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Cited by 77Autism Spectrum Disorder ResearchPrenatal Substance Exposure EffectsMaternal Mental Health During Pregnancy and Postpartum

Smoking during Pregnancy and Risk of A utism S pectrum D isorder in a F innish N ational B irth C ohort

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Tran, Phuong Lien, Lehti, Venla, Lampi, Katja M., Helenius, Hans, Suominen, Auli, Gissler, Mika, Brown, Alan S., Sourander, Andre·2013·Paediatric and Perinatal Epidemiology
DOI 10.1111/ppe.12043PMC PMC3652271
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Abstract

Background: Results of previous population‐based studies examining associations between smoking during pregnancy and autism spectrum disorders (ASD) are contradictory. Furthermore, there is a lack of population‐based studies examining the relationship between smoking during pregnancy and the main diagnostic subtypes of ASD. Methods: We conducted a population‐based nested case–control study based on the F innish P renatal S tudy of A utism (FIPS‐A) among liveborn infants delivered in F inland between 1987 and 2005. Data on maternal smoking during pregnancy were available from the F innish M edical B irth R egister (FMBR) since O ctober 1990. Data on ASD in the offspring were obtained from the F innish H ospital D ischarge R egister (FHDR). Results: Among the three subtypes of ASD, maternal smoking during the whole pregnancy was associated with an increased risk of pervasive developmental disorder (PDD) (odds ratio 1.2, 95% confidence interval 1.0, 1.5). The increase in odds persisted after controlling for maternal age, mother's socio‐economic and psychiatric status, and infant's weight for gestational age. However, smoking exposure limited to the first trimester was not associated with PDD or any of the other ASD subtypes. Conclusions: Maternal smoking is related to a modest increase in risk of PDD, while no associations were observed for childhood autism and A sperger's syndrome.

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  • Several studies have reported an association between smoking and increased risk for ASD with intellectual disability, but not without.

    “Several studies have reported an association between smoking and increased risk for ASD with intellectual disability, but not without [143, 144].”

    From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [143]

  • The direction of social class confounding differed by country: in the U.S. and Canada associations were higher after adjustment, whereas in European countries associations were attenuated after adjustment.

    “In the U.S. and Canada, associations were higher after adjusting for sociodemographic variables,52,57 whereas in European countries (Sweden, Finland, and Norway), associations were attenuated after adjustment.51,53,58,59”

    From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [59]

  • Women who continue to smoke when pregnant may be genetically predisposed toward addictive behavior, which may pass along increased genetic loading for neuropathologies related to autism risk, complicating the study of tobacco and neurodevelopment.

    “Women who continue to smoke when pregnant may be genetically predisposed toward addictive behavior, which in turn may pass along increased genetic loading for neuropathologies that are related to autism risk (e.g., through dopamine or serotonin pathways), complicating the study of tobacco and neurodevelopment.”

    From Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence (2014) · cites this paper as [59]

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  1. [26]Langley K Rice F van den Bree MB Thapar A Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review Minerva Pediatrica 2005 57 359 371 16402008

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Authors
Tran, P. L., Lehti, V., Lampi, K. M., Helenius, H., Suominen, A., Gissler, M., Brown, A. S., & Sourander, A.
Affiliations
  • University of Turku (FI)
  • Finnish Institute for Health and Welfare (FI)
  • New York State Psychiatric Institute (US)
  • Department of Biostatistics University of Turku Turku
ORCID
Venue
Paediatric and Perinatal Epidemiology
Publisher
Wiley
Published
2013-04-10
Volume
27
Issue
3
Pages
266-274
ISSN
  • 0269-5022 (ISSN-L)
  • 1365-3016
DOI
10.1111/ppe.12043
PMC
PMC3652271
OpenAlex
W1487045871
Cited by
77
References
38
Citations by year
2026: 5 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 10 · 2013: 2
FWCI
5.10
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Paediatric and Perinatal Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
  • Autism Speaks
  • Tourette Association of America
  • Medical Research Council (MR/K006525/1)
  • National Institute of Mental Health (K02MH065422, 1K02 MH 65422)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
smoking during pregnancy, autism spectrum disorder, pervasive developmental disorders, Asperger syndrome, childhood autism, prenatal tobacco exposure, autism subtypes, birth cohort
MeSH terms
Adolescent, Adult, Child Development Disorders, Pervasive, Female, Finland, Humans, Infant, Maternal Age, Middle Aged, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, Logistic Models, Case-Control Studies, Young Adult

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