Life Space and Risk of Alzheimer Disease, Mild Cognitive Impairment, and Cognitive Decline in Old Age
Open accessAbstract
Objective To test the hypothesis that a constricted life space, the extent of movement through the environment covered during daily functioning, is associated with increased risk of incident Alzheimer disease (AD), increased risk of mild cognitive impairment (MCI), and more rapid cognitive decline in older adults.Design Two prospective cohort studies.Setting Retirement communities, community-based organizations, churches, and senior subsidized housing facilities across the Chicago metropolitan area.Participants A total of 1,294 community-dwelling elders without baseline clinical dementia.Main outcome measures Detailed annual clinical evaluation to diagnose incident AD and MCI, and document change in cognitive function.Results During a mean (SD) follow-up of 4.4 (1.7) years, 180 persons developed AD. In a proportional hazards model controlling for age, sex, race, and education, a more constricted life space was associated with an increased risk of AD (hazard ratio = 1.21, confidence interval: 1.08-1.36). A person with a life space constricted to their home was almost twice as likely to develop AD than a person with the largest life space (out of town). The association did not vary along demographic lines and persisted after the addition of terms for performance-based physical function, disability, depressive symptoms, social network size, vascular disease burden, and vascular risk factors. The association remained consistent after excluding persons with MCI at baseline and who developed AD in the first 2 years of observation. A constricted life space was also associated with an increased risk of MCI (hazard ratio = 1.17, confidence interval: 1.06-1.28), and a more rapid rate of global cognitive decline (estimate: -0.012, standard error: 0.003, t[5033] = -3.58, p <0.001).Conclusions A constricted life space is associated with increased risk of AD, MCI, and cognitive decline among older persons.
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Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875 · see citing works
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320902 · Cited by 4,083 · see citing works
Two Shorter Forms of the CES-D Depression Symptoms Index
Kohout, F. J., Berkman, L. F., Evans, D. A., & Cornoni‐Huntley, J. C. (1993) · Journal of Aging and Health · doi:10.1177/089826439300500202 · Cited by 2,292 · see citing works
Neuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works
Self-citationA Measure of Primary Sociobiological Functions
Katz, S., & Akpom, C. A. (1976) · International Journal of Health Services · doi:10.2190/uurl-2ryu-wryd-ey3k · Cited by 1,232 · see citing works
Measuring Life‐Space Mobility in Community‐Dwelling Older Adults
Baker, P. S., Bodner, E. V., & Allman, R. M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51512.x · Cited by 957 · see citing works
Influence of leisure activity on the incidence of Alzheimer's disease
Scarmeas, N., Levy, G., Tang, M.-X., Manly, J., & Stern, Y. (2001) · Neurology · doi:10.1212/wnl.57.12.2236 · Cited by 831 · see citing works
Bennett, D. A., Schneider, J. A., Tang, Y., Arnold, S. E., & Wilson, R. S. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70417-3 · Cited by 718 · see citing works
Self-citationDepressive symptoms, cognitive decline, and risk of AD in older persons
Wilson, R. S., Barnes, L. L., Mendes de Leon, C. F., Aggarwal, N. T., Schneider, J. S., Bach, J., Pilat, J., Beckett, L. A., Arnold, S. E., Evans, D. A., et al. (2002) · Neurology · doi:10.1212/wnl.59.3.364 · Cited by 528 · see citing works
Self-citationFried, L. P. (2004) · Journal of Urban Health: Bulletin of the New York Academy of Medicine · doi:10.1093/jurban/jth094 · Cited by 523 · see citing works
Schooler, C., Mulatu, M. S., & Oates, G. (1999) · Psychology and Aging · doi:10.1037/0882-7974.14.3.483 · Cited by 435 · see citing works
Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
Buchman, A. S., Boyle, P. A., Wilson, R. S., Tang, Y., & Bennett, D. A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318068de1d · Cited by 420 · see citing works
Self-citationThe Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study Cohort
Bennett, D. A., Schneider, J. A., Buchman, A. S., de Leon, C. F. M., Bienias, J. L., & Wilson, R. S. (2005) · Neuroepidemiology · doi:10.1159/000087446 · Cited by 405 · see citing works
Self-citationSchooler, C., Mulatu, M. S., & Oates, G. L. S. C. (1999) · Psychology and Aging · doi:10.1037//0882-7974.14.3.483 · Cited by 356 · see citing works
Early and late life cognitive activity and cognitive systems in old age
WILSON, R. S., BARNES, L. L., KRUEGER, K. R., HOGANSON, G., BIENIAS, J. L., & BENNETT, D. A. (2005) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617705050459 · Cited by 355 · see citing works
Self-citationPerformance-based physical function and future dementia in older people
Wang, L., Larson, E. B., Bowen, J. D., & van Belle, G. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1115 · Cited by 329 · see citing works
The Life Space Questionnaire: A Measure of the Extent of Mobility of Older Adults
Stalvey, B. T., Owsley, C. J., Sloane, M. E., & Ball, K. (1999) · Journal of Applied Gerontology · doi:10.1177/073346489901800404 · Cited by 327 · see citing works
Conscientiousness and the Incidence of Alzheimer Disease and Mild Cognitive Impairment
Wilson, R. S., Schneider, J. A., Arnold, S. E., Bienias, J. L., & Bennett, D. A. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1204 · Cited by 276 · see citing works
Self-citationCognitive Functioning and Social Structure Over the Life Course.
Howard, J. A., Schooler, C., & Schaie, K. W. (1989) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2072004 · Cited by 274 · see citing works
Physical frailty in older persons is associated with Alzheimer disease pathology
Buchman, A. S., Schneider, J. A., Leurgans, S. E., & Bennett, D. A. (2008) · Neurology · doi:10.1212/01.wnl.0000324864.81179.6a · Cited by 260 · see citing works
Self-citationXue, Q., Fried, L. P., Glass, T. A., Laffan, A., & Chaves, P. H. M. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm270 · Cited by 247 · see citing works
Response of the brain to enrichment
Diamond, M. C. (2001) · Anais da Academia Brasileira de Ciências · doi:10.1590/s0001-37652001000200006 · Cited by 246 · see citing works
Complexity of Work and Risk of Alzheimer's Disease: A Population-Based Study of Swedish Twins
Andel, R., Crowe, M., Pedersen, N., Mortimer, J. A., Crimmins, E. M., Johansson, B. E. A., & Gatz, M. (2005) · The Journals of Gerontology Series B · doi:10.1093/geronb/60.5.p251 · Cited by 240 · see citing works
Psychological effects of complex environments during the life span: A review and theory
Schooler, C. (1984) · Intelligence · doi:10.1016/0160-2896(84)90011-4 · Cited by 216 · see citing works
Likelihood calculations for matched case-control studies and survival studies with tied death times
Gail, M. H., Lubin, J. H., & Rubinstein, L. (1981) · Biometrika · doi:10.1093/biomet/68.3.703 · Cited by 207 · see citing works
The life-space diary: A measure of mobility in old people at home
May, D., Nayak, U. S., & Isaacs, B. (1985) · International Rehabilitation Medicine · doi:10.3109/03790798509165993 · Cited by 192 · see citing works
Neuroprotective effects of cognitive enrichment
Milgram, N. W., Siwak-Tapp, C. T., Araujo, J., & Head, E. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.004 · Cited by 146 · see citing works
Correlates of Life Space in a Volunteer Cohort of Older Adults
Barnes, L. L., Wilson, R. S., Bienias, J. L., de Leon, C. F. M., Kim, H.-J. N., Buchman, A. S., & Bennett, D. A. (2006) · Experimental Aging Research · doi:10.1080/03610730601006420 · Cited by 145 · see citing works
Self-citationCrowe, M., Andel, R., Wadley, V. G., Okonkwo, O. C., Sawyer, P., & Allman, R. M. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.11.1241 · Cited by 144 · see citing works
Glass, T. A. (1998) · The Gerontologist · doi:10.1093/geront/38.1.101 · Cited by 143 · see citing works
The Nursing Home Life‐Space Diameter
Tinetti, M. E., & Ginter, S. F. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03453.x · Cited by 130 · see citing works
Allman, R. M., Sawyer, P., & Roseman, J. M. (2006) · Aging Health · doi:10.2217/1745509x.2.3.417 · Cited by 108 · see citing works
Later Life: The Realities of Aging
Bairan, A., & Cox, H. (1989) · Teaching Sociology · doi:10.2307/1317943 · Cited by 97 · see citing works
Diabetes and Cognitive Systems in Older Black and White Persons
Arvanitakis, Z., Bennett, D. A., Wilson, R. S., & Barnes, L. L. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181a6bed5 · Cited by 76 · see citing works
Self-citationLower Extremity Motor Function and Disability in Mild Cognitive Impairment
Boyle, P. A., Wilson, R. S., Buchman, A. S., Aggarwal, N. T., Tang, Y., Arvanitakis, Z., Kelly, J., & Bennett, D. A. (2007) · Experimental Aging Research · doi:10.1080/03610730701319210 · Cited by 68 · see citing works
Self-citationFactors Associated With Life Space Among Community‐Living Rural Elders in Japan
Murata, C., Kondo, T., Tamakoshi, K., Yatsuya, H., & Toyoshima, H. (2006) · Public Health Nursing · doi:10.1111/j.1525-1446.2006.00568.x · Cited by 62 · see citing works
Rn, B. (2000) · PubMed · Cited by 32 · see citing works
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Social Isolation and Cognitive Function in Later Life: A Systematic Review and Meta-Analysis
Evans, I. E. M., Martyr, A., Collins, R., Brayne, C., & Clare, L. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180501 · Cited by 531 · see citing works
Are loneliness and social isolation associated with cognitive decline?
Lara, E., Caballero, F. F., Rico‐Uribe, L. A., Olaya, B., Haro, J. M., Ayuso‐Mateos, J. L., & Miret, M. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5174 · Cited by 423 · see citing works
Hersi, M., Irvine, B., Gupta, P., Gomes, J., Birkett, N., & Krewski, D. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.03.006 · Cited by 332 · see citing works
Kuiper, J. S., Zuidersma, M., Zuidema, S. U., Burgerhof, J. G. M., Stolk, R. P., Oude Voshaar, R. C., & Smidt, N. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw089 · Cited by 301 · see citing works
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Han, S. D., Boyle, P. A., James, B. D., Yu, L., & Bennett, D. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150442 · Cited by 117 · see citing works
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Shang, Y., Wu, Z., Du, X., Jiang, Y., Ma, B., & Chi, M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.912242 · Cited by 86 · see citing works
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Mishra, P., Davies, D. A., & Albensi, B. C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03152-3 · Cited by 51 · see citing works
Grey matter correlates of susceptibility to scams in community-dwelling older adults
Duke Han, S., Boyle, P. A., Yu, L., Arfanakis, K., James, B. D., Fleischman, D. A., & Bennett, D. A. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9422-4 · Cited by 42 · see citing works
Self-citationWu, J., Hasselgren, C., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I., & Halleröd, B. (2020) · Aging & Mental Health · doi:10.1080/13607863.2018.1531368 · Cited by 18 · see citing works
- Authors
- James, B. D., Boyle, P. A., Buchman, A. S., Barnes, L. L., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- James, Bryan D.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 19
- Issue
- 11
- Pages
- 961-969
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC3123692
- OpenAlex
- W1976949208
- Cited by
- 177
- References
- 38
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 16 · 2023: 12 · 2022: 15 · 2021: 21 · 2020: 12 · 2019: 12 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 21 · 2014: 4 · 2013: 9 · 2012: 14
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG017917, R01-AG-24480, R01‐AG17917, R01AG22018, R01AG024480, R01AG033678, R01AG034374, R01AG022018)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- life space, Alzheimer's disease, mild cognitive impairment, cognitive decline, older adults, physical activity, mobility, environmental activities, dementia risk, community-dwelling older adults
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Female, Follow-Up Studies, Humans, Male, Risk Factors, Social Environment, Proportional Hazards Models, Cognitive Dysfunction
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