Cited by 634Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

The Obstetric Origins of Health for a Lifetime

BARKER, DAVID J.P., THORNBURG, KENT L.·2013·Clinical Obstetrics & Gynecology

Abstract

There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.

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Crossref · 10.1097/grf.0b013e31829cb9ca

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  • Perturbation of gene expression or cell proliferation and differentiation during vulnerable periods by nutritional and other environmental influences can alter the structure and functional capacity of major organ systems for life, a process known as developmental programming.

    “Perturbation of gene expression or cell proliferation and differentiation during vulnerable periods by nutritional and other environmental influences can alter the structure and functional capacity of major organ systems for life, a process known as developmental programming.”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [37]

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Authors
BARKER, D. J. P., & THORNBURG, K. L.
Affiliations
  • MRC Lifecourse Epidemiology Unit (GB)
  • Oregon Health & Science University (US)
Corresponding author
BARKER, DAVID J.P.
Venue
Clinical Obstetrics & Gynecology
Published
2013-09
Volume
56
Issue
3
Pages
511-519
ISSN
0009-9201 (ISSN-L)
OpenAlex
W2070920134
Cited by
634
References
49
Citations by year
2026: 13 · 2025: 10 · 2024: 14 · 2023: 15 · 2022: 20 · 2021: 25 · 2020: 37 · 2019: 389 · 2018: 25 · 2017: 30 · 2016: 26 · 2015: 21 · 2014: 7 · 2013: 1
FWCI
17.08
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Obstetrics & Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
developmental origins of health and disease, fetal programming, fetal nutrition, epigenetic gene expression, immune system, antioxidant defense, inflammation, stem cells, chronic disease
MeSH terms
Birth Weight, Coronary Disease, Diabetes Mellitus, Type 2, Female, Humans, Placental Insufficiency, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development

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