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Cited by 123Hepatitis C virus researchHIV/AIDS Research and InterventionsHIV, Drug Use, Sexual Risk

Absence of hepatitis C virus transmission in a prospective cohort of heterosexual serodiscordant couples.

Open access
Marincovich, B·2003·Sexually Transmitted Infections
DOI 10.1136/sti.79.2.160PMC PMC1744643
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Abstract

OBJECTIVE: To analyse hepatitis C virus (HCV) transmission in a cohort of heterosexual couples who are discordant both for HIV and for HCV. METHODS: We followed an open cohort of 171 people, 152 women and 19 men, who were not initially infected by either HIV or HCV, and whose steady heterosexual partner presented antibodies to both viruses (index case). Other risk exposures were excluded. Every 6 months clinical, epidemiological, and risk behaviour information was collected, and antibodies to both viruses were determined. RESULTS: During 529 person years of follow up more than 40 000 vaginal or anal penetrations were recorded. 74 partners (43.3%) had vaginal and/or anal intercourse without condoms with the index case; another 15.8%, who always used condoms, declared breaking or slipping episodes during intercourse; and another 22.2% had unprotected orogenital exposures. During the follow up, over 5800 unprotected vaginal and anal contacts with the index case were estimated, as well as more than 25 000 unprotected orogenital contacts. 31 women became pregnant (two were index cases), and seroconversion to HIV occurred for one woman (1.7 per 10 000 unprotected contacts; 95% CI, 0 to 9.5), but there was no seroconversion to HCV (95% CI, 0-6.3 per 10 000 unprotected contacts). CONCLUSION: These results are consistent with a low or null transmissibility of HCV in heterosexual relations, even when the index case is HIV co-infected.

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  • Incident HCV has not been demonstrated to occur among heterosexual couples followed over time.

    “Because incident HCV has not been demonstrated to occur among heterosexual couples followed over time (1334,1371–1373), condom use might not be necessary in such circumstances.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1371]

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Authors
Marincovich, B.
Affiliations
Madrid Health Service (ES)
Corresponding author
Marincovich, B
Venue
Sexually Transmitted Infections
Publisher
BMJ
Published
2003-04-01
Volume
79
Issue
2
Pages
160-162
ISSN
  • 0007-134X (ISSN-L)
  • 1368-4973
DOI
10.1136/sti.79.2.160
PMC
PMC1744643
OpenAlex
W2169264218
Cited by
123
References
18
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 11 · 2012: 11
FWCI
3.48
Type
journal article
Language
en
Open access
Locations
  • Sexually Transmitted Infections (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Abbott Laboratories
  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • Fundación Para La Innovación Y La Prospectiva En Salud En España
  • Merck Sharp and Dohme
  • FP7 International Cooperation
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Keywords
hepatitis C virus, HCV transmission, heterosexual couples, serodiscordant couples, HIV coinfection, unprotected sex, condom use, seroconversion, HIV transmission
MeSH terms
Adolescent, Adult, Female, Follow-Up Studies, Hepatitis C, HIV Seropositivity, Humans, Male, Middle Aged, Prospective Studies, Risk-Taking, Sexual Behavior, Sexual Partners, Cohort Studies, Condoms, Cross-Over Studies, Hepatitis C Antibodies, Heterosexuality

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