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Cited by 60Hepatitis C virus researchHIV, Drug Use, Sexual RiskHIV/AIDS Research and Interventions

Risk factors for HCV acquisition among HIV-positive MSM in Belgium.

Apers, Ludwig, Vanden Berghe, Wim, De Wit, Stéphane, Kabeya, Kabamba, Callens, Steven, Buyze, Jozefien, Kenyon, Christopher, Florence, Eric +1 more·2015·JAIDS Journal of Acquired Immune Deficiency Syndromes
DOI 10.1097/qai.0000000000000528
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Abstract

OBJECTIVE: To better understand risk factors for the sexual transmission of hepatitis C viral (HCV) infection among men who have sex with men (MSM). DESIGN: Case-control study among HIV-infected MSM, attending AIDS Reference Centers in Belgium. METHODS: Cases were HIV-infected MSM who were diagnosed with HCV between January 2010 and December 2013. For each case, 2 controls were randomly selected among the HIV-positive MSM who tested negative for HCV around the same time as the cases were identified. Consenting participants were interviewed with a questionnaire on risk factors. Medical records were abstracted to document past episodes of sexually transmitted infections (STIs). Associations between HCV infection and risk factors were explored using bivariate analysis followed by multiple logistic regression analysis. RESULTS: A total of 52 cases and 90 controls were recruited. In multivariate analysis, douching before anal intercourse [adjusted odds ratio (AOR) = 9.84, 95% CI: 2.26 to 42.78], fisting (AOR = 3.54, 95% CI: 1.31 to 9.57), having intercourse with HIV-positive men (AOR = 5.51, 95% CI: 1.87 to 16.20), and a documented gonorrhoea or chlamydial infection in the year before inclusion in the study (AOR = 4.50, 95% CI: 1.11 to 18.31) were independently associated with incident HCV infection. CONCLUSIONS: Our study confirmed fisting and suffering from other STIs as risk factors for HCV and suggested an increased risk of HCV associated with serosorting. Furthermore, we identified anal douching as being associated with HCV infection. The role that douching plays in the acquisition of HCV infection and other STIs requires further research, as well as the effect of serosorting on STI transmission.

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  • HCV transmission among MSM with HIV infection has been associated with group sex and chemsex.

    “HCV transmission among MSM with HIV infection has also been associated with group sex and chemsex (i.e., using recreational drugs in a sexual context) (1344–1348).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1346]

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Authors
Apers, L., Vanden Berghe, W., De Wit, S., Kabeya, K., Callens, S., Buyze, J., Kenyon, C., Florence, E., & Buvé, A.
Affiliations
  • Ghent University Hospital (BE)
  • Centre Hospitalier Universitaire de Saint-Pierre (BE)
  • Instituut voor Tropische Geneeskunde (BE)
Corresponding author
  • Apers, Ludwig
  • Buyze, Jozefien
  • Kenyon, Christopher
ORCID
Venue
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-04-15
Volume
68
Issue
5
Pages
585-593
ISSN
1525-4135 (ISSN-L)
DOI
10.1097/qai.0000000000000528
OpenAlex
W1974760004
Cited by
60
References
29
Citations by year
2024: 5 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 12 · 2015: 4
FWCI
5.52
Type
journal article
Language
en
Open access
closed
Locations
  • JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
hepatitis C virus, HIV-positive men who have sex with men, sexual transmission, fisting, serosorting, sexually transmitted infections, gonorrhea, chlamydia, risk factors, anal sex
MeSH terms
Adult, Belgium, Hepatitis C, Humans, Interviews as Topic, Therapeutic Irrigation, Male, Middle Aged, Risk Factors, HIV Infections, Case-Control Studies, Homosexuality, Male

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