The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis
Open accessAbstract
Glucose had long been thought to fuel oxidative metabolism in active neurons until the recently proposed astrocyte-neuron lactate shuttle hypothesis (ANLSH) challenged this view. According to the ANLSH, activity-induced uptake of glucose takes place predominantly in astrocytes, which metabolize glucose anaerobically. Lactate produced from anaerobic glycolysis in astrocytes is then released from astrocytes and provides the primary metabolic fuel for neurons. The conventional hypothesis asserts that glucose is the primary substrate for both neurons and astrocytes during neural activity and that lactate produced during activity is removed mainly after neural activity. The conventional hypothesis does not assign any particular fraction of glucose metabolism to the aerobic or anaerobic pathways. In this review, the authors discuss the theoretical background and critically review the experimental evidence regarding these two hypotheses. The authors conclude that the experimental evidence for the ANLSH is weak, and that existing evidence and theoretical considerations support the conventional hypothesis.
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Cites
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Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
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Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
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Lactate release from cultured astrocytes and neurons: A comparison
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Do active cerebral neurons really use lactate rather than glucose?
Chih, C.-P., Lipton, P., & Roberts, E. L. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01920-2 · Cited by 252 · cited 6×
“Several studies have shown that 4-CIN by itself compromises normal oxidative metabolism and blocks neural activity (e.g., Amos and Richards, 1996; Chih et al., 2001a; McKenna et al., 2001).”
BackgroundResultInfluentialBergersen, L., Wærhaug, O., Helm, J., Thomas, M., Laake, P., Davies, A. J., Wilson, M. C., Halestrap, A. P., & Ottersen, O. P. (2001) · Experimental Brain Research · doi:10.1007/s002210000600 · Cited by 155 · cited 9×
“Distribution of monocarboxylate transporters in neurons and astrocytes The distribution of monocarboxylate transporters in the brain is heterogeneous because neurons have mainly monocarboxylate transporter 2 (MCT2), whereas astrocytes have MCT1, MCT2, and MCT4 (Bergersen et al., 2001; Gerhart et al., 1998; Pellerin et…”
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Cited by
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
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Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Raichle, M. E. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.01.008 · Cited by 1,111
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Metadata
- Authors
- Chih, C.-P., & Roberts, E. L.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2003-11
- Volume
- 23
- Issue
- 11
- Pages
- 1263-1281
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2092969356
- Cited by
- 325
- References
- 11
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chih, C.-P., & Roberts, E. L. (2003). Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1097/01.wcb.0000081369.51727.6f
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