Cited by 85Neurotransmitter Receptor Influence on BehaviorEating Disorders and BehaviorsRegulation of Appetite and Obesity

Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats

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Grimm, Jeffery W., Osincup, Daniel, Wells, Barbara, Manaois, Meghan, Fyall, Amber, Buse, Carl, Harkness, John H.·2008·Behavioural Pharmacology

Abstract

This study examined the effect of environmental enrichment on sucrose seeking in rats made abstinent from sucrose for 1 month, as measured by response for a tone+light cue previously associated with 10% sucrose self-administration. Rats were either enriched throughout the study (experiment 1) or only after sucrose self-administration training (experiment 2). Enrichment consisted of either housing the rats in pairs or grouping four rats (ENR4) in a large environment, both with novel objects. Controls (CON) were singly housed without novel objects. In experiment 1, ENR4 rats responded less to the sucrose-paired cue versus CON rats, but this difference was not statistically significant. In contrast, the decrease in response of ENR4 rats versus CON rats in experiment 2 was dramatic and significant. These findings, along with findings from other laboratories, support a hypothesis that the enrichment may provide individuals with a greater ability to discriminate the availability of reward. This may impart a decreased vulnerability to relapse behavior. Therefore, these results are relevant to both eating disorder and drug addiction - disorders characterized by relapse.

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  • Abstinence from sucrose can cause craving and withdrawal symptoms, eventually leading to relapse behavior.

    “As with drug ([71](#B71), [96](#B96), [156](#B156)) and alcohol ([18](#B18), [185](#B185)) addiction, abstinence from sucrose can cause craving and withdrawal symptoms ([5](#B5)), eventually leading to relapse behavior ([72](#B72), [73](#B73)).”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [73]

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Authors
Grimm, J. W., Osincup, D., Wells, B., Manaois, M., Fyall, A., Buse, C., & Harkness, J. H.
Affiliations
Western Washington University (US)
Corresponding author
Grimm, Jeffery W.
Venue
Behavioural Pharmacology
Published
2008-12
Volume
19
Issue
8
Pages
777-785
ISSN
0955-8810 (ISSN-L)
OpenAlex
W2055149660
Cited by
85
References
49
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 12 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 1 · 2012: 2
FWCI
2.31
Type
journal article
Language
en
Open access
Locations
  • Behavioural Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R15DA016285, R15 DA016285-01-S1)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
environmental enrichment, sucrose seeking, cue-induced reinstatement, sucrose self-administration, relapse, social housing, novel objects, food addiction, eating disorders, drug addiction
MeSH terms
Analysis of Variance, Animals, Association Learning, Body Weight, Cocaine, Cues, Environment, Exploratory Behavior, Extinction, Psychological, Male, Motor Activity, Reinforcement, Psychology, Self Administration, Sucrose, Sweetening Agents, Dopamine Uptake Inhibitors, Rats, Long-Evans, Rats

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