Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats
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This study examined the effect of environmental enrichment on sucrose seeking in rats made abstinent from sucrose for 1 month, as measured by response for a tone+light cue previously associated with 10% sucrose self-administration. Rats were either enriched throughout the study (experiment 1) or only after sucrose self-administration training (experiment 2). Enrichment consisted of either housing the rats in pairs or grouping four rats (ENR4) in a large environment, both with novel objects. Controls (CON) were singly housed without novel objects. In experiment 1, ENR4 rats responded less to the sucrose-paired cue versus CON rats, but this difference was not statistically significant. In contrast, the decrease in response of ENR4 rats versus CON rats in experiment 2 was dramatic and significant. These findings, along with findings from other laboratories, support a hypothesis that the enrichment may provide individuals with a greater ability to discriminate the availability of reward. This may impart a decreased vulnerability to relapse behavior. Therefore, these results are relevant to both eating disorder and drug addiction - disorders characterized by relapse.
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Abstinence from sucrose can cause craving and withdrawal symptoms, eventually leading to relapse behavior.
“As with drug ([71](#B71), [96](#B96), [156](#B156)) and alcohol ([18](#B18), [185](#B185)) addiction, abstinence from sucrose can cause craving and withdrawal symptoms ([5](#B5)), eventually leading to relapse behavior ([72](#B72), [73](#B73)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [73]
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- Authors
- Grimm, J. W., Osincup, D., Wells, B., Manaois, M., Fyall, A., Buse, C., & Harkness, J. H.
- Affiliations
- Western Washington University (US)
- Corresponding author
- Grimm, Jeffery W.
- ORCID
- Harkness, John H.
- Venue
- Behavioural Pharmacology
- Published
- 2008-12
- Volume
- 19
- Issue
- 8
- Pages
- 777-785
- ISSN
- 0955-8810 (ISSN-L)
- PMC
- PMC2880547
- OpenAlex
- W2055149660
- Cited by
- 85
- References
- 49
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 12 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 1 · 2012: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R15DA016285, R15 DA016285-01-S1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- environmental enrichment, sucrose seeking, cue-induced reinstatement, sucrose self-administration, relapse, social housing, novel objects, food addiction, eating disorders, drug addiction
- MeSH terms
- Analysis of Variance, Animals, Association Learning, Body Weight, Cocaine, Cues, Environment, Exploratory Behavior, Extinction, Psychological, Male, Motor Activity, Reinforcement, Psychology, Self Administration, Sucrose, Sweetening Agents, Dopamine Uptake Inhibitors, Rats, Long-Evans, Rats
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