The Obstetric Origins of Health for a Lifetime
Abstract
There is a new "developmental" model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal variations in fetoplacental development. These variations are thought to lead to variations in the supply of nutrients to the baby that permanently alter gene expression, a process known as "programming." According to the developmental model variations in the processes of development program the function of a few key systems that are linked to disease, including the immune system, antioxidant defenses, inflammatory responses, and the number and quality of stem cells.
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Perturbation of gene expression or cell proliferation and differentiation during vulnerable periods by nutritional and other environmental influences can alter the structure and functional capacity of major organ systems for life, a process known as developmental programming.
“Perturbation of gene expression or cell proliferation and differentiation during vulnerable periods by nutritional and other environmental influences can alter the structure and functional capacity of major organ systems for life, a process known as developmental programming.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [37]
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- Authors
- BARKER, D. J. P., & THORNBURG, K. L.
- Affiliations
- MRC Lifecourse Epidemiology Unit (GB)
- Oregon Health & Science University (US)
- Corresponding author
- BARKER, DAVID J.P.
- ORCID
- THORNBURG, KENT L.
- Venue
- Clinical Obstetrics & Gynecology
- Published
- 2013-09
- Volume
- 56
- Issue
- 3
- Pages
- 511-519
- ISSN
- 0009-9201 (ISSN-L)
- OpenAlex
- W2070920134
- Cited by
- 634
- References
- 49
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 14 · 2023: 15 · 2022: 20 · 2021: 25 · 2020: 37 · 2019: 389 · 2018: 25 · 2017: 30 · 2016: 26 · 2015: 21 · 2014: 7 · 2013: 1
- FWCI
- 17.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Obstetrics & Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- developmental origins of health and disease, fetal programming, fetal nutrition, epigenetic gene expression, immune system, antioxidant defense, inflammation, stem cells, chronic disease
- MeSH terms
- Birth Weight, Coronary Disease, Diabetes Mellitus, Type 2, Female, Humans, Placental Insufficiency, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development
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