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Cited by 176Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Astrocytes in Alzheimer's disease: pathological significance and molecular pathways

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Preman, Pranav, Alfonso-Triguero, Maria, Alberdi, Elena, Verkhratsky, Alexei, Arranz, Amaia M.·2021·Cells
DOI 10.3390/cells10030540PMC PMC7999452

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Abstract

Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease. The advent of transcriptomics technologies enables rapid progress in the characterisation of such pathological astrocyte states. In this review, we provide an overview of the origin, main functions, molecular and morphological features of astrocytes in physiological as well as pathological conditions related to Alzheimer´s disease. We will also explore the main roles of astrocytes in the pathogenesis of Alzheimer´s disease and summarize main transcriptional changes and altered molecular pathways observed in astrocytes during the course of the disease.

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  • Accumulated reactive astrocytes surrounding Aβ plaques form a barrier to limit spreading of pathological Aβ and clear Aβ deposits through phagocytosis, exerting neuroprotective function in Alzheimer's disease.

    “accumulated reactive astrocytes have been commonly observed surrounding Aβ plaques, forming a barrier to limit the spreading of pathological Aβ in the brain parenchyma and clear Aβ deposits through phagocytosis, exerting neuroprotective function in AD (Verkhratsky et al., 2016;Preman et al., 2021;Konishi et al., 2022).”

    From Cell Adhesion Molecule Protocadherin-γC5 Ameliorates Aβ Plaque Pathogenesis by Modulating Astrocyte Function in Alzheimer's Disease (2025) · cites this paper as Preman et al., 2021

    Section 3.1 (page unavailable) reports reactive astrocytes near Aβ plaques, describes a potentially defensive response, and says astrocytes can help clear Aβ and exert neuroprotection. It does not say they form a barrier that limits Aβ spread; its specific example of plaque-associated astrocyte phagocytosis concerns neuritic dystrophies, not Aβ deposits. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Preman, P., Alfonso-Triguero, M., Alberdi, E., Verkhratsky, A., & Arranz, A. M.
Affiliations
  • VIB-KU Leuven Center for Brain & Disease Research (BE)
  • Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain
  • University of the Basque Country (ES)
  • Ikerbasque (ES)
Corresponding author
  • Verkhratsky, Alexei
  • Arranz, Amaia M.
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2021-03-04
Volume
10
Issue
3
Pages
540
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells10030540
PMC
PMC7999452
OpenAlex
W3135516129
Cited by
176
References
33
Citations by year
2026: 31 · 2025: 44 · 2024: 32 · 2023: 32 · 2022: 29 · 2021: 8
FWCI
3.36
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
  • Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Hispana (submittedVersion, cc-by)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • FEDER/Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación (RTI2018-101850-A-I00)
  • IKERBASQUE Basque Foundation of Science (startup2017)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
astrocytes, Alzheimer's disease, neurodegeneration, molecular pathways, astrocyte morphology, pathogenesis, gene expression changes
MeSH terms
Alzheimer Disease, Astrocytes, Humans, Transcriptome

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