Cited by 392Gastrointestinal motility and disordersRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

Enteroendocrine cells: a review of their role in brain–gut communication

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Latorre, R., Sternini, C., De Giorgio, R., Greenwood‐Van Meerveld, B.·2016·Neurogastroenterology & Motility

Abstract

Background: Specialized endoderm‐derived epithelial cells, that is, enteroendocrine cells ( EEC s), are widely distributed throughout the gastrointestinal ( GI ) tract. Enteroendocrine cells form the largest endocrine organ in the body and play a key role in the control of GI secretion and motility, the regulation of food intake, postprandial glucose levels and metabolism. EEC s sense luminal content and release signaling molecules that can enter the circulation to act as classic hormones on distant targets, act locally on neighboring cells and on distinct neuronal pathways including enteric and extrinsic neurons. Recent studies have shed light on EEC sensory transmission by showing direct connections between EEC s and the nervous system via axon‐like processes that form a well‐defined neuroepithelial circuits through which EEC s can directly communicate with the neurons innervating the GI tract to initiate appropriate functional responses. Purpose: This review will highlight the role played by the EEC s in the complex and integrated sensory information responses, and discuss the new findings regarding EEC s in the brain–gut axis bidirectional communication.

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  • GLP-1 and PYY can stimulate satiation and inhibit eating, acting either directly on hypothalamic centers of appetite control or indirectly via the vagal-brainstem-hypothalamic pathway.

    “GLP-1 and PYY can stimulate satiation and inhibit eating, acting either directly on the hypothalamic centers of appetite control, or indirectly via the vagal-brainstem-hypothalamic pathway (Latorre et al., 2016;Steinert et al., 2017).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Latorre et al., 2016

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  1. [25]Dockray GJ The gut endocrine system and its control Exp Physiol 1994 79 5 607 34 7818855
  2. [38]Batterham RL Cohen Ma Ellis SM Le Roux CW Withers DJ Frost GS Ghatei MA Bloom SR Inhibition of food intake in obese subjects by peptide YY3-36 N Engl J Med 2003 349 10 941 8 12954742
  3. [86]Whited KL Tso P Raybould HE Involvement of apolipoprotein A-IV and CCk1 receptor in exogenous PYY3-36-induced stimulation of intestinal feedback Endocrinology 2007 148 10 4695 4703 17641001
  4. [98]Gilet M Eutamene H Han H Kim HW Bueno L Influence of new 5-HT4 receptor partial agonist, YKP10811, on visceral hypersensitivity in rats triggered by stress and inflammation. 2014 Neurogastrenterol Motil 2014 26 12 1761 1770 25316608

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Authors
Latorre, R., Sternini, C., De Giorgio, R., & Greenwood‐Van Meerveld, B.
Affiliations
  • University of Oklahoma Health Sciences Center (US)
  • University of California, Los Angeles (US)
  • Department of Medical and Surgical Sciences University of Bologna Bologna Italy
  • Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Oklahoma City OK USA
Corresponding author
Latorre, R.
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2015-12-21
Volume
28
Issue
5
Pages
620-630
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
OpenAlex
W2197572016
Cited by
392
References
102
Citations by year
2026: 44 · 2025: 43 · 2024: 51 · 2023: 43 · 2022: 37 · 2021: 53 · 2020: 44 · 2019: 39 · 2018: 16 · 2017: 13 · 2016: 9
FWCI
2.22
Type
journal article
Language
en
Open access
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (P30 DK041301)
  • CURE Childhood Cancer (RO1‐DK098447)
  • University of California, Los Angeles
  • U.S. Department of Veterans Affairs (VA Merit BX002188‐01, VA Merit BX001195‐05)
  • Università di Bologna
  • Fondazione del Monte di Bologna e Ravenna
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
enteroendocrine cells, gut-brain axis, gut-brain signaling, gastrointestinal hormones, enteric neurons, gastrointestinal secretion, gastrointestinal motility, food intake regulation, postprandial blood glucose, sensory signaling
MeSH terms
Brain, Cell Communication, Eating, Gastrointestinal Hormones, Humans, Neural Pathways, Enteroendocrine Cells, Gastrointestinal Tract

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