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Cited by 78Corneal surgery and disordersElasticity and Material ModelingCorneal Surgery and Treatments

Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution

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Abass, Ahmed, Hayes, Sally, White, Nick, Sorensen, Thomas, Meek, Keith M.·2015·Journal of The Royal Society Interface
DOI 10.1098/rsif.2014.0717PMC PMC4345466
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Abstract

It is thought that corneal surface topography may be stabilized by the angular orientation of out-of plane lamellae that insert into the anterior limiting membrane. In this study, micro-focus X-ray scattering data were used to obtain quantitative information about lamellar inclination (with respect to the corneal surface) and the X-ray scatter intensity throughout the depth of the cornea from the centre to the temporal limbus. The average collagen inclination remained predominantly parallel to the tissue surface at all depths. However, in the central cornea, the spread of inclination angles was greatest in the anterior-most stroma (reflecting the increased lamellar interweaving in this region), and decreased with tissue depth; in the peripheral cornea inclination angles showed less variation throughout the tissue thickness. Inclination angles in the deeper stroma were generally higher in the peripheral cornea, suggesting the presence of more interweaving in the posterior stroma away from the central cornea. An increase in collagen X-ray scatter was identified in a region extending from the sclera anteriorly until about 2 mm from the corneal centre. This could arise from the presence of larger diameter fibrils, probably of scleral origin, which are known to exist in this region. Incorporation of this quantitative information into finite-element models will further improve the accuracy with which they can predict the biomechanical response of the cornea to pathology and refractive procedures.

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  • Stromal interweaving in the peripheral cornea seems to extend to the deeper posterior lamellae.

    “In addition, stromal interweaving in the peripheral cornea seems to extend to the deeper posterior lamellae (Radner et al., 1998, Abass et al., 2015).”

    From Corneal structure and transparency (2015) · cites this paper as Abass et al., 2015

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Cited by

Sorted by citations

Authors
Abass, A., Hayes, S., White, N., Sorensen, T., & Meek, K. M.
Affiliations
  • Cardiff University (GB)
  • Diamond Light Source Ltd, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK
Corresponding author
Meek, Keith M.
ORCID
Venue
Journal of The Royal Society Interface
Publisher
The Royal Society
Published
2015-03
Volume
12
Issue
104
Pages
20140717
ISSN
  • 1742-5662 (ISSN-L)
  • 1742-5689
DOI
10.1098/rsif.2014.0717
PMC
PMC4345466
OpenAlex
W2102640190
Cited by
78
References
1
Citations by year
2026: 7 · 2025: 8 · 2024: 5 · 2023: 14 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 3
FWCI
4.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of The Royal Society Interface (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Diamond Light Source
  • National Institute for Health and Care Research (503626)
  • Medical Research Council (MR/K000837/1, 503626)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
Keywords
corneal collagen, collagen lamellae, lamellar orientation, corneal stroma, corneal biomechanics, finite element model, corneal limbus, corneal thickness
MeSH terms
Aged, Aged, 80 and over, Biomechanical Phenomena, Collagen, Cornea, Female, Humans, Male, Membranes, Artificial, Middle Aged, Radiography, Scattering, Radiation, Sclera, X-Ray Diffraction, X-Rays, Corneal Topography

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