Cited by 126Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesCognitive Abilities and Testing

Practice effects predict cognitive outcome in amnestic mild cognitive impairment

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Duff, Kevin, Lyketsos, Constantine G., Beglinger, Leigh J., Chelune, Gordon, Moser, David J., Arndt, Stephan, Schultz, Susan K., Paulsen, Jane S. +2 more·2011·The American Journal of Geriatric Psychiatry

Abstract

Objective Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI.Design Longitudinal, observational design following participants across 1 year.Setting Community-based cohort.Participants Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26).Measurements Neuropsychological tests.Results After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition.Conclusions Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.

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Authors
Duff, K., Lyketsos, C. G., Beglinger, L. J., Chelune, G., Moser, D. J., Arndt, S., Schultz, S. K., Paulsen, J. S., Petersen, R. C., & McCaffrey, R. J.
Affiliations
  • University of Utah (US)
  • Johns Hopkins University (US)
  • University of Iowa (US)
  • Mayo Clinic (US)
  • University at Albany, State University of New York (US)
Corresponding author
Duff, Kevin
Venue
The American Journal of Geriatric Psychiatry
Publisher
Elsevier BV
Published
2011-11
Volume
19
Issue
11
Pages
932-939
ISSN
1064-7481 (ISSN-L)
OpenAlex
W2084040181
Cited by
126
References
25
Citations by year
2026: 7 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 12 · 2014: 3 · 2013: 5 · 2012: 5
FWCI
3.06
Type
journal article
Language
en
Open access
Locations
  • American Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (K23AG028417, P50AG005)
  • National Cancer Institute (R01CA122934)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
amnestic mild cognitive impairment, practice effects, cognitive decline, prognosis, older adults, memory, language, cognitive outcome prediction
MeSH terms
Aged, Aged, 80 and over, Amnesia, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Practice, Psychological, Predictive Value of Tests, Prognosis, Psychomotor Performance, Cognitive Dysfunction

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