The DOI matches its Crossref record, with a small difference in title or year; 64 of the 64 references it cites were found in a registry or an index.
Recommendations for Probiotic Use—2015 Update: Proceedings and Consensus Opinion
Open accessAbstract
This paper describes the consensus opinion of the participants in the 4th Triennial Yale/Harvard Workshop on Probiotic Recommendations. The recommendations update those of the first 3 meetings that were published in 2006, 2008, and 2011. Recommendations for the use of probiotics in necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome and Clostridium difficile diarrhea are reviewed. In addition, we have added recommendations for liver disease for the first time. As in previous publications, the recommendations are given as A, B, or C ratings.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Our findings do not support recommendations for the use of specific probiotics for acute infectious diarrhoea in children (Floch 2015; Guarino 2018; Sniffen 2018).”
From Probiotics for treating acute infectious diarrhoea (2020) · cites this paper as Floch 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Self-citationKruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147
Rembacken, B., Snelling, A. M., Hawkey, P. M., Chalmers, D. M., & Axon, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06343-0 · Cited by 1,100
Treating Clostridium difficile infection with fecal microbiota transplantation
Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., Kelly, C., Khoruts, A., Louie, T., Martinelli, L. P., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.08.014 · Cited by 1,003
Self-citationGuarino, A., Ashkenazi, S., Gendrel, D., Lo Vecchio, A., Shamir, R., & Szajewska, H. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000375 · Cited by 935
Self-citationMimura, T., Rizzello, F., Helwig, U., Poggioli, G., Schreiber, S., Talbot, I. C., Nicholls, R. J., Gionchetti, P., Campieri, M., & Kamm, M. A. (2003) · Gut · doi:10.1136/gut.53.1.108 · Cited by 912
Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799
Self-citationVSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis
Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743
Saccharomyces boulardii in Maintenance Treatment of Crohn’s Disease
Guslandi, M., Mezzi, G., Sorghi, M., & Testoni, P. A. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005588911207 · Cited by 722
Self-citationLoftus, C. G., Loftus, E. V., Harmsen, S. W., Zinsmeister, A. R., Tremaine, W. J., Melton, J. L., & Sandborn, W. J. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20029 · Cited by 638
Youngster, I., Russell, G. H., Pindar, C., Ziv-Baran, T., Sauk, J., & Hohmann, E. L. (2014) · JAMA · doi:10.1001/jama.2014.13875 · Cited by 629
Hickson, M., D'Souza, A. L., Muthu, N., Rogers, T. R., Want, S., Rajkumar, C., & Bulpitt, C. J. (2007) · BMJ · doi:10.1136/bmj.39231.599815.55 · Cited by 599
Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517
Lin, H.-C., Hsu, C.-H., Chen, H.-L., Chung, M.-Y., Hsu, J.-F., Lien, R.-I., Tsao, L.-Y., Chen, C.-H., & Su, B.-H. (2008) · Pediatrics · doi:10.1542/peds.2007-3007 · Cited by 506
Niedzielin, K., Kordecki, H., & Birkenfeld, B. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200110000-00004 · Cited by 506
Kim, H. J., Camilleri, M., Mckinzie, S., Lempke, M. B., Burton, D. D., Thomforde, G. M., & Zinsmeister, A. R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01543.x · Cited by 468
Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis
Malaguarnera, M., Vacante, M., Antic, T., Giordano, M., Chisari, G., Acquaviva, R., Mastrojeni, S., Malaguarnera, G., Mistretta, A., Volti, G. L., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1887-4 · Cited by 459
Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases
Loguercio, C., Federico, A., Tuccillo, C., Terracciano, F., D’Auria, M. V., Simone, C. D., & Blanco, C. D. V. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000165671.25272.0f · Cited by 450
Gupta, P., Andrew, H., Kirschner, B. S., & Guandalini, S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200010000-00024 · Cited by 429
Crohn's Disease and Escherichia coli
Malchow, H. A. (1997) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199712000-00021 · Cited by 402
Kim, H. J., Vazquez Roque, M. I., Camilleri, M., Stephens, D., Burton, D. D., Baxter, K., Thomforde, G., & Zinsmeister, A. R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00695.x · Cited by 400
Aller, R., de Luis, D. A., Izaola, O., Conde, R., Sagrado, M. G., Primo, D., Fuente, B. D. L., & González‐Gallego, J. (2011) · PubMed · Cited by 371
Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG
Isolauri, E., Joensuu, J., Suomalainen, H., Luomala, M., & Vesikari, T. (1995) · Vaccine · doi:10.1016/0264-410x(95)93319-5 · Cited by 370
GUYONNET, D., CHASSANY, O., DUCROTTE, P., PICARD, C., MOURET, M., MERCIER, C. ‐., & MATUCHANSKY, C. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03362.x · Cited by 365
Probiotics for Prevention and Treatment of Diarrhea
Guandalini, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182257e98 · Cited by 351
Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study
Wong, V. W., Wong, G. L., Chim, A. M., Chu, C. W., Yeung, D. K., Li, K. C.-T., & Chan, H. L. (2013) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31364-x · Cited by 323
Anukam, K. C., Osazuwa, E. O., Ahonkhai, I., Ngwu, M., Osemene, G. I., Bruce, A. W., & Reid, G. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.01.003 · Cited by 297
Ingestion of Yogurt Containing Lactobacillus acidophilus as Prophylaxis for Candidal Vaginitis
Hilton, E., Isenberg, H. D., Alperstein, P., France, K., & Borenstein, M. T. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-5-353 · Cited by 288
Use of Probiotics for Management of Acute Gastroenteritis
Szajewska, H., Guarino, A., Hojsak, I., Indrio, F., Kolaček, S., Shamir, R., Vandenplas, Y., & Weizman, Z. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000320 · Cited by 277
Self-citationAnukam, K. C., Osazuwa, E., Osemene, G. I., Ehigiagbe, F., Bruce, A. W., & Reid, G. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.08.008 · Cited by 276
Guandalini, S., Magazzù, G., Chiaro, A., La Balestra, V., Di Nardo, G., Gopalan, S., Sibal, A., Romano, C., Canani, R. B., Lionetti, P., et al. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181ca4d95 · Cited by 273
Agrawal, A., Sharma, B. C., Sharma, P., & Sarin, S. K. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.113 · Cited by 217
Mittal, V. V., Sharma, B. C., Sharma, P., & Sarin, S. K. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32834696f5 · Cited by 217
Probiotics for Prevention and Treatment of Diarrhea
Guarino, A., Guandalini, S., & Vecchio, A. L. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000349 · Cited by 217
Self-citationHigh-Dose Probiotics for the Treatment of Active Pouchitis
Gionchetti, P., Rizzello, F., Morselli, C., Poggioli, G., Tambasco, R., Calabrese, C., Brigidi, P., Vitali, B., Straforini, G., & Campieri, M. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-007-9068-4 · Cited by 212
Recommendations for Probiotic Use—2011 Update
Floch, M. H., Walker, W. A., Madsen, K. L., Sanders, M. E., Macfarlane, G. T., Flint, H. J., Dieleman, L. A., Ringel, Y., Guandalini, S., Kelly, C. P., et al. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318230928b · Cited by 208
Self-citationShukla, S., Shukla, A. K., Mehboob, S., & Guha, S. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04574.x · Cited by 197
Meta‐analysis: Saccharomyces boulardii for treating acute diarrhoea in children
Szajewska, H., Skórka, A., & Dyląg, M. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03202.x · Cited by 190
Salminen, E. K., Elomaa, I., Minkkinen, J., Vapaatalo, H., & Salminen, S. (1988) · Clinical Radiology · doi:10.1016/s0009-9260(88)80296-4 · Cited by 185
Delia, P., Sansotta, G., Donato, V., Messina, G., Frosina, P., Pergolizzi, S., Renzis, C. D., & Famularo, G. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05946.x · Cited by 128
Probiotics for Prevention of Antibiotic-associated Diarrhea
Doron, S., Hibberd, P. L., & Gorbach, S. L. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181618ab7 · Cited by 119
Probiotics for the Prevention of Antibiotic-associated Diarrhea and Clostridium difficile Diarrhea
Katz, J. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00017 · Cited by 108
Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection
Brandt, L. J., & Reddy, S. S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318222e603 · Cited by 99
Self-citationRole of Gut Microbiota in Liver Disease
Brenner, D. A., Paik, Y., & Schnabl, B. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000391 · Cited by 94
Self-citationProbiotics in Clostridium difficile Infection
Na, X., & Kelly, C. P. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31822ec787 · Cited by 88
Szajewska, H., Urbańska, M., Chmielewska, A., Weizman, Z., & Shamir, R. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0056 · Cited by 76
Probiotics: Use in Allergic Disorders
Isolauri, E., & Salminen, S. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181639a98 · Cited by 75
Probiotics in the Management of Ulcerative Colitis
Chibbar, R., & Dieleman, L. A. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000368 · Cited by 74
Self-citationSurawicz, C. M. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181646d09 · Cited by 62
Probiotics in the Prevention of Necrotizing Enterocolitis
Ganguli, K. A., & Walker, W. A. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318228b799 · Cited by 60
Self-citationThe Intestinal Microbiota and Irritable Bowel Syndrome
Ringel, Y., & Ringel‐Kulka, T. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000418 · Cited by 55
Self-citationSanders, M. E. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000350 · Cited by 46
Self-citationProbiotics in Irritable Bowel Syndrome
Quigley, E. M. M. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000348 · Cited by 41
Self-citationRole of Probiotics in Crohn’s Disease and in Pouchitis
Guslandi, M. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000351 · Cited by 31
Self-citationKim, A. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000356 · Cited by 29
Self-citationGut Microbiota and Energy Expenditure in Health and Obesity
Bakker, G. J., Zhao, J., Herrema, H., & Nieuwdorp, M. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000363 · Cited by 26
Self-citationFrom Birth to “Immunohealth,” Allergies and Enterocolitis
Houghteling, P. D., & Walker, W. A. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000355 · Cited by 26
Self-citationBrandt, L. J. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000346 · Cited by 22
Self-citationProbiotics in Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, and Cirrhosis
Qamar, A. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000347 · Cited by 16
Self-citationProbiotics in Pediatric Liver Disease
Miloh, T. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000365 · Cited by 11
Self-citation
Research works printed but not linked: 1
- Anukam, 2006, . Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis., Microbes Infect, 8, 2772, 10.1016/j.micinf.2006.08.008 · DOI · Paper page
Cited by
Sorted by citations
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,143
ESPEN guideline: Clinical nutrition in inflammatory bowel disease
Forbes, A., Escher, J., Hébuterne, X., Kłęk, S., Krznaric, Z., Schneider, S., Shamir, R., Stardelova, K., Wierdsma, N., Wiskin, A. E., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.12.027 · Cited by 625
RetractedNecrotizing enterocolitis: new insights into pathogenesis and mechanisms
Niño, D. F., Sodhi, C. P., & Hackam, D. J. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.119 · Cited by 621
Lifestyles in transition: evolution and natural history of the genus Lactobacillus
Duar, R. M., Lin, X. B., Zheng, J., Martino, M. E., Grenier, T., Pérez-Muñoz, M. E., Leulier, F., Gänzle, M. G., & Walter, J. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux030 · Cited by 567
Intestinal Lactobacillus in health and disease, a driver or just along for the ride?
Heeney, D. D., Gareau, M. G., & Marco, M. L. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.08.004 · Cited by 367
Metadata
- Authors
- Floch, M. H., Walker, W. A., Sanders, M. E., Nieuwdorp, M., Kim, A. S., Brenner, D. A., Qamar, A. A., Miloh, T. A., Guarino, A., Guslandi, M., Dieleman, L. A., Ringel, Y., Quigley, E. M. M., & Brandt, L. J.
- Affiliations
- Lahey Hospital and Medical Center (US)
- Harvard University (US)
- Amsterdam UMC Location University of Amsterdam (NL)
- MNGI Digestive Health (US)
- Yale University (US)
- University of Gothenburg (SE)
- Massachusetts General Hospital (US)
- Corresponding author
- Floch, Martin H.
- Brenner, David A.
- Dieleman, Levinus A.
- ORCID
- Venue
- Journal of Clinical Gastroenterology
- Published
- 2015-11
- Volume
- 49
- Issue
- Supplement 1
- Pages
- S69-S73
- ISSN
- 0192-0790 (ISSN-L)
- OpenAlex
- W2199248144
- Semantic Scholar
- fbce8a5e5d792c961602f656b449e7da6574b22c
- Cited by
- 119
- References
- 64
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 24 · 2016: 18 · 2015: 1
- FWCI
- 24.97
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Journal of Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institutes of Health (DK040561)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK033506, P30DK040561, T32DK007191)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD059126, R01HD012437)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, clinical guidelines, necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome, Clostridium difficile-associated diarrhea, liver disease, probiotic therapy
- MeSH terms
- Adult, Child, Diarrhea, Enterocolitis, Pseudomembranous, Humans, Liver Diseases, Clostridioides difficile, Probiotics, Enterocolitis, Necrotizing, Irritable Bowel Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review