Functional roles of the sweet taste receptor in oral and extraoral tissues
Open accessAbstract
PURPOSE OF REVIEW: This review summarizes and discusses the current knowledge about the physiological roles of the sweet taste receptor in oral and extraoral tissues. RECENT FINDINGS: The expression of a functional sweet taste receptor has been reported in numerous extragustatory tissues, including the gut, pancreas, bladder, brain and, more recently, bone and adipose tissues. In the gut, this receptor has been suggested to be involved in luminal glucose sensing, the release of some satiety hormones, the expression of glucose transporters, and the maintenance of glucose homeostasis. More recently, the sweet taste receptor was proposed to regulate adipogenesis and bone biology. SUMMARY: The perception of sweet taste is mediated by the T1R2/T1R3 receptor, which is expressed in the oral cavity, wherein it provides input on the caloric and macronutrient contents of ingested food. This receptor recognizes all the chemically diverse compounds perceived as sweet by human beings, including natural sugars and sweeteners. Importantly, the expression of a functional sweet taste receptor has been reported in numerous extragustatory tissues, wherein it has been proposed to regulate metabolic processes. This newly recognized role of the sweet taste receptor makes this receptor a potential novel therapeutic target for the treatment of obesity and related metabolic dysfunctions, such as diabetes and hyperlipidemia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
STRs are documented widely in metabolic tissues that sense and respond to carbohydrates, including pancreatic β-cells, hepatocytes, adipocytes, and hypothalamic neurons.
“STRs are also documented widely in metabolic tissues that sense and respond to carbohydrates, such as pancreatic β-cells, hepatocytes, adipocytes, and hypothalamic neurons [for review, see (23,24)].”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 5× · see citing works
“Using murine enteroendocrine cell lines, when the T1R2/T1R3 receptor was inhibited by gurmarin, a sweet taste inhibitor in mice [6], GLP-1 and GIP secretion was further blocked, confirming the involvement of the sweet taste receptor in regulating the secretion of these incretins.”
BackgroundInfluentialMargolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882 · see citing works
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003) · Science · doi:10.1126/science.1087155 · Cited by 632 · see citing works
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
Max, M., Shanker, Y. G., Huang, L., Rong, M., Liu, Z., Campagne, F., Weinstein, H., Damak, S., & Margolskee, R. F. (2001) · Nature Genetics · doi:10.1038/ng0501-58 · Cited by 526 · see citing works
Dyer, J., Salmon, K. S. H., Zibrik, L., & Shirazi‐Beechey, S. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330302 · Cited by 383 · see citing works
Janssen, S., Laermans, J., Verhulst, P.-J., Thijs, T., Tack, J., & Depoortere, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011508108 · Cited by 317 · see citing works
Colocalization of the α-subunit of gustducin with PYY and GLP-1 in L cells of human colon
Rozengurt, N., Wu, S.-Z., Chen, M. C., Huang, C., Sternini, C., & Rozengurt, E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00074.2006 · Cited by 273 · see citing works
Sweet taste signaling functions as a hypothalamic glucose sensor
Ren, X. (2009) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.012.2009 · Cited by 267 · see citing works
Gustatory and extragustatory functions of mammalian taste receptors
Behrens, M., & Meyerhof, W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.010 · Cited by 233 · see citing works
Kyriazis, G. A., Soundarapandian, M. M., & Tyrberg, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115183109 · Cited by 233 · see citing works
Rozengurt, E. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00073.2006 · Cited by 220 · see citing works
Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart
Foster, S. R., Porrello, E. R., Purdue, B. W., Chan, H., Voigt, A., Frenzel, S., Hannan, R. D., Moritz, K. M., Simmons, D. G., Molenaar, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064579 · Cited by 154 · see citing works
T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach
Hass, N., Schwarzenbacher, K., & Breer, H. (2010) · Cell and Tissue Research · doi:10.1007/s00441-009-0907-6 · Cited by 139 · see citing works
Variation in the Human TAS1R Taste Receptor Genes
Kim, U.-K. (2006) · Chemical Senses · doi:10.1093/chemse/bjj065 · Cited by 130 · see citing works
Simon, B. R., Parlee, S. D., Learman, B. S., Mori, H., Scheller, E. L., Cawthorn, W. P., Ning, X., Gallagher, K. A., Tyrberg, B., Assadi‐Porter, F. M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.514034 · Cited by 129 · see citing works
The activation mechanism of class-C G-protein coupled receptors
Pin, J., Kniazeff, J., Goudet, C., Bessis, A. ‐., Liu, J., Galvez, T., Acher, F., Rondard, P., & Prézeau, L. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2004.03.005 · Cited by 115 · see citing works
Extrasensory perception: Odorant and taste receptors beyond the nose and mouth
Foster, S. R., Roura, E., & Thomas, W. G. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.004 · Cited by 112 · see citing works
Young, R. L., Chia, B., Isaacs, N. J., Ma, J., Khoo, J., Wu, T., Horowitz, M., & Rayner, C. K. (2013) · Diabetes · doi:10.2337/db13-0581 · Cited by 111 · see citing works
Masubuchi, Y., Nakagawa, Y. S., Ma, J., Sasaki, T., Kitamura, T., Yamamoto, Y., Kurose, H., Kojima, I., & Shibata, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054500 · Cited by 102 · see citing works
Fushan, A. A., Simons, C. T., Slack, J. P., & Drayna, D. T. (2010) · Chemical Senses · doi:10.1093/chemse/bjq063 · Cited by 101 · see citing works
The activation mechanism of class‐C G‐protein coupled receptors
Pin, J., Kniazeff, J., Goudet, C., et al. (2004) · Biology of the Cell · doi:10.1111/j.1768-322x.2004.tb01423.x · Cited by 90 · see citing works
Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
Shirazi‐Beechey, S. P., Daly, K., Al-Rammahi, M. A., Moran, A. W., & Bravo, D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002286 · Cited by 85 · see citing works
Nakagawa, Y. S., Nagasawa, M., Mogami, H., Lohse, M. J., Ninomiya, Y., & Kojima, I. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0282 · Cited by 84 · see citing works
Meyer, D., Voigt, A., Widmayer, P., Borth, H., Huebner, S., Breit, A., Marschall, S., de Angelis, M. H., Boehm, U., Meyerhof, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032354 · Cited by 77 · see citing works
Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass
Simon, B. R., Learman, B. S., Parlee, S. D., Scheller, E. L., Mori, H., Cawthorn, W. P., Ning, X., Krishnan, V., Ma, Y. L., Tyrberg, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086454 · Cited by 76 · see citing works
Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility
Mosinger, B. J., Redding, K., Parker, M. R., Yevshayeva, V., Yee, K. K., Dyomina, K., Li, Y., & Margolskee, R. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302827110 · Cited by 69 · see citing works
Elliott, R. A., Kapoor, S., & Tincello, D. G. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.07.083 · Cited by 68 · see citing works
Effects of Artificial Sweeteners on Insulin Release and Cationic Fluxes in Rat Pancreatic Islets
Malaisse, W. J., Onderbergen, A. V., Louchami, K., Jijakli, H., & MALAISSE-LAGAE, F. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00017-5 · Cited by 58 · see citing works
Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3
Nakagawa, Y. S., Ohtsu, Y., Nagasawa, M., Shibata, H., & Kojima, I. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0431 · Cited by 57 · see citing works
Sense of Taste in the Gastrointestinal Tract
Iwatsuki, K., & Uneyama, H. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11r08cp · Cited by 51 · see citing works
Maîtrepierre, E., Sigoillot, M., Pessot, L. L., et al. (2012) · Protein Expression and Purification · doi:10.1016/j.pep.2012.03.006 · Cited by 45 · see citing works
Sweet-taste-suppressing compounds: current knowledge and perspectives of application
Sigoillot, M., Brockhoff, A., Meyerhof, W., & Briand, L. V. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4387-3 · Cited by 43 · see citing works
Self-citationGeneration and characterization of T1R2-LacZ knock-in mouse
Iwatsuki, K., Nomura, M., Shibata, A., Ichikawa, R., Enciso, P. L. M., Wang, L., Takayanagi, R., Torii, K., & Uneyama, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.057 · Cited by 42 · see citing works
Do Pancreatic β Cells “Taste” Nutrients to Secrete Insulin?
Henquin, J. (2012) · Science Signaling · doi:10.1126/scisignal.2003325 · Cited by 41 · see citing works
Shin, Y., Park, J.-H., Choi, J., Chun, M., Moon, Y. W., & Lee, M. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0223-2 · Cited by 39 · see citing works
Tomonari, H., Miura, H., Nakayama, A., et al. (2011) · Chemical Senses · doi:10.1093/chemse/bjr098 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Enteroendocrine cells: a review of their role in brain–gut communication
Latorre, R., Sternini, C., De Giorgio, R., & Greenwood‐Van Meerveld, B. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12754 · Cited by 392 · see citing works
The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis
Pang, M. D., Goossens, G. H., & Blaak, E. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.598340 · Cited by 180 · see citing works
Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism
Burke, M. V., & Small, D. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.036 · Cited by 132 · see citing works
Frankenfeld, C. L., Sikaroodi, M., Lamb, E., Shoemaker, S., & Gillevet, P. M. (2015) · Annals of Epidemiology · doi:10.1016/j.annepidem.2015.06.083 · Cited by 123 · see citing works
Gut mechanisms linking intestinal sweet sensing to glycemic control
Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00741 · Cited by 40 · see citing works
“STRs are also documented widely in metabolic tissues that sense and respond to carbohydrates, such as pancreatic β-cells, hepatocytes, adipocytes, and hypothalamic neurons [for review, see (23, 24)].”
Background
- Authors
- Laffitte, A., Neiers, F., & Briand, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Briand, Loïc
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2014-07
- Volume
- 17
- Issue
- 4
- Pages
- 379-385
- ISSN
- 1363-1950 (ISSN-L)
- PMC
- PMC4059820
- OpenAlex
- W2030645331
- Cited by
- 238
- References
- 36
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 18 · 2023: 17 · 2022: 26 · 2021: 17 · 2020: 24 · 2019: 23 · 2018: 31 · 2017: 24 · 2016: 14 · 2015: 11 · 2014: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Recherche Agronomique
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- sweet taste receptor, T1R2/T1R3, oral cavity, glucose homeostasis, satiety hormones, glucose transporters, adipogenesis, bone biology, obesity, diabetes mellitus, hyperlipidemia, therapeutic target
- MeSH terms
- Insulin Secretion, Adipose Tissue, Animals, Urinary Bladder, Heart, Humans, Insulin, Lymphocytes, Polymorphism, Genetic, Protein Conformation, Sweetening Agents, Taste, Taste Buds, Models, Animal, Gastrointestinal Tract, Receptors, G-Protein-Coupled
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
