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Cited by 183Corneal surgery and disordersCollagen: Extraction and CharacterizationCorneal Surgery and Treatments

Corneal collagen—its role in maintaining corneal shape and transparency

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Meek, Keith M.·2009·Biophysical Reviews
DOI 10.1007/s12551-009-0011-xPMC PMC5425665
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Abstract

Corneal collagen has a number of properties that allow it to fulfil its role as the main structural component within the tissue. Fibrils are narrow, uniform in diameter and precisely organised. These properties are vital to maintain transparency and to provide the biomechanical prerequisites necessary to sustain shape and provide strength. This review describes the structure and arrangement of corneal collagen from the nanoscopic to the macroscopic level, and how this relates to the maintenance of the form and transparency of the cornea.

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  • Many of these preferred lamellae continue into the sclera and are believed to help the cornea withstand the pull of the extraocular muscles.

    “Many of these appear to continue into the sclera and are believed to help the cornea to withstand the pull of the extraocular muscles [17–19] (Fig. 5 inset).”

    From Structural control of corneal transparency, refractive power and dynamics (2025) · cites this paper as [19]

    The Corneal Lamellae section says vertical and horizontal lamellae may have evolved to withstand forces from the extraocular muscles, supporting the proposed function as a possibility. It describes the cornea integrating with the sclera at the limbus, but does not say that many of those lamellae continue into the sclera. No page numbers are available in our copy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • The preferred orientations at the centre of the cornea may help withstand the pull of the extraocular muscles.

    “The directions at the centre of the cornea may help withstand the pull of the extraocular muscles”

    From Structural control of corneal transparency, refractive power and dynamics (2025) · cites this paper as [19]

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Cited by

Sorted by citations

Authors
Meek, K. M.
Affiliations
Cardiff University (GB)
Corresponding author
Meek, Keith M.
ORCID
Meek, Keith M.
Venue
Biophysical Reviews
Publisher
Springer Science and Business Media LLC
Published
2009-06-06
Volume
1
Issue
2
Pages
83-93
ISSN
  • 1867-2450 (ISSN-L)
  • 1867-2469
DOI
10.1007/s12551-009-0011-x
PMC
PMC5425665
OpenAlex
W2159259628
Cited by
183
References
1
Citations by year
2026: 18 · 2025: 20 · 2024: 21 · 2023: 20 · 2022: 26 · 2021: 22 · 2020: 17 · 2019: 12 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 1
FWCI
0.24
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Biophysical Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Cardiff University
  • European Synchrotron Radiation Facility
  • Medical Research Council
  • Engineering and Physical Sciences Research Council
  • Biotechnology and Biological Sciences Research Council
  • Science and Technology Facilities Council
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
Keywords
corneal collagen, corneal transparency, corneal shape, collagen fibrils, corneal biomechanics, corneal structure

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