The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease
Open accessAbstract
Although it is clear that astrocytes and microglia cluster around dense-core amyloid plaques in Alzheimer disease (AD), whether they are primarily attracted to amyloid deposits or are just reacting to plaque-associated neuritic damage remains elusive. We postulate that astrocytes and microglia may differentially respond to fibrillar amyloid β. Therefore, we quantified the size distribution of dense-core thioflavin-S (ThioS)-positive plaques in the temporal neocortex of 40 AD patients and the microglial and astrocyte responses in their vicinity (≤50 μm) and performed correlations between both measures. As expected, both astrocytes and microglia were clearly spatially associated with ThioS-positive plaques (p = 0.0001, ≤50 μm vs. >50 μm from their edge), but their relationship to ThioS-positive plaque size differed: larger ThioS-positive plaques were associated with more surrounding activated microglia (p = 0.0026), but this effect was not observed with reactive astrocytes. Microglial response to dense-core plaques seems to be proportional to their size, which we postulate reflects a chemotactic effect of amyloid β. By contrast, plaque-associated astrocytic response does not correlate with plaque size and seems to parallel the behavior of plaque-associated neuritic damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglial and astrocytic interactions with Aβ amyloid plaques have been associated with amyloid plaque development and neuritic damage [81].”
From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [81]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“One study showed that reactive astrocytes and activated microglia respond differently to Aβ plaque formation; while microglia respond directly to the presence of plaques, astrocytes are associated with neuritic damage that occurs when synapses are already dysfunctional [81].”
From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [81]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These results are consistent with a dynamic phenotypic change of astrocytes from homeostatic to reactive through an intermediate state in response to their microenvironment conditions, namely the presence of Aβ plaques and NFTs23,54–57”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [55]
Experimental — accuracy not yet measuredIn the citing paper
“In the brains of AD patients and APP-overexpressing mice, plaques are surrounded by reactive microglia and astrocytes (Meyer-Luehmann et al., 2008; Serrano-Pozo et al., 2013)”
From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Serrano-Pozo et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345
Self-citationRAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Self-citationSchmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525
Microglia-specific localisation of a novel calcium binding protein, Iba1
Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00040-0 · Cited by 1,476
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
Self-citationMicroglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
Cited by
Sorted by citations
ScaleS: an optical clearing palette for biological imaging
Hama, H., Hioki, H., Namiki, K., Hoshida, T., Kurokawa, H., Ishidate, F., Kaneko, T., Akagi, T., Saito, T., Saido, T. C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4107 · Cited by 600
Wang, C., & Holtzman, D. M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 615
Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease
Kaur, D., Sharma, V., & Deshmukh, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00580-x · Cited by 503
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472
The neuropathology and cerebrovascular mechanisms of dementia
Raz, L., Knoefel, J. E., & Bhaskar, K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.164 · Cited by 512
Astrocytes in human central nervous system diseases: a frontier for new therapies
Verkhratsky, A., Butt, A., Li, B., Illes, P., Zorec, R., Semyanov, A., Tang, Y., & Sofroniew, M. V. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01628-9 · Cited by 428
Microglia-Mediated Synapse Loss in Alzheimer's Disease
Rajendran, L., & Paolicelli, R. C. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1136-17.2017 · Cited by 355
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
Crapser, J. D., Spangenberg, E. E., Barahona, R. A., Arreola, M. A., Hohsfield, L. A., & Green, K. N. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102919 · Cited by 280
ApoE facilitates the microglial response to amyloid plaque pathology
Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171265 · Cited by 297
Deciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282
Self-citationAPOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease
Parhizkar, S., & Holtzman, D. M. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101594 · Cited by 255
Davies, D. S., Ma, J., Jegathees, T., & Goldsbury, C. (2017) · Brain Pathology · doi:10.1111/bpa.12456 · Cited by 251
Astrocyte dysfunction in Alzheimer disease
Acosta, C., Anderson, H. D., & Anderson, C. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24075 · Cited by 262
Luo, W., Liu, W., Hu, X., Hanna, M., Caravaca, A., & Paul, S. M. (2015) · Scientific Reports · doi:10.1038/srep11161 · Cited by 241
Takeda, S., Sato, N., & Morishita, R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00171 · Cited by 236
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gomez‐Arboledas, A., Davila, J. C., Sanchez‐Mejias, E., Navarro, V., Nuñez‐Diaz, C., Sanchez‐Varo, R., Sanchez‐Mico, M. V., Trujillo‐Estrada, L., Fernandez‐Valenzuela, J. J., Vizuete, M., et al. (2018) · Glia · doi:10.1002/glia.23270 · Cited by 220
Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology
Smith, A. M., Davey, K., Tsartsalis, S., Khozoie, C., Fancy, N., Tang, S. S., Liaptsi, E., Weinert, M., McGarry, A., Muirhead, R. C. J., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02372-6 · Cited by 209
“Activated astrocytes and microglia are found around amyloid plaques [52] and genes associated with AD risk are enriched in both cell types, particularly in microglia [12, 56].”
BackgroundFluorescent Diagnostic Probes in Neurodegenerative Diseases
Zhou, J., Jangili, P., Son, S., Ji, M. S., Won, M., & Kim, J. S. (2020) · Advanced Materials · doi:10.1002/adma.202001945 · Cited by 204
Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease
Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 180
Reactive astrocytes in Alzheimer’s disease: A double-edged sword
Chun, H., & Lee, C. J. (2018) · Neuroscience Research · doi:10.1016/j.neures.2017.11.012 · Cited by 176
Astrocytes in Alzheimer's disease: pathological significance and molecular pathways
Preman, P., Alfonso-Triguero, M., Alberdi, E., Verkhratsky, A., & Arranz, A. M. (2021) · Cells · doi:10.3390/cells10030540 · Cited by 176
Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses
(2024) · aging and disease · doi:10.14336/ad.2023.0608 · Cited by 183
Mechanisms of Endogenous Neuroprotective Effects of Astrocytes in Brain Injury
Bylicky, M. A., Mueller, G. P., & Day, R. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6501031 · Cited by 170
Microglia and Astrocyte Function and Communication: What Do We Know in Humans?
Garland, E. F., Hartnell, I. J., & Boche, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824888 · Cited by 165
Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
Jha, M. K., Kim, J.-H., Song, G. J., Lee, W., Lee, I. K., Lee, H., An, S. S. A., Kim, S., & Suk, K. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.12.003 · Cited by 156
Querques, G., Borrelli, E., Sacconi, R., Vitis, L. A. D., Leocani, L., Santangelo, R., Magnani, G., Comı, G., & Bandello, F. M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37271-6 · Cited by 157
Exosome-associated AAV vector as a robust and convenient neuroscience tool
Hudry, E., Martin, C., Gandhi, S., György, B., Scheffer, D. I., Mu, D., Merkel, S. F., Mingozzi, F., Fitzpatrick, Z., Dimant, H., et al. (2016) · Gene Therapy · doi:10.1038/gt.2016.11 · Cited by 146
Self-citationSchöll, M., Carter, S. F., Westman, E., Rodriguez‐Vieitez, E., Almkvist, O., Þórðardóttir, S., Wall, A. E., Graff, C., Långström, B., & Nordberg, A. K. (2015) · Scientific Reports · doi:10.1038/srep16404 · Cited by 153
Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration
Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 155
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Serrano-Pozo, A., Li, H., Li, Z., Muñoz-Castro, C., Jaisa-aad, M., Healey, M. A., Welikovitch, L. A., Jayakumar, R., Bryant, A. G., Noori, A., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01791-4 · Cited by 140
Self-citationTang, J., Huang, L.-F., Deng, J., Wang, Y., Guo, C., Peng, X.-N., Liu, Z., & Gao, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102229 · Cited by 132
Zhao, H., Li, N., Wang, Q.-N., Cheng, X., Li, X. M., & Liu, T. T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.006 · Cited by 130
Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131
Gui, Y., Marks, J. D., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2020) · Brain Pathology · doi:10.1111/bpa.12763 · Cited by 126
Self-citationHypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
March-Diaz, R., Lara-Ureña, N., Romero-Molina, C., Heras-Garvin, A., Ortega-de San Luis, C., Alvarez-Vergara, M. I., Sanchez-Garcia, M. A., Sanchez-Mejias, E., Davila, J. C., Rosales-Nieves, A. E., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00054-2 · Cited by 125
Self-citationCOVID‐19‐related neuropathology and microglial activation in elderly with and without dementia
Poloni, T. E., Medici, V., Moretti, M., Visoná, S. D., Cirrincione, A., Carlos, A. F., Davin, A., Gagliardi, S., Pansarasa, O., Cereda, C., et al. (2021) · Brain Pathology · doi:10.1111/bpa.12997 · Cited by 124
Tzeng, T.-T., Chen, C., Lee, L., Wan-Ping, C., Chung-Kuang, L., Shen, C., Chi-Ying, H. F., Chien-Chih, C., & Shiao, Y. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0266-z · Cited by 127
Neuroinflammation in mouse models of Alzheimer's disease
Saito, T., & Saido, T. C. (2018) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12475 · Cited by 118
Serrano‐Pozo, A., Qian, J., Monsell, S. E., Frosch, M. P., Betensky, R. A., & Hyman, B. T. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000016 · Cited by 106
Self-citationInflammatory Cascade in Alzheimer’s Disease Pathogenesis: A Review of Experimental Findings
de Oliveira, J., Kucharska, E., Garcez, M. L., Rodrigues, M. S., Quevedo, J., Moreno‐González, I., & Budni, J. (2021) · Cells · doi:10.3390/cells10102581 · Cited by 110
Plaque-associated local toxicity increases over the clinical course of Alzheimer disease
Serrano-Pozo, A., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2016) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.10.010 · Cited by 100
Self-citationPlescher, M., Seifert, G., Hansen, J. N., Bedner, P., Steinhäuser, C., & Halle, A. (2018) · Glia · doi:10.1002/glia.23318 · Cited by 108
Long, H., Zhou, Z.-W., Cheng, Y., Luo, H., Li, F., Xu, S., & Gao, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.888989 · Cited by 100
Taylor, X., Cisternas, P., You, Y., You, Y., Xiang, S., Marambio, Y. G., Zhang, J., Vidal, R., & Lasagna‐Reeves, C. A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01900-7 · Cited by 93
Griñán‐Ferré, C., Marsal-García, L., Bellver‐Sanchís, A., Kondengaden, S. M., Turaga, R. C., Vázquez, S., & Pallàs, M. (2019) · Aging · doi:10.18632/aging.102558 · Cited by 85
Walker, L. C. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3025 · Cited by 113
Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65
Hudry, E., Andres-Mateos, E., Lerner, E. P., Volak, A., Cohen, O., Hyman, B. T., Maguire, C. A., & Vandenberghe, L. H. (2018) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2018.07.006 · Cited by 84
Self-citationTzeng, T.-T., Chen, C.-C., Chen, C., Tsay, H.-J., Lee, L., Chen, W.-P., Shen, C.-C., & Shiao, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020598 · Cited by 86
Optical Coherence Tomography Angiography in Neurodegenerative Disorders
Pellegrini, M., Vagge, A., Desideri, L. F., Bernabei, F., Triolo, G., Mastropasqua, R., Noce, C. D., Borrelli, E., Sacconi, R., Iovino, C., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061706 · Cited by 82
Imaging Neuroinflammation in Neurodegenerative Disorders
Masdeu, J. C., Pascual, B., & Fujita, M. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.263200 · Cited by 77
Cheng, H., Shang, Y., Jiang, L., Shi, T., & Wang, L. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1015722 · Cited by 74
Xiong, J., Li, S., Sun, Y., Zhang, X., Dong, Z., Zhong, P., & Sun, X. (2015) · Biology of Sport · doi:10.5604/20831862.1163692 · Cited by 73
Viejo, L., Noori, A., Merrill, E., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12753 · Cited by 69
Self-citationJaisa-aad, M., Muñoz‐Castro, C., Healey, M. A., Hyman, B. T., & Serrano‐Pozo, A. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02712-2 · Cited by 76
Self-citationNaringenin promotes microglial M2 polarization and Aβ degradation enzyme expression
Yang, Z., Kuboyama, T., & Tohda, C. (2019) · Phytotherapy Research · doi:10.1002/ptr.6305 · Cited by 69
Sun, Y., Zeng, X., Liu, Y., Zhan, S., Wu, Z., Zheng, X., & Zhang, X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.090 · Cited by 69
Wang, Q., Wang, Y., Liu, J., Sutphen, C. L., Cruchaga, C., Blazey, T., Gordon, B. A., Su, Y., Chen, C., Shimony, J. S., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101767 · Cited by 63
Chen, C., Bao, Y., Lü, X., Jiang, C., Guo, Y., Tong, S., Zhang, J., Chen, L., & Mao, Y. Q. (2023) · Advanced Science · doi:10.1002/advs.202304025 · Cited by 60
Landlinger, C., Oberleitner, L., Gruber, P., Noiges, B., Yatsyk, K., Santic, R., Mandler, M., & Staffler, G. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0369-6 · Cited by 60
Neuritic Plaques — Gateways to Understanding Alzheimer’s Disease
Tsering, W., & Prokop, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03736-7 · Cited by 59
Furcila, D., Domínguez-Álvaro, M., DeFelipe, J., & Alonso‐Nanclares, L. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00099 · Cited by 57
Nirzhor, S. S. R., Khan, R. I., & Neelotpol, S. (2018) · Biomolecules · doi:10.3390/biom8030093 · Cited by 57
Yazdankhah, M., Shang, P., Ghosh, S., Hose, S., Liu, H., Weiss, J., Fitting, C. S., Bhutto, I. A., Zigler, J. S., Qian, J. X., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100886 · Cited by 57
Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease
Faculty, O. B. O. T. M., Boche, D., Gerhard, A., & Rodriguez-Vieitez, E. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04462-w · Cited by 55
Ohm, D. T., Fought, A. J., Martersteck, A., Coventry, C., Sridhar, J., Gefen, T. D., Weıntraub, S., Bigio, E. H., Mesulam, M. M., Rogalski, E. J., et al. (2020) · Brain Pathology · doi:10.1111/bpa.12902 · Cited by 59
Gao, Y., Liu, Q., Xu, L., Zheng, N., Xiao-ming, H., & Xu, F. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00393-6 · Cited by 54
Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?
Kacířová, M., Zmeškalová, A., Kořínková, L., Železná, B., Kuneš, J., & Maletı́nská, L. (2020) · Clinical Science · doi:10.1042/cs20191313 · Cited by 56
Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease
Haque, M. E., Kim, I., Jakaria, M., Akther, M., & Choi, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00258 · Cited by 55
Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE · doi:10.1371/journal.pone.0118463 · Cited by 52
Matrix metalloproteinase 9–mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy
Zhao, L., Arbel‐Ornath, M., Wang, X., Betensky, R. A., Greenberg, S. M., Frosch, M. P., & Bacskai, B. J. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.016 · Cited by 52
Self-citationVergallo, A., Lista, S., Lemercier, P., Chiesa, P. A., Zetterberg, H., Blennow, K., Potier, M., Habert, M., Baldacci, F., Cavedo, E., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.07.009 · Cited by 50
Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease
Serrano-Pozo, A., Li, Z., Noori, A., Nguyen, H. N., Mezlini, A., Li, L., Hudry, E., Jackson, R. J., Hyman, B. T., & Das, S. (2021) · Nature Aging · doi:10.1038/s43587-021-00123-6 · Cited by 49
Self-citationDas, S., Li, Z., Wachter, A., Alla, S., Noori, A., Abdourahman, A., Tamm, J. A., Woodbury, M. E., Talanian, R. V., Biber, K., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13387 · Cited by 46
Self-citationPhipps, A. J., Vickers, J. C., Taberlay, P. C., & Woodhouse, A. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.05.003 · Cited by 48
NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
Pohlkamp, T., Xian, X., Wong, C. H., Durakoglugil, M. S., Werthmann, G. C., Saido, T. C., Evers, B. M., White, C. L., Connor, J., Hammer, R. E., et al. (2021) · eLife · doi:10.7554/elife.72034 · Cited by 46
Sharman, M. J., Gyengési, E., Liang, H., Chatterjee, P., Karl, T., Li, Q.-X., Wenk, M. R., Halliwell, B. B., Martins, R. N., & Münch, G. W. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.026 · Cited by 46
Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?
Staurenghi, E., Giannelli, S., Testa, G., Sottero, B., Leonarduzzi, G., & Gamba, P. (2021) · Antioxidants · doi:10.3390/antiox10121890 · Cited by 44
Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques
Galea, E., Morrison, W., Hudry, E., Arbel‐Ornath, M., Bacskai, B. J., Gómez‐Isla, T., Stanley, E., & Hyman, B. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516779112 · Cited by 45
Self-citationLiu, P., Reichl, J. H., Rao, E. R., McNellis, B. M., Huang, E. S., Hemmy, L. S., Forster, C. L., Kuskowski, M. A., Borchelt, D., Vassar, R. J., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-161027 · Cited by 41
Astrocytes in depression and Alzheimer’s disease
Liao, Y., Xing, Q., Li, Q., Zhang, J., Pan, R., & Yuan, Z. (2021) · Frontiers of Medicine · doi:10.1007/s11684-021-0875-0 · Cited by 44
Cell-Type-Specific Proteomics: A Neuroscience Perspective
Wilson, R. S., & Nairn, A. C. (2018) · Proteomes · doi:10.3390/proteomes6040051 · Cited by 41
Tajbakhsh, A., Read, M. I., Barreto, G. E., Ávila-Rodriguez, M., Hayat, S. M. G., & Sahebkar, A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173873 · Cited by 41
Muñoz-Castro, C., Noori, A., Magdamo, C. G., Li, Z., Marks, J. D., Frosch, M. P., Das, S., Hyman, B. T., & Serrano-Pozo, A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02383-4 · Cited by 41
Self-citationAfsar, A., Castro, M. D. C. C., Soladogun, A. S., & Li, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087258 · Cited by 45
Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes
Santiago-Balmaseda, A., Aguirre-Orozco, A., Valenzuela-Arzeta, I. E., Villegas-Rojas, M. M., Pérez‐Segura, I., Jiménez-Barrios, N., Hurtado-Robles, E., Rodríguez-Hernández, L. D., Rivera-German, E. R., Guerra‐Crespo, M., et al. (2024) · Cells · doi:10.3390/cells13110921 · Cited by 43
Alzheimer’s disease and sleep disorders: A bidirectional relationship
Chen, J., Peng, G., & Sun, B. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.08.008 · Cited by 45
Palombo, F., Tamagnini, F., Jeynes, J. C. G., Mattana, S., Swift, I. J., Nallala, J., Hancock, J. M., Brown, J. T., Randall, A. D., & Stone, N. (2017) · The Analyst · doi:10.1039/c7an01747b · Cited by 41
Glial epigenetics in neuroinflammation and neurodegeneration
Staszewski, O., & Prinz, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1815-y · Cited by 39
Su, H., Zhang, C., Zou, X. G., Lu, F., Zeng, Y., Guan, H., Ren, Y., Yuan, F., Xu, L., Zhang, M., et al. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112478 · Cited by 39
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice
Sos, K. E., Mayer, M. I., Takács, V. T., Major, A., Bardóczi, Z., Beres, B. M., Szeles, T., Saito, T., Saido, T. C., Mody, I., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0233700 · Cited by 37
Sex-Dependent Effects of Intestinal Microbiome Manipulation in a Mouse Model of Alzheimer’s Disease
Kaur, H., Nookala, S., Singh, S., Mukundan, S., Nagamoto‐Combs, K., & Combs, C. K. (2021) · Cells · doi:10.3390/cells10092370 · Cited by 35
Gene networks and systems biology in Alzheimer's disease: Insights from multi‐omics approaches
Rahimzadeh, N., Srinivasan, S. S., Zhang, J., & Swarup, V. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13790 · Cited by 39
Poppe, L., Rué, L., Timmers, M., Lenaerts, A., Storm, A., Callaerts‐Vegh, Z., Courtand, G., de Boer, A., Smolders, S., Damme, P. V., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0554-4 · Cited by 38
Retinal Biomarkers for Alzheimer Disease: The Facts and the Future
Yuan, A., & Lee, C. S. (2022) · Asia-Pacific Journal of Ophthalmology · doi:10.1097/apo.0000000000000505 · Cited by 39
PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies
Shojaei, M., Schaefer, R., Schlepckow, K., Kunze, L. H., Struebing, F. L., Brunner, B., Willem, M., Bartos, L. M., Feiten, A., Palumbo, G., et al. (2024) · Theranostics · doi:10.7150/thno.97149 · Cited by 35
Su, L., Zhang, R., Chen, Y., Zhu, Z., & Ma, C. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000464119 · Cited by 33
Herr, D., Jew, K., Wong, C., Kennell, A., Gelein, R. M., Chalupa, D., Raab, A., Oberdörster, G., Olschowka, J. A., O’Banion, M. K., et al. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.03.010 · Cited by 34
Exploring the association between interleukin-1β and its interacting proteins in Alzheimer’s disease
Xie, L., Lai, Y., Lei, F., Liu, S., Liu, R., & Wang, T. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3183 · Cited by 33
Werner, C. T., Williams, C. J., Fermelia, M. R., Lin, D., & Li, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01174 · Cited by 32
Daschil, N., Kniewallner, K. M., Obermair, G. J., Hutter‐Paier, B., Windisch, M., Marksteiner, J., & Humpel, C. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.027 · Cited by 32
Metadata
- Authors
- Serrano-Pozo, A., Muzikansky, A., Gómez-Isla, T., Growdon, J. H., Betensky, R. A., Frosch, M. P., & Hyman, B. T.
- Affiliations
- Massachusetts General Hospital (US)
- Harvard University (US)
- Corresponding author
- Hyman, Bradley T.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06
- Volume
- 72
- Issue
- 6
- Pages
- 462-471
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- PMC
- PMC3661683
- OpenAlex
- W1995111570
- Cited by
- 226
- References
- 70
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 21 · 2023: 22 · 2022: 22 · 2021: 25 · 2020: 14 · 2019: 22 · 2018: 20 · 2017: 10 · 2016: 8 · 2015: 16 · 2014: 5 · 2013: 2
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Massachusetts General Hospital
- National Institutes of Health (AG08487)
- National Institute on Aging (AG008487, R01AG008487, P50AG005134, P30AG062421)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid plaques, reactive astrocytes, microglial activation, fibrillar amyloid-beta, plaque size, thioflavin S, temporal neocortex, chemotaxis
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Astrocytes, Brain, Female, Humans, Male, Microglia, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
