing works
Asahara, T., Nomoto, K., Shimizu, K., Watanuki, M., & Tanaka, R. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01461.x · Cited by 147 · see citing works
Shu, Q., Lin, H., Rutherfurd, K. J., Fenwick, S., Prasad, J., Gopal, P. K., & Gill, H. S. (2000) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2000.tb02486.x · Cited by 116 · see citing works
Corthier, G., Dubos, F., & Raibaud, P. (1985) · Applied and Environmental Microbiology · doi:10.1128/aem.49.1.250-252.1985 · Cited by 96 · see citing works
Sullivan, Å. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg346 · Cited by 71 · see citing works
Silva, A. M., Bambirra, E. A., Oliveira, A. D. L., Souza, P. P., Gomes, D. A., Vieira, E., & Nicoli, J. R. (1999) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1999.00674.x · Cited by 70 · see citing works
Self-citationNeumann, E., de Oliveira, M. A. P., Cabral, C. M., Moura, L. N., Nicoli, J. R., Vieira, E., Cara, D. C., Gi, P., & Vieira, L. Q. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998001200009 · Cited by 70 · see citing works
Self-citationLee, Y.-J., Yu, W.-K., & Heo, T. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(02)00389-8 · Cited by 62 · see citing works
Lee, J., Ametani, A., Enomoto, A., et al. (1993) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.57.2127 · Cited by 52 · see citing works
Schwalbe, R. A., Sparling, P. F., & Cannon, J. G. (1985) · Infection and Immunity · doi:10.1128/iai.49.1.250-252.1985 · Cited by 48 · see citing works
Effect of yogurt feeding on the small and large intestine associated lymphoid cells in mice
Perdigón, G., Rachid, M., Budeguer, M. V. D., et al. (1994) · Journal of Dairy Research · doi:10.1017/s002202990002848x · Cited by 45 · see citing works
Ys, K., Yang, S. J., Koo, H. C., Bae, W. K., Kim, J. Y., Park, J., Baek, Y. J., & Park, Y. H. (2001) · Journal of Food Protection · doi:10.4315/0362-028x-64.11.1667 · Cited by 43 · see citing works
Sasaki, T., SAMEGAI, Y., & NAMIOKA, S. (1996) · Journal of Veterinary Medical Science · doi:10.1292/jvms.58.85 · Cited by 12 · see citing works
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Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works
McFarland, L. V. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00465.x · Cited by 872 · see citing works
Newberry, S. J. (2012) · JAMA · doi:10.1001/jama.2012.3507 · Cited by 870 · see citing works
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Goldenberg, J. Z., Ma, S. S., Saxton, J. D., Martzen, M. R., Vandvik, P. O., Thorlund, K., Guyatt, G. H., & Johnston, B. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub3 · Cited by 741 · see citing works
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Goldenberg, J. Z., Yap, C., Lytvyn, L., Lo, C. K.-F., Beardsley, J., Mertz, D., & Johnston, B. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub4 · Cited by 550 · see citing works
Dai, Z., Coker, O. O., Nakatsu, G., Wu, W. K. K., Zhao, L., Chen, Z., Chan, F. K. L., Kristiansen, K., Sung, J. J. Y., Wong, S. H., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0451-2 · Cited by 545 · see citing works
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490 · see citing works
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Guo, Q., Goldenberg, J. Z., Humphrey, C., El Dib, R., & Johnston, B. C. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub5 · Cited by 275 · see citing works
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Jäger, R., Purpura, M., Stone, J., Turner, S., Anzalone, A., Eimerbrink, M., Pane, M., Amoruso, A., Rowlands, D., & Oliver, J. (2016) · Nutrients · doi:10.3390/nu8100642 · Cited by 89 · see citing works
Segui-Perez, C., Huang, L. Z. X., Paganelli, F. L., Lievens, E., & Strijbis, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-92125-2 · Cited by 45 · see citing works
Kligler, B., Hanaway, P., & Cohrssen, A. (2007) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2007.10.002 · Cited by 41 · see citing works
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Marchand, V. (2012) · Paediatrics & Child Health · doi:10.1093/pch/17.10.575 · Cited by 42 · see citing works
McFarland, L. V. (2013) · World Journal of Meta-Analysis · doi:10.13105/wjma.v1.i3.102 · Cited by 33 · see citing works
- Authors
- Corrêa, N. B. O., Péret Filho, L. A., Penna, F. J., Lima, F. M. L. S., & Nicoli, J. R.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal de Goiás (BR)
- Corresponding author
- Corrêa, Naflesia B. O
- Penna, Francisco J
- ORCID
- Nicoli, Jacques R
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2005-05
- Volume
- 39
- Issue
- 5
- Pages
- 385-389
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2030409548
- Cited by
- 208
- References
- 31
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 12 · 2020: 9 · 2019: 15 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 14 · 2012: 16
- FWCI
- 20.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- antibiotic-associated diarrhea, probiotics, Bifidobacterium animalis subsp. lactis, Streptococcus thermophilus, infants, diarrhea prevention, antibiotic therapy
- MeSH terms
- Administration, Oral, Anti-Bacterial Agents, Bifidobacterium, Diarrhea, Double-Blind Method, Female, Follow-Up Studies, Humans, Infant, Infections, Male, Treatment Outcome, Probiotics, Streptococcus thermophilus
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