The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis
Open accessAbstract
Objective: Following traumatic brain injury (TBI), depressive symptoms are common and may influence recovery. We performed a meta-analysis to estimate the benefit of antidepressants following TBI and compare the estimated effects between antidepressants and placebo. Participants: Multiple databases were searched to find prospective pharmacological treatment studies of major depressive disorder (MDD) in adults following TBI. Main Measures: Effect sizes for antidepressant medications in patients with TBI were calculated for within-subjects designs that examined change from baseline after receiving medical treatment and treatment/placebo designs that examined the differences between the antidepressants and placebo groups. Design: A random-effects model was used for both analyses. Results: Of 1028 titles screened, 11 were included. Pooled estimates showed nonsignificant difference in reduction of depression scores between medications and placebo (standardized mean difference of 5 trials = −0.3; 95% CI, −0.6 to 0.0; I 2 = 17%), and a significant reduction in depression scores for individuals after pharmacotherapy (mean change = −11.2; 95% CI, −14.7 to −7.6 on the Hamilton Depression Scale; I 2 = 87%). Conclusions: This meta-analysis found no significant benefit of antidepressant over placebo in the treatment of MDD following TBI. Pooled estimates showed a high degree of bias and heterogeneity. Prospective studies on the impact of antidepressants in well-defined cohorts of TBI patients are warranted.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Antidepressants have not been shown to be more beneficial than placebo when treating depression following traumatic brain injury.
“Furthermore, antidepressants have not been shown to be more beneficial than placebo when treating depression following TBI [9].”
Recent meta-analyses have shown either borderline or no significant benefits of antidepressants over placebo in the treatment of post-TBI MDD.
“recent meta-analyses have shown either borderline11 or no significant10 benefits of antidepressants over placebo in the treatment of post-TBI MDD.”
The reliability of previous meta-analyses was affected by a high degree of bias and heterogeneity, or by a limited number of included studies.
“the reliability of the results of previous meta-analyses was affected by a high degree of bias and heterogeneity,10 or by a limited number of included studies.11”
Previous pair-wise meta-analyses have investigated the efficacy of antidepressants for post-TBI depression with mixed results.
“several pair-wise meta-analyses have investigated the efficacy of antidepressants, with mixed results.10–12”
There is no consensus on standard therapeutic guidelines for post-TBI depression.
“despite the prevalence and severity of post-TBI depression, there is no consensus on standard therapeutic guidelines.10”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042 · see citing works
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,759 · see citing works
Taylor, C. A., Bell, J. M., Breiding, M. J., & Xu, L. (2017) · MMWR Surveillance Summaries · doi:10.15585/mmwr.ss6609a1 · Cited by 2,331 · see citing works
Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis
Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010) · JAMA · doi:10.1001/jama.2009.1943 · Cited by 2,009 · see citing works
New insights into BDNF function in depression and anxiety
Martinowich, K., Manji, H., & Lu, B. (2007) · Nature Neuroscience · doi:10.1038/nn1971 · Cited by 1,221 · see citing works
Major Depression Following Traumatic Brain Injury
Jorge, R. E., Robinson, R. G., Moser, D., Tateno, A., Crespo-Facorro, B., & Arndt, S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.42 · Cited by 737 · see citing works
Prevalence of Chronic Pain After Traumatic Brain Injury: A Systematic Review
Nampiaparampil, D. E. (2008) · JAMA · doi:10.1001/jama.300.6.711 · Cited by 673 · see citing works
Zaloshnja, E., Miller, T. R., Langlois, J. A., & Selassie, A. W. (2008) · Journal of Head Trauma Rehabilitation · doi:10.1097/01.htr.0000341435.52004.ac · Cited by 609 · see citing works
The five year outcome of severe blunt head injury: a relative's view.
Brooks, N. H., Campsie, L. M., Symington, C., Beattie, A., & McKinlay, W. W. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.7.764 · Cited by 579 · see citing works
Selassie, A. W., Zaloshnja, E., Langlois, J. A., Miller, T. R., Jones, P. R., & Steiner, C. (2008) · Journal of Head Trauma Rehabilitation · doi:10.1097/01.htr.0000314531.30401.39 · Cited by 556 · see citing works
Axis I Psychopathology in Individuals with Traumatic Brain Injury
Hibbard, M. R., Uysal, S., Kepler, K., Bogdany, J., & Silver, J. (1998) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-199808000-00003 · Cited by 491 · see citing works
Kreutzer, J. S., Seel, R. T., & Gourley, E. (2001) · Brain Injury · doi:10.1080/02699050010009108 · Cited by 417 · see citing works
Head Injury in Early Adulthood and the Lifetime Risk of Depression
Holsinger, T., Steffens, D. C., Phillips, C., Helms, M. J., Havlik, R. J., Breitner, J. C. S., Guralnik, J. M., & Plassman, B. L. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.1.17 · Cited by 267 · see citing works
Current Status of Co-Occurring Mood and Substance Use Disorders: A New Therapeutic Target
Pettinati, H. M., O’Brien, C. P., & Dundon, W. D. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12010112 · Cited by 254 · see citing works
Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication
Chen, C.-H., Suckling, J., Ooi, C., Fu, C. H. Y., Williams, S. C. R., Walsh, N. D., Mitterschiffthaler, M. T., Pich, E. M., & Bullmore, E. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301593 · Cited by 224 · see citing works
Depression following traumatic brain injury: a 1 year longitudinal study
Jorge, R. E., Robinson, R. G., Arndt, S. V., STARKSTEIN, S. E., Forrester, A. W., & Geisler, F. H. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90047-n · Cited by 221 · see citing works
Sertraline in the Treatment of Major Depression Following Mild Traumatic Brain Injury
Fann, J. R., Uomoto, J. M., & Katon, W. J. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.2.226 · Cited by 207 · see citing works
Lee, H., Kim, S., Kim, J., Shin, I., Yang, S., & Yoon, J. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.668 · Cited by 205 · see citing works
Kurowski, B. G., Hugentobler, J. A., Quatman‐Yates, C. C., Taylor, J. L., Gubanich, P., Altaye, M., & Wade, S. L. (2016) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000238 · Cited by 184 · see citing works
Self-citationPonsford, J., Lee, N. K., Wong, D., McKay, A., Haines, K., Alway, Y., Downing, M., Furtado, C., & O'Donnell, M. L. (2016) · Psychological Medicine · doi:10.1017/s0033291715002640 · Cited by 173 · see citing works
Haagsma, J. A., Scholten, A. C., Andriessen, T. M. J. C., Vos, P. E., van Beeck, E. F., & Polinder, S. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3283 · Cited by 163 · see citing works
Kaplan, G. B., Vasterling, J. J., & Vedak, P. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833d8bc9 · Cited by 163 · see citing works
Ashman, T. A., Cantor, J. B., Gordon, W. A., Spielman, L., Flanagan, S., Ginsberg, A., Engmann, C., Egan, M., Ambrose, F., & Greenwald, B. (2009) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.11.005 · Cited by 149 · see citing works
Fann, J. R., Bombardier, C. H., Vannoy, S., Dyer, J., Ludman, E., Dikmen, S., Marshall, K., Barber, J., & Temkin, N. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3423 · Cited by 147 · see citing works
Osborn, A. J., Mathias, J. L., & Fairweather‐Schmidt, A. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.007 · Cited by 140 · see citing works
Luby, J. L., Barch, D., Whalen, D., Tillman, R., & Belden, A. (2017) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2017.3009 · Cited by 134 · see citing works
Lydiard, R. B., Stahl, S. M., Hertzman, M., & Harrison, W. M. (1997) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v58n1104 · Cited by 126 · see citing works
Bédard, M., Felteau, M., Marshall, S., Cullen, N. K., Gibbons, C., Dubois, S. J., Maxwell, H., Mazmanian, D. S., Weaver, B., Rees, L. M., et al. (2013) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3182a615a0 · Cited by 115 · see citing works
Pagulayan, K. F., Hoffman, J. M., Temkin, N. R., Machamer, J., & DIKMEN, S. S. (2008) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2008.03.019 · Cited by 111 · see citing works
Hippocampal Volume and Mood Disorders After Traumatic Brain Injury
Jorge, R. E., Ación, L., STARKSTEIN, S. E., & Magnotta, V. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.024 · Cited by 107 · see citing works
Clinical Considerations for the Diagnosis of Major Depression After Moderate to Severe TBI
Seel, R. T., Macciocchi, S. N., & Kreutzer, J. S. (2010) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181ce3966 · Cited by 104 · see citing works
Juengst, S. B., Kumar, R. G., Failla, M. D., Goyal, A., & Wagner, A. K. (2014) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000031 · Cited by 96 · see citing works
Sepehry, A. A., Lee, P. E., Hsiung, G. Y. R., Beattie, B. L., & Jacova, C. (2012) · Drugs & Aging · doi:10.1007/s40266-012-0012-5 · Cited by 94 · see citing works
A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression.
Bremner, J. D. (1995) · PubMed · Cited by 92 · see citing works
Fluoxetine's Effects on Cognitive Performance in Patients with Traumatic Brain Injury
Horsfield, S. A., Rosse, R. B., Tomasino, V., Schwartz, B. L., Mastropaolo, J. P., & Deutsch, S. I. (2002) · The International Journal of Psychiatry in Medicine · doi:10.2190/kq48-xt0l-2h14-5umv · Cited by 87 · see citing works
Chronic pain, TBI, and PTSD in military veterans: A link to suicidal ideation and violent impulses?
Blakey, S. M., Wagner, H. R., Naylor, J., Brancu, M., Lane, I., Sallee, M., Kimbrel, N. A., & Elbogen, E. B. (2018) · The Journal of Pain · doi:10.1016/j.jpain.2018.02.012 · Cited by 86 · see citing works
Fann, J. R., Bombardier, C. H., Temkin, N., Esselman, P., Warms, C., Barber, J., & Dikmen, S. (2017) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000322 · Cited by 82 · see citing works
Contribution of spontaneous improvement to placebo response in depression: A meta-analytic review
Rutherford, B. R., Mori, S., Sneed, J. R., Pimontel, M. A., & Roose, S. P. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.02.008 · Cited by 79 · see citing works
Treatment resistance of depression after head injury: a preliminary study of amitriptyline response
Dinan, T. G., & Mobayed, M. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb01472.x · Cited by 74 · see citing works
Saran, A. (1985) · PubMed · Cited by 70 · see citing works
An open-label study of citalopram for major depression following traumatic brain injury
Mj, R., Chan, F., Lanctôt, K. L., Herrmann, N., McCullagh, S., & Feinstein, A. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107083845 · Cited by 69 · see citing works
Entsuah, R., Shaffer, M., & Zhang, J. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00024-9 · Cited by 61 · see citing works
Failla, M. D., Juengst, S. B., Arenth, P. M., & Wagner, A. K. (2015) · Neurorehabilitation and neural repair · doi:10.1177/1545968315600525 · Cited by 59 · see citing works
Brain morphometry changes and depressive symptoms after traumatic brain injury
Hudak, A. M., Warner, M. A., de la Plata, C. M., Moore, C. B., Harper, C. R., & Diaz-Arrastia, R. R. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.10.003 · Cited by 57 · see citing works
New approaches in the pharmacotherapy of posttraumatic stress disorder.
Silver, J., Sandberg, D. P., & Hales, R. E. (1990) · PubMed · Cited by 56 · see citing works
Han, K., Chapman, S. B., & Krawczyk, D. C. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00231 · Cited by 51 · see citing works
Homovanillic Acid and 5-Hydroxyindoleacetic Acid Cerebrospinal Fluid Levels
Vecht, C. J. (1975) · Archives of Neurology · doi:10.1001/archneur.1975.00490540036004 · Cited by 49 · see citing works
Dyer, J. R., Williams, R. T., Bombardier, C. H., Vannoy, S. D., & Fann, J. R. (2015) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000177 · Cited by 47 · see citing works
Venlafaxine Extended-Release for Depression Following Spinal Cord Injury
Fann, J. R., Bombardier, C. H., Richards, J. S., Wilson, C. S., Heinemann, A. W., Warren, A. M., Brooks, L., McCullumsmith, C. B., Temkin, N. R., Warms, C. A., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2482 · Cited by 44 · see citing works
Self-citationJuengst, S. B., Wagner, A. K., Ritter, A. C., Szaflarski, J. P., Walker, W. C., ZAFONTE, R. D., Brown, A. W., Hammond, F. M., Pugh, M. J., Shea, T., et al. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.06.001 · Cited by 42 · see citing works
Variants of SLC6A4 in depression risk following severe TBI
Failla, M. D., Burkhardt, J. N., Miller, M. A., Scanlon, J. M., Conley, Y. P., Ferrell, R. E., & Wagner, A. K. (2013) · Brain Injury · doi:10.3109/02699052.2013.775481 · Cited by 40 · see citing works
Pharmacotherapy for Depression Posttraumatic Brain Injury: A Meta-analysis
Salter, K. L., McClure, J. A., Foley, N. C., Sequeira, K., & Teasell, R. W. (2015) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000193 · Cited by 37 · see citing works
The (Eigen)value of diffusion tensor imaging to investigate depression after traumatic brain injury
Maller, J. J., Thomson, R. H., Pannek, K., Rose, S., Bailey, N. W., Lewis, P., & Fitzgerald, P. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.22171 · Cited by 34 · see citing works
Moclobemide in the treatment of major depressive disorder (DSM-3) following traumatic brain injury
Newburn, G. (1999) · Brain Injury · doi:10.1080/026990599121368 · Cited by 30 · see citing works
Role of sertraline in posttraumatic brain injury depression and quality-of-life in TBI
Ansari, A., Jain, A., Sharma, A., Mittal, R., & Gupta, I. (2014) · Asian Journal of Neurosurgery · doi:10.4103/1793-5482.146597 · Cited by 27 · see citing works
Diffusion Tensor Imaging Atlas-Based Analyses in Major Depression After Mild Traumatic Brain Injury
Rao, V., Mielke, M. M., Xu, X., Smith, G. S., McCann, U. D., Bergey, A., Doshi, V., Pham, D. L., Yousem, D. M., & Mori, S. (2012) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.11080188 · Cited by 27 · see citing works
Volumetrics relate to the development of depression after traumatic brain injury
Maller, J. J., Thomson, R. H., Pannek, K., Bailey, N. W., Lewis, P., & Fitzgerald, P. B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.047 · Cited by 24 · see citing works
Bailey, N. W., Segrave, R. A., Hoy, K. E., Maller, J. J., & Fitzgerald, P. B. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.03.008 · Cited by 23 · see citing works
Márquez-Romero, J. M., Araúz, A., Ruíz‐Sandoval, J. L., de la Cruz-Estrada, E., Franco, M. R. H., Aguayo-Leytte, G., Ruíz-Franco, A., & Silos, H. (2013) · Trials · doi:10.1186/1745-6215-14-77 · Cited by 23 · see citing works
The relationship between mood disorders and MRI findings following traumatic brain injury
Schönberger, M., Ponsford, J. L., Reutens, D. C., Beare, R. J., Clarke, D. M., & O’Sullivan, R. (2011) · Brain Injury · doi:10.3109/02699052.2011.565013 · Cited by 21 · see citing works
New approaches to increase statistical power in TBI trials: insights from the IMPACT study.
Maas, A., & Lingsma, H. F. (2008) · Acta neurochirurgica. Supplement · doi:10.1007/978-3-211-78205-7_20 · Cited by 16 · see citing works
Current Status of Co-Occurring Mood and Substance Use Disorders: A New Therapeutic Target
Pettinati, H. M., O’Brien, C. P., & Dundon, W. D. (2015) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.130310 · Cited by 15 · see citing works
Flagged first, then by citations
2 of the 65 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [14]Silver JM, Hales RE, Yudofsky SC. Psychopharmacology of depression in neurologic disorders. J Clin Psychiatry. 1990; 51 (suppl): 33– 39. 2404002
- [22]Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Vol 4. Chichester, UK: John Wiley & Sons; 2011.
- [25]Viechtbauer W. Conducting meta-analyses in R with the metaphor Package. J Stat Software. 2010; 36(3): 1– 48. http://www.jstatsoft.org/v36/i03. fAccessed November 28, 2017.
Cited by
Sorted by citations
Impact of Traumatic Brain Injury on Neurogenesis
Ngwenya, L. B., & Danzer, S. C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01014 · Cited by 71 · see citing works
Self-citationKhatri, N., Bommaraju, S., Kumar, S., Kaundal, R. K., Sharma, S., & Datusalia, A. K. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210215123914 · Cited by 63 · see citing works
Antidepressants for depression after concussion and traumatic brain injury are still best practice
Silverberg, N. D., & Panenka, W. J. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2076-9 · Cited by 57 · see citing works
Broadening horizons: ferroptosis as a new target for traumatic brain injury
Wei, Z., Yu, H., Zhao, H., Wei, M., Xing, H., Pei, J., Yang, Y., & Ren, K. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad051 · Cited by 44 · see citing works
Management of Psychological Complications Following Mild Traumatic Brain Injury
Silverberg, N. D., & Mikolić, A. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01251-9 · Cited by 39 · see citing works
Gut Microbiome Modulation of Glutamate Dynamics: Implications for Brain Health and Neurotoxicity
Gruenbaum, B. F., Merchant, K. S., Zlotnik, A. A., & Boyko, M. (2024) · Nutrients · doi:10.3390/nu16244405 · Cited by 33 · see citing works
Conroy, S. K., Brownlowe, K. B., & McAllister, T. W. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20200004 · Cited by 29 · see citing works
Depression following traumatic brain injury: a comprehensive overview
Fakhoury, M., Shakkour, Z., Kobeissy, F. H., & Lawand, N. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0037 · Cited by 28 · see citing works
Peppel, L. D., Ribbers, G. M., & Heijenbrok‐Kal, M. H. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6735 · Cited by 27 · see citing works
Mata-Bermúdez, A., Trejo-Chávez, R., Martínez-Vargas, M., Pérez-Arredondo, A., Martínez-Cárdenas, M. D. L. Á., Dı́az-Ruiz, A., Rı́os, C., & Navarro, L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1447688 · Cited by 26 · see citing works
Rauwenhoff, J., Peeters, F., Bol, Y., & Van Heugten, C. (2019) · Trials · doi:10.1186/s13063-019-3952-9 · Cited by 22 · see citing works
Treatment of Psychiatric Problems After Traumatic Brain Injury
Fann, J. R., Quinn, D. K., & Hart, T. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.008 · Cited by 24 · see citing works
Hicks, A. J., Clay, F. J., James, A. C., Hopwood, M., & Ponsford, J. L. (2022) · Neuropsychology Review · doi:10.1007/s11065-022-09543-6 · Cited by 22 · see citing works
Neurobiological Mechanisms Of Depression Following Traumatic Brain Injury
Jahan, A. B., & Tanev, K. S. (2022) · Brain Injury · doi:10.1080/02699052.2022.2145362 · Cited by 21 · see citing works
Pharmacotherapy Effectiveness in Treating Depression After Traumatic Brain Injury: A Meta-Analysis
Slowinski, A., Coetzer, R., & Byrne, C. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.18070158 · Cited by 21 · see citing works
Adolescent athletes and suicide: A model for treatment and prevention
Edmonds, W. A., Craig, L. L., Christopher, R., Kennedy, T. D., & Mann, D. T. Y. (2021) · Aggression and Violent Behavior · doi:10.1016/j.avb.2021.101580 · Cited by 21 · see citing works
Cheng, Y.-S., Tseng, P.-T., Wu, Y.-C., Tu, Y.-K., Wu, C.-K., Hsu, C.-W., Lei, W.-T., Li, D.-J., Chen, T.-Y., Stubbs, B., et al. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190122 · Cited by 16 · see citing works
Sergeyenko, Y., Andreae, M. E., & Segal, M. (2025) · Current Pain and Headache Reports · doi:10.1007/s11916-024-01333-4 · Cited by 16 · see citing works
Collins, S. M., O’Connell, C. J., Reeder, E. L., Norman, S. V., Lungani, K., Gopalan, P., Gudelsky, G. A., & Robson, M. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.930346 · Cited by 15 · see citing works
Traumatic brain injury, abnormal growth hormone secretion, and gut dysbiosis
Armstrong, P. A., Venugopal, N. K., Wright, T. J., Randolph, K. M., Batson, R. D., Yuen, K. C. J., Masel, B. E., Sheffield‐Moore, M., Urban, R. J., & Pyles, R. B. (2023) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2023.101841 · Cited by 14 · see citing works
Treatment and Rehabilitation for Traumatic Brain Injury: Current Update
Min, J. H., & Shin, Y. (2022) · Brain & Neurorehabilitation · doi:10.12786/bn.2022.15.e14 · Cited by 16 · see citing works
Luo, L., Langley, C., Moreno-López, L., Kendrick, K. M., Menon, D. K., Stamatakis, E. A., & Sahakian, B. J. (2021) · Psychological Medicine · doi:10.1017/s0033291721004724 · Cited by 12 · see citing works
Treatment of Depression after Traumatic Brain Injury Reduces Risk of Neuropsychiatric Outcomes
Albrecht, J. S., Lydecker, A. D., Peters, M. E., & Rao, V. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6957 · Cited by 12 · see citing works
Siwek, M., Gorostowicz, A., Bosak, M., & Dudek, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.852042 · Cited by 10 · see citing works
Mata-Bermúdez, A., Trejo-Chávez, R., Martínez-Vargas, M., Pérez-Arredondo, A., Martínez-Cárdenas, M. D. L. Á., Dı́az-Ruiz, A., Rı́os, C., Romero-Sánchez, H. A., Martínez‐Antonio, A., & Navarro, L. (2024) · Biomedicine · doi:10.37796/2211-8039.1461 · Cited by 8 · see citing works
Esterov, D., Lennon, R. J., Bergquist, T. F., & Brown, A. W. (2020) · Neurorehabilitation · doi:10.3233/nre-203082 · Cited by 8 · see citing works
Reyes, N. G. D., Espiritu, A. I., & Anlacan, V. M. M. (2019) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2019.03.024 · Cited by 7 · see citing works
Killgore, W. D. S. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1814147 · Cited by 6 · see citing works
Hicks, A. J., Clay, F. J., Hopwood, M., James, A. C., Perry, L. A., Jayaram, M., Batty, R., & Ponsford, J. L. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2020.7277 · Cited by 5 · see citing works
Mood Disorders in Young People With Acquired Brain Injury: An Integrated Model
Roberts, H., Ford, T. J., Karl, A., Reynolds, S. A., Limond, J., & Adlam, A. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.835897 · Cited by 5 · see citing works
Flerlage, W. J., Simmons, S. C., Thomas, E. H., Gouty, S., Tsuda, M. C., Wu, T. J., Armstrong, R. C., Cox, B. M., & Nugent, F. S. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2024.0184 · Cited by 5 · see citing works
Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries
Unadkat, P., Rebeiz, T. J., Ajmal, E., Souza, V. D., Xia, A., Jinu, J., Powell, K., & Li, C. (2025) · Cells · doi:10.3390/cells14020074 · Cited by 6 · see citing works
Hicks, A. J., Clay, F. J., James, A. C., Hopwood, M., & Ponsford, J. L. (2021) · JBI Evidence Synthesis · doi:10.11124/jbies-20-00363 · Cited by 4 · see citing works
Receipt of Treatment for Depression Following Traumatic Brain Injury
Albrecht, J. S., Abariga, S. A., dosReis, S., Perfetto, E. M., Mullins, C. D., & Rao, V. (2020) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000558 · Cited by 3 · see citing works
Khosravi, M. H., Louras, M., Martens, G., Kaux, J., Thibaut, A., & Lejeune, N. (2024) · Biomedicines · doi:10.3390/biomedicines12020450 · Cited by 3 · see citing works
Baltazar, V. A., Demchenko, I., Tassone, V. K., Sousa-Ho, R. L., Schweizer, T. A., & Bhat, V. (2024) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2024.1465612 · Cited by 3 · see citing works
Zhang, S., Afshar, H. T., Colvonen, P. J., Nokes, B. T., Compton, J. N., Mishra, J., Bismark, A. W., Ramanathan, D., & Koloski, M. F. (2025) · CNS Drugs · doi:10.1007/s40263-025-01180-w · Cited by 2 · see citing works
Tranchida, N., Inferrera, F., Cuzzocrea, S., Cordaro, M., & Paola, R. D. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111458 · Cited by 2 · see citing works
Winter, L., Moriarty, H., & Robinson, K. M. (2020) · International Journal of Therapy and Rehabilitation · doi:10.12968/ijtr.2019.0054 · Cited by 2 · see citing works
Ceniti, A. K., Rizvi, S. J., & Kennedy, S. H. (2022) · Springer eBooks · doi:10.1007/978-3-030-93813-0_7 · Cited by 2 · see citing works
Arciniegas, D. B., Seel, R. T., Macciocchi, S. N., Cifu, D. X., Frazier, Y. G., Kaelin, D. L., Katz, D. I., Oyesanya, T. O., & Wagner, A. K. (2025) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2025.08.024 · Cited by 1 · see citing works
Zhang, W., Ai, M., Takshe, A. A., & Muwafak, B. M. (2021) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2021283 · Cited by 1 · see citing works
Reeder, E. L., O’Connell, C. J., Collins, S. M., Traubert, O. D., Norman, S. V., Caceres, R. A., Sah, R., Smith, D. W., & Robson, M. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.10.016 · Cited by 1 · see citing works
Neuropsychiatry and Traumatic Brain Injury
Scicutella, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-16613-7_10
Koponen, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-39383-0_79
Anxiety and depression in people with acquired brain injury
Rauwenhoff, J. C. C. (2022) · doi:10.26481/dis.20221130jr
Mata-Bermúdez, A., Trejo-Chávez, R., Martínez-Vargas, M., Pérez-Arredondo, A., Martínez-Cárdenas, M. D. L. Á., Dı́az-Ruiz, A., Rı́os, C., Romero-Sánchez, H. A., Martínez‐Antonio, A., & Navarro, L. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4524594
Etiology and treatment challenges for neurotraumatic and psychiatric disorders
Arulsamy, A., & Shaikh, M. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13474-6.00006-8
Etiology and treatment challenges for neurotraumatic and psychiatric disorders
Arulsamy, A., & Shaikh, M. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00002-9
Liu, Y., Cao, X., Yang, T., Liang, Y., Liu, S., Ma, X., & Chen, J. (2025) · Research Square · doi:10.21203/rs.3.rs-7569661/v1
Dugas, J., Ernst, N., & Nield, L. S. (2025) · Southern Medical Journal · doi:10.14423/smj.0000000000001874
Thomas, E. H., Smith, T. E., Szabò, L. Z., Flerlage, W. J., Al‐Obeidi, F., Rujan, O. L., Gouty, S., Armstrong, R. C., Cox, B. M., Falk, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.05.692609
Outpatient rehabilitation can prevent suicide after acquired brain injury
Sörbo, A., & Björklund, R. (2026) · Journal of Rehabilitation Medicine · doi:10.2340/jrm.v58.45256
Nahmoud, I., Monahan, K., Woodcock, E. A., & Conti, A. C. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101314
Mulvaney, S. W., Mahadevan, S., Dineen, K. J., Desronvilles, R. J., & Truett, J. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1924374
- Authors
- Kreitzer, N., Ancona, R., McCullumsmith, C., Kurowski, B. G., Foreman, B., Ngwenya, L. B., & Adeoye, O.
- Affiliations
- University of Cincinnati (US)
- ORCID
- Venue
- Journal of Head Trauma Rehabilitation
- Published
- 2019-05
- Volume
- 34
- Issue
- 3
- Pages
- E47-E54
- ISSN
- 0885-9701 (ISSN-L)
- PMC
- PMC8730802
- OpenAlex
- W2889109390
- Cited by
- 56
- References
- 65
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 6
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Head Trauma Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (T32NS047996)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- antidepressants, traumatic brain injury, post-traumatic depression, major depressive disorder, pharmacotherapy, Hamilton Depression Rating Scale, depression treatment
- MeSH terms
- Brain Injuries, Traumatic, Antidepressive Agents, Depressive Disorder, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
