Enteroendocrine cells: a review of their role in brain–gut communication
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Background: Specialized endoderm‐derived epithelial cells, that is, enteroendocrine cells ( EEC s), are widely distributed throughout the gastrointestinal ( GI ) tract. Enteroendocrine cells form the largest endocrine organ in the body and play a key role in the control of GI secretion and motility, the regulation of food intake, postprandial glucose levels and metabolism. EEC s sense luminal content and release signaling molecules that can enter the circulation to act as classic hormones on distant targets, act locally on neighboring cells and on distinct neuronal pathways including enteric and extrinsic neurons. Recent studies have shed light on EEC sensory transmission by showing direct connections between EEC s and the nervous system via axon‐like processes that form a well‐defined neuroepithelial circuits through which EEC s can directly communicate with the neurons innervating the GI tract to initiate appropriate functional responses. Purpose: This review will highlight the role played by the EEC s in the complex and integrated sensory information responses, and discuss the new findings regarding EEC s in the brain–gut axis bidirectional communication.
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GLP-1 and PYY can stimulate satiation and inhibit eating, acting either directly on hypothalamic centers of appetite control or indirectly via the vagal-brainstem-hypothalamic pathway.
“GLP-1 and PYY can stimulate satiation and inhibit eating, acting either directly on the hypothalamic centers of appetite control, or indirectly via the vagal-brainstem-hypothalamic pathway (Latorre et al., 2016;Steinert et al., 2017).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Latorre et al., 2016
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Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication
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Cellular Composition and Differentiation Signaling in Chicken Small Intestinal Epithelium
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- Authors
- Latorre, R., Sternini, C., De Giorgio, R., & Greenwood‐Van Meerveld, B.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- University of California, Los Angeles (US)
- Department of Medical and Surgical Sciences University of Bologna Bologna Italy
- Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Oklahoma City OK USA
- Corresponding author
- Latorre, R.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2015-12-21
- Volume
- 28
- Issue
- 5
- Pages
- 620-630
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- PMC
- PMC4842178
- OpenAlex
- W2197572016
- Cited by
- 392
- References
- 102
- Citations by year
- 2026: 44 · 2025: 43 · 2024: 51 · 2023: 43 · 2022: 37 · 2021: 53 · 2020: 44 · 2019: 39 · 2018: 16 · 2017: 13 · 2016: 9
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P30 DK041301)
- CURE Childhood Cancer (RO1‐DK098447)
- University of California, Los Angeles
- U.S. Department of Veterans Affairs (VA Merit BX002188‐01, VA Merit BX001195‐05)
- Università di Bologna
- Fondazione del Monte di Bologna e Ravenna
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- enteroendocrine cells, gut-brain axis, gut-brain signaling, gastrointestinal hormones, enteric neurons, gastrointestinal secretion, gastrointestinal motility, food intake regulation, postprandial blood glucose, sensory signaling
- MeSH terms
- Brain, Cell Communication, Eating, Gastrointestinal Hormones, Humans, Neural Pathways, Enteroendocrine Cells, Gastrointestinal Tract
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