Probiotics in Children

Kligler, Benjamin; Hanaway, Patrick; Cohrssen, Andreas

doi:10.1016/j.pcl.2007.10.002

Cited by 41Probiotics and Fermented FoodsInfant Nutrition and HealthGastrointestinal motility and disorders

Probiotics in Children

Kligler, Benjamin, Hanaway, Patrick, Cohrssen, Andreas·2007·Pediatric Clinics of North America

DOI 10.1016/j.pcl.2007.10.002

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Abstract

The gastrointestinal flora plays a complex and important role in the development of healthy immunologic and digestive function in children. Probiotics are safe in healthy children and effective in reducing the risk of antibiotic-associated diarrhea and the duration of acute infectious diarrhea. Probiotics may also be effective in preventing community-acquired diarrheal infections, in reducing the risk of necrotizing enterocolitis in premature infants, and in the prevention and treatment of atopic dermatitis. The exact strain or combination of strains most effective for common clinical indications has yet to be determined, but the exact strain used seems less important than whether an adequate dose is used (typically 5 to 10 billion CFUs per day or higher). Clinicians should familiarize themselves with the products available because there is a wide range in their quality.

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Key strains like Lactobacillus rhamnosus GG, Bifidobacterium, Bacillus spp., and Saccharomyces cerevisiae boulardii are given at 5-20 billion CFUs/d based on age.
“Key strains like Lactobacillus rhamnosus GG, Bifidobacterium, Bacillus spp., and Saccharomyces cerevisiae boulardii are given at 5–20 billion CFUs/d based on age.4,5”
From Safety and efficacy concerns in Indian probiotics: Insights from whole-genome sequencing and in vitro assessment (2026) · cites this paper as [5]

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Authors: Kligler, B., Hanaway, P., & Cohrssen, A.
Affiliations: Albert Einstein College of Medicine (US)
Mount Sinai Beth Israel (US)
Corresponding author: Kligler, Benjamin
ORCID: Kligler, Benjamin
Hanaway, Patrick
Venue: Pediatric Clinics of North America
Publisher: Elsevier BV
Published: 2007-12
Volume: 54
Issue: 6
Pages: 949-967
ISSN: 0031-3955 (ISSN-L)
DOI: 10.1016/j.pcl.2007.10.002
OpenAlex: W2026233364
Cited by: 41
References: 79
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 6 · 2012: 6
FWCI: 0.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pediatric Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: probiotics, children, gut microbiota, antibiotic-associated diarrhea, infectious diarrhea, community-acquired diarrhea, necrotizing enterocolitis, preterm infants, atopic dermatitis, probiotic dosage, probiotic safety
MeSH terms: Complementary Therapies, Child, Colic, Dermatitis, Atopic, Diarrhea, Humans, Intestines, Probiotics

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