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Cited by 254

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial

Lozano, Lourdes, Tovar, José Luis, Sampol, Gabriel, Romero, Odile, Jurado, María José, Segarra, Alfons, Espinel, Eugènia, Ríos, José, Untoria, María Dolores, Lloberes, Patrícia·2010·Journal of Hypertension
DOI 10.1097/hjh.0b013e32833b9c63
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Abstract

OBJECTIVES: This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood pressure (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). METHODS: We evaluated 96 patients with resistant hypertension, defined as clinic BP at least 140/90 mmHg despite treatment with at least three drugs at adequate doses, including a diuretic. Patients underwent a polysomnography and a 24-h ambulatory BP monitoring (ABPM). They were classified as consulting room or ABPM-confirmed resistant hypertension, according to 24-h BP lower or higher than 125/80 mmHg. Patients with an apnea-hypopnea index at least 15 events/h (n = 75) were randomized to receive either CPAP added to conventional treatment (n = 38) or conventional medical treatment alone (n = 37). ABPM was repeated at 3 months. The main outcome was the change in systolic and diastolic BP. RESULTS: Sixty-four patients completed the follow-up. Patients with ABPM-confirmed resistant hypertension treated with CPAP (n = 20), unlike those treated with conventional treatment (n = 21), showed a decrease in 24-h diastolic BP (-4.9 ± 6.4 vs. 0.1 ± 7.3 mmHg, P = 0.027). Patients who used CPAP > 5.8 h showed a greater reduction in daytime diastolic BP {-6.12 mmHg [confidence interval (CI) -1.45; -10.82], P = 0.004}, 24-h diastolic BP (-6.98 mmHg [CI -1.86; -12.1], P = 0.009) and 24-h systolic BP (-9.71 mmHg [CI -0.20; -19.22], P = 0.046). The number of patients with a dipping pattern significantly increased in the CPAP group (51.7% vs. 24.1%, P = 0.008). CONCLUSION: In patients with resistant hypertension and OSA, CPAP treatment for 3 months achieves reductions in 24-h BP. This effect is seen in patients with ABPM-confirmed resistant hypertension who use CPAP more than 5.8 h.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 26

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Metadata

Authors
Lozano, L., Tovar, J. L., Sampol, G., Romero, O., Jurado, M. J., Segarra, A., Espinel, E., Ríos, J., Untoria, M. D., & Lloberes, P.
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-10
Volume
28
Issue
10
Pages
2161-2168
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/hjh.0b013e32833b9c63
OpenAlex
W1973005133
Cited by
254
References
9
FWCI
15.03
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial. https://app.cochat.ai/papers/10.1097/hjh.0b013e32833b9c63
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Lozano, L., Tovar, J. L., Sampol, G., Romero, O., Jurado, M. J., Segarra, A., Espinel, E., Ríos, J., Untoria, M. D., & Lloberes, P. (2010). Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial. Journal of Hypertension. https://doi.org/10.1097/hjh.0b013e32833b9c63

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