Current understanding of chronic traumatic encephalopathy
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Opinion statement Chronic traumatic encephalopathy (CTE) is a unique neurodegenerative disease found in individuals with a history of repetitive head impacts. The neuropathology of CTE is increasingly well defined. Prospective, longitudinal studies with post-mortem neuropathologic validation as well as in vivo diagnostic techniques are needed in order to advance the understanding of CTE clinically. Given the large number of individuals who incur concussions and other forms of brain trauma, this is an important area for scientific and public health inquiry.
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Chronic traumatic encephalopathy is characterized by accumulation of TAR DNA-binding protein-43 and neurofibrillary tangles of hyperphosphorylated tau beginning perivascularly, and is reported in football, wrestling, boxing, and soccer players, as well as in veterans.
“Chronic traumatic encephalopathy (CTE) is characterized by accumulation of TAR DNA-binding protein-43 (TDP43) and neurofibrillary tangles of hyperphosphorylated tau beginning perivascularly (54), and is reported in football (454, 455), wrestling (455), boxing (325), and soccer (366) players, as well as in veterans (237).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [54]
The prevailing theory of CTE, often expressed in articles as fact, is that it is a distinct and unique neurodegenerative disease.
“In conclusion, the prevailing theory of CTE, often expressed in articles as fact, is that it is a distinct (1, 3, 9-11) and unique (10) neurodegenerative disease (9-13).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [10]
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- Authors
- Baugh, C. M., Robbins, C. A., Stern, R. A., & McKee, A. C.
- Affiliations
- Boston University (US)
- Corresponding author
- Stern, Robert A.
- Venue
- Current Treatment Options in Neurology
- Published
- 2014-07-15
- Volume
- 16
- Issue
- 9
- Pages
- 306-306
- ISSN
- 1092-8480 (ISSN-L)
- 1534-3138
- PMC
- PMC4255271
- OpenAlex
- W1970413515
- Cited by
- 94
- References
- 59
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 17 · 2018: 13 · 2017: 7 · 2016: 13 · 2015: 12
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Treatment Options in Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG013846)
- National Institute of Neurological Disorders and Stroke (U01NS086659)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Keywords
- chronic traumatic encephalopathy, repetitive head impacts, concussion, neurodegenerative diseases, neuropathology, in vivo diagnosis, postmortem neuropathology, traumatic brain injury
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