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Cited by 28

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype

Thomsen, Gretchen M., Ma, Annie M., Ko, Ara, Harada, Megan Y., Wyss, Livia, Haro, Patricia S., Vit, Jean-Philippe, Shelest, Oksana, Rhee, Peter, Svendsen, Clive N., Ley, Eric J.·2016·Journal of Trauma and Acute Care Surgery
DOI 10.1097/ta.0000000000001248
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Abstract

Background Concussion injury is the most common form of traumatic brain injury (TBI). How recurrent concussions alter long-term outcomes is poorly understood, especially as related to the development of neurodegenerative disease. We evaluated the functional and pathological consequences of repeated TBI over time in wild type (WT) rats as well as rats harboring the human SOD1 mutation ("SOD1"), a model of familial amyotrophic lateral sclerosis (ALS). Methods A total of 42 rats, 26 WT and 16 SOD1, were examined over a study period of 25 weeks (or endpoint). At postnatal day 60, 20 WT and 7 SOD1 rats were exposed to mild, bilateral TBI once per week for either 2 weeks (2×TBI) or 5 weeks (5×TBI) using a controlled cortical impact device. Six WT and nine SOD1 rats underwent sham injury with anesthesia alone. Twenty WT rats were euthanized at 12 weeks after first injury and six WT rats were euthanized at 25 weeks after first injury. SOD1 rats were euthanized when they reached ALS disease endpoint. Weekly body weights and behavioral assessments were performed. Tauopathy in brain tissue was analyzed using immunohistochemistry. Results 2XTBI injured rats initially demonstrated recovery of motor function but failed to recover to baseline within the 12-week study period. Relative to both 2XTBI and sham controls, 5XTBI rats demonstrated significant deficits that persisted over the 12-week period. SOD1 5XTBI rats reached a peak body weight earlier than sham SOD1 rats, indicating earlier o…

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Crossref · 10.1097/ta.0000000000001248

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  • A single focal brain injury did not induce ALS-like signs in a transgenic SOD1 rat model; however, repeated mild bilateral traumatic brain injury accelerated ALS-like signs onset in this model.

    “Supporting the difference between acute and chronic repeated injuries, a single focal brain injury did not induce ALS‐like signs in a transgenic SOD1 rat model 18 ; however, repeated mild bilateral traumatic brain injury accelerated ALS‐like signs onset in this model.”

    From Risk factors for amyotrophic lateral sclerosis: A regional United States case‐control study (2021) · cites this paper as [19]

Citations

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Research works printed but not linked: 33

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Metadata

Authors
Thomsen, G. M., Ma, A. M., Ko, A., Harada, M. Y., Wyss, L., Haro, P. S., Vit, J.-P., Shelest, O., Rhee, P., Svendsen, C. N., & Ley, E. J.
Venue
Journal of Trauma and Acute Care Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-12
Volume
81
Issue
6
Pages
1070-1079
ISSN
2163-0755
DOI
10.1097/ta.0000000000001248
Cited by
28
References
11
Language
en

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