Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity
Open accessAbstract
Background: Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying the loss of volitional motor responses. Methods: The authors recorded local field potentials from sensorimotor cortices in patients with Parkinson disease (N = 12) and essential tremor (N = 7) undergoing deep brain stimulation surgery, before and after propofol-induced loss of consciousness. Local spectral power and interregional connectivity (coherence and imaginary coherence) were evaluated separately across conditions for the two populations. Results: Propofol anesthesia caused power increases for frequencies between 2 and 100 Hz across the sensorimotor cortices and a shift of the dominant spectral peak in α and β frequencies toward lower frequencies (median ± SD peak frequency: 24.5 ± 2.6 Hz to 12.8 ± 2.3 Hz in Parkinson disease; 13.8 ± 2.1 Hz to 12.1 ± 1.0 Hz in essential tremor). Despite local increases in power, sensorimotor cortical coherence was suppressed with propofol in both cohorts, specifically in β frequencies (18 to 29 Hz) for Parkinson disease and α and β (10 to 48 Hz) in essential tremor. Conclusions: The decrease in functional connectivity between sensory and motor cortices, despite an increase in local spectral power, suggests that propofol causes a functional disconnection of cortices with increases in autonomous activity within cortical regions. This pattern occurs across diseases evaluated, suggesting that these may be generalizable effects of propofol in patients with movement disorders and beyond. Sensorimotor network disruption may underlie anesthetic-induced loss of volitional control.
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Electrocorticography during propofol and ketamine anesthesia in human and non-human primates reveals disrupted functional connectivity across S1 and M1 cortex, as well as altered beta oscillations typically associated with feedback processing.
“Electrocorticography during propofol (Malekmohammadi et al., 2018) and ketamine (Schroeder et al., 2016) anesthesia in human and non-human primates, respectively, reveals disrupted functional connectivity across the S1 and M1 cortex, as well as altered beta oscillations, which are typically associated with feedback processing (Bastos et al., 2015).”
From Conscious Processing and the Global Neuronal Workspace Hypothesis (2020) · cites this paper as Malekmohammadi et al., 2018
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Conscious Processing and the Global Neuronal Workspace Hypothesis
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Leveraging Nonhuman Primate Multisensory Neurons and Circuits in Assessing Consciousness Theory
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- Authors
- Malekmohammadi, M., AuYong, N., Price, C. M., Tsolaki, E., Hudson, A. E., & Pouratian, N.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Malekmohammadi, Mahsa
- Venue
- Anesthesiology
- Published
- 2018-02
- Volume
- 128
- Issue
- 2
- Pages
- 305-316
- ISSN
- 0003-3022 (ISSN-L)
- PMC
- PMC5771969
- OpenAlex
- W2765882424
- Cited by
- 23
- References
- 64
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 5 · 2018: 4
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Parkinson Disease Association
- National Institute of General Medical Sciences (K08GM121961)
- National Institute of Neurological Disorders and Stroke (R01NS097782)
- National Institute of Biomedical Imaging and Bioengineering (K23EB014326)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- propofol anesthesia, sensorimotor cortex, functional connectivity, alpha oscillations, beta oscillations, local field potentials, Parkinson's disease, essential tremor, movement disorders, loss of consciousness, deep brain stimulation, spectral power, coherence, imaginary coherence
- MeSH terms
- Aged, Electroencephalography, Female, Humans, Male, Neural Pathways, Parkinson Disease, Propofol, Anesthetics, Intravenous, Essential Tremor, Deep Brain Stimulation, Sensorimotor Cortex
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