Cited by 101Psychosomatic Disorders and Their TreatmentsEmbodied and Extended CognitionNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 329 of the 329 references it cites were found in a registry or an index.

An insula hierarchical network architecture for active interoceptive inference

Open access

Fermin, Alan S. R., Friston, Karl, Yamawaki, Shigeto·2022·Royal Society Open Science

DOI 10.1098/rsos.220226PMC PMC9240682

Open this paper in CoChat — free account

Abstract

In the brain, the insular cortex receives a vast amount of interoceptive information, ascending through deep brain structures, from multiple visceral organs. The unique hierarchical and modular architecture of the insula suggests specialization for processing interoceptive afferents. Yet, the biological significance of the insula's neuroanatomical architecture, in relation to deep brain structures, remains obscure. In this opinion piece, we propose the Insula Hierarchical Modular Adaptive Interoception Control (IMAC) model to suggest that insula modules (granular, dysgranular and agranular), forming parallel networks with the prefrontal cortex and striatum, are specialized to form higher order interoceptive representations. These interoceptive representations are recruited in a context-dependent manner to support habitual, model-based and exploratory control of visceral organs and physiological processes. We discuss how insula interoceptive representations may give rise to conscious feelings that best explain lower order deep brain interoceptive representations, and how the insula may serve to defend the body and mind against pathological depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1098/rsos.220226

Cites

329 of 329 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–329 of 329

Disrupted habenula function in major depression
Lawson, R. P., Nord, C. L., Seymour, B., Thomas, D. L., Dayan, P., Pilling, S., & Roiser, J. P. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.81 · Cited by 210
Estimation of Current and Future Physiological States in Insular Cortex
Livneh, Y., Sugden, A. U., Madara, J. C., Essner, R. A., Flores, V. I., Sugden, L. A., Resch, J. M., Lowell, B. B., & Andermann, M. L. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.027 · Cited by 209
The Feeling of Life Itself: Why Consciousness Is Widespread but Can't Be Computed
Koch, C. (2019) · doi:10.7551/mitpress/11705.001.0001 · Cited by 208
Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 204
Subcortical structural connectivity of insular subregions
Ghaziri, J., Tucholka, A., Girard, G., Boucher, O., Houde, J., Descoteaux, M., Obaïd, S., Gilbert, G., Rouleau, I., & Nguyen, D. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-26995-0 · Cited by 204
Reappraising striatal D1- and D2-neurons in reward and aversion
Soares‐Cunha, C., Coimbra, B., Sousa, N., & Rodrigues, A. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.021 · Cited by 203
Representation of Action Sequence Boundaries by Macaque Prefrontal Cortical Neurons
Fujii, N., & Graybiel, A. M. (2003) · Science · doi:10.1126/science.1086872 · Cited by 199
Operculo-insular pain (parasylvian pain): a distinct central pain syndrome
Garcı́a-Larrea, L., Perchet, C., Créac’h, C., Convers, P., Peyron, R., Laurent, B., Mauguı̀ere, F., & Magnin, M. (2010) · Brain · doi:10.1093/brain/awq220 · Cited by 196
Parallel Cortico-Basal Ganglia Mechanisms for Acquisition and Execution of Visuomotor Sequences—A Computational Approach
Nakahara, H., Doya, K., & Hikosaka, O. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/089892901750363208 · Cited by 195
Neural Correlates of Forward Planning in a Spatial Decision Task in Humans
Simon, D. A., & Daw, N. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4647-10.2011 · Cited by 186
Functional dissociation of stimulus intensity encoding and predictive coding of pain in the insula
Geuter, S., Boll, S., Eippert, F., & Büchel, C. (2017) · eLife · doi:10.7554/elife.24770 · Cited by 184
Habenula Volume in Bipolar Disorder and Major Depressive Disorder: A High-Resolution Magnetic Resonance Imaging Study
Savitz, J. B., Nugent, A. C., Bogers, W., Roiser, J. P., Bain, E., Neumeister, A., Zarate, C. A., Manji, H. K., Cannon, D. M., Marrett, S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.027 · Cited by 182
Insular cortex projection to the nucleus of the solitary tract and brainstem visceromotor regions in the mouse
Shipley, M. T. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90040-5 · Cited by 181
The neural correlates of trait resilience when anticipating and recovering from threat
Waugh, C. E., Wager, T. D., Fredrickson, B. L., Noll, D. C., & Taylor, S. F. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn024 · Cited by 180
Shared Neural Phenotypes for Mood and Anxiety Disorders: A Meta-analysis of 226 Task-Related Functional Imaging Studies
Janiri, D., Moser, D. A., Doucet, G. E., Luber, M. J., Rasgon, A., Lee, W. H., Murrough, J. W., Sani, G., Eickhoff, S. B., & Frangou, S. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3351 · Cited by 173
Predictive Physiological Anticipation Preceding Seemingly Unpredictable Stimuli: A Meta-Analysis
Mossbridge, J., Tressoldi, P. E., & Utts, J. M. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00390 · Cited by 171
Disrupted Dorsal Mid-Insula Activation During Interoception Across Psychiatric Disorders
Nord, C. L., Lawson, R. P., & Dalgleish, T. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20091340 · Cited by 171
The Cerebellum: Brain for an Implicit Self
Walsh, K. S. (2012) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acs054 · Cited by 169
Neural mechanisms resolving exploitation-exploration dilemmas in the medial prefrontal cortex
Domenech, P., Rheims, S., & Koechlin, É. (2020) · Science · doi:10.1126/science.abb0184 · Cited by 169
Subcortical sites mediating sympathetic responses from insular cortex in rats
Cechetto, D. F., & Chen, S. J. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.1.r245 · Cited by 168
Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits
Fossati, P., Hevenor, S. J., Lepage, M., Graham, S. J., Grady, C. L., Keightley, M., Craik, F. I. M., & Mayberg, H. S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.034 · Cited by 167
The neural crossroads of psychiatric illness: an emerging target for brain stimulation
Downar, J., Blumberger, D. M., & Daskalakis, Z. J. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.007 · Cited by 166
Macroanatomy and 3D probabilistic atlas of the human insula
Faillenot, I., Heckemann, R. A., Frot, M., & Hammers, A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.073 · Cited by 162
Distinct illusory own-body perceptions caused by damage to posterior insula and extrastriate cortex.
Heydrich, L., & Blanke, O. (2013) · Brain · doi:10.1093/brain/aws364 · Cited by 161
Two Modulatory Effects of Attention That Mediate Object Categorization in Human Cortex
Rees, G. E., Frackowiak, R. S. J., & Frith, C. (1997) · Science · doi:10.1126/science.275.5301.835 · Cited by 159
Interoception in Psychiatric Disorders: A Review of Randomized, Controlled Trials with Interoception-Based Interventions
Khoury, N. M., Lutz, J. G., & Schuman‐Olivier, Z. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000170 · Cited by 154
Patterns of overlap and segregation between insular cortical, intermediodorsal thalamic and basal amygdaloid afferents in the nucleus accumbens of the rat
Wright, C. I., & Groenewegen, H. J. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00592-7 · Cited by 148
How the insula speaks to the heart: Cardiac responses to insular stimulation in humans
Chouchou, F., Mauguière, F., Vallayer, O., Catenoix, H., Isnard, J., Montavont, A., Jung, J., Pichot, V., Rheims, S., & Mazzola, L. (2019) · Human Brain Mapping · doi:10.1002/hbm.24548 · Cited by 148
Preserved Self-Awareness following Extensive Bilateral Brain Damage to the Insula, Anterior Cingulate, and Medial Prefrontal Cortices
Philippi, C. L., Feinstein, J. S., Khalsa, S. S., Damasio, A., Tranel, D., Landini, G., Williford, K., & Rudrauf, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038413 · Cited by 144
Multiple representations and algorithms for reinforcement learning in the cortico-basal ganglia circuit
Ito, M., & Doya, K. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.001 · Cited by 141
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors
Nieh, E. H., Kim, S., Namburi, P., & Tye, K. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.001 · Cited by 139
Identification of depression subtypes and relevant brain regions using a data-driven approach
Tokuda, T., Yoshimoto, J., Shimizu, Y., Okada, G., Takamura, M., Okamoto, Y., Yamawaki, S., & Doya, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-32521-z · Cited by 136
Self-citation
A volumetric comparison of the insular cortex and its subregions in primates
Bauernfeind, A. L., de Sousa, A. A., Avasthi, T., Dobson, S. D., Raghanti, M. A., Lewandowski, A. H., Zilles, K., Semendeferi, K., Allman, J. M., Craig, A. D. (., et al. (2013) · Journal of Human Evolution · doi:10.1016/j.jhevol.2012.12.003 · Cited by 134
Simulating Emotions: An Active Inference Model of Emotional State Inference and Emotion Concept Learning
Smith, R. S., Parr, T., & Friston, K. J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02844 · Cited by 133
Self-citation
Visceral cortex: Integration of the mucosal senses with limbic information in the rat agranular insular cortex
Krushel, L. A., & van der Kooy, D. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902700105 · Cited by 132
Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex
Hua, L. H., Strigo, I. A., Baxter, L. C., Johnson, S. C., & Craig, A. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00123.2005 · Cited by 132
Physiological Adaptations to Resistance Exercise
Kraemer, W. J., Deschenes, M. R., & Fleck, S. J. (1988) · Sports Medicine · doi:10.2165/00007256-198806040-00006 · Cited by 125
Anterior insula coordinates hierarchical processing of tactile mismatch responses
Allen, M., Fardo, F., Dietz, M. J., Hillebrandt, H. F., Friston, K. J., Rees, G. E., & Roepstorff, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.030 · Cited by 125
Self-citation
The human insula: Architectonic organization and postmortem MRI registration
Morel, A., Gallay, M. N., Baechler, A., Wyss, M., & Gallay, D. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.076 · Cited by 121
Distinct Neural Representation in the Dorsolateral, Dorsomedial, and Ventral Parts of the Striatum during Fixed- and Free-Choice Tasks
Ito, M., & Doya, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1962-14.2015 · Cited by 121
Central Regulation of Autonomic Functions
(2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306637.001.0001 · Cited by 120
The Psychology of Emotion: From Everyday Life to Theory
STRONGMAN, K. T. (2003) · Thammasat University Digital Collections · Cited by 119
Central role for the insular cortex in mediating conditioned responses to anticipatory cues
Kusumoto‐Yoshida, I., Liu, H., Chen, B. T., Fontanini, A., & Bonci, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416573112 · Cited by 119
Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group
Ho, T. C., Gutman, B. A., Pozzi, E., Grabe, H. J., Hosten, N., Wittfeld, K., Völzke, H., Baune, B. T., Dannlowski, U., Förster, K., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.24988 · Cited by 119
What Is Health?
Sterling, P. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/11472.001.0001 · Cited by 118
Post‐rolandic cortical projections of the superior temporal sulcus in the rhesus monkey
Seltzer, B., & Pandya, D. Ν. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903120412 · Cited by 115
Modular architectonic organization of the insula in the macaque monkey
Evrard, H., Logothetis, N., & Craig, A. (2014) · The Journal of comparative neurology · doi:10.1002/cne.23436 · Cited by 113
Dopamine, reward learning, and active inference
FitzGerald, T. H. B., Dolan, R. J., & Friston, K. (2015) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2015.00136 · Cited by 112
Self-citation
Simulating homeostatic, allostatic and goal-directed forms of interoceptive control using active inference
Tschantz, A., Barca, L., Maisto, D., Buckley, C. L., Seth, A. K., & Pezzulo, G. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108266 · Cited by 112
Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat
Ohara, P. T., Granato, A., Moallem, T. M., Wang, B.-R., Tillet, Y., & Jasmin, L. (2003) · Journal of Neurocytology · doi:10.1023/b:neur.0000005598.09647.7f · Cited by 111
Gut focused behavioural treatment (biofeedback) for constipation and faecal incontinence in multiple sclerosis
Wiesel, P. H. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.240 · Cited by 108
Effect of immersion, submersion, and scuba diving on heart rate variability: Figure 1
Schipke, J. D., & Pelzer, M. (2001) · British Journal of Sports Medicine · doi:10.1136/bjsm.35.3.174 · Cited by 106
Structural Connections of Functionally Defined Human Insular Subdivisions
Nomi, J. S., Schettini, E., Broce, I., Dick, A. S., & Uddin, L. Q. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx211 · Cited by 106
Stuttering and anxiety: The difference between stutterers and nonstutterers in verbal apprehension and physiologic arousal during the anticipation of speech and non-speech tasks
Peters, H. F. M., & Hulstijn, W. (1984) · Journal of Fluency Disorders · doi:10.1016/0094-730x(84)90008-1 · Cited by 105
Animal Learning—Visceral and Autonomic Conditioning
Harris, A. H., & Brady, J. V. (1974) · Annual Review of Psychology · doi:10.1146/annurev.ps.25.020174.000543 · Cited by 105
Pain-Related Expectation and Prediction Error Signals in the Anterior Insula Are Not Related to Aversiveness
Fazeli, S., & Büchel, C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-18.2018 · Cited by 105
Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states
Livneh, Y., & Andermann, M. L. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.036 · Cited by 105
Subjective confidence reflects representation of Bayesian probability in cortex
Geurts, L. S., Cooke, J. R. H., van Bergen, R. S., & Jehee, J. F. M. (2022) · Nature Human Behaviour · doi:10.1038/s41562-021-01247-w · Cited by 104
Features of somatosensory manifestations induced by intracranial electrical stimulations of the human insula
Pugnaghi, M., Meletti, S., Castana, L., Francione, S., Nobili, L., Mai, R., & Tassi, L. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.03.013 · Cited by 102
Central afferents to the nucleus of the solitary tract in rats and mice
Gasparini, S., Howland, J. M., Thatcher, A. J., & Geerling, J. C. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24927 · Cited by 101
A common gustatory and interoceptive representation in the human mid-insula
Avery, J. A., Kerr, K. L., Ingeholm, J. E., Burrows, K., Bodurka, J., & Simmons, W. K. (2015) · Human Brain Mapping · doi:10.1002/hbm.22823 · Cited by 99
Consistent Anterior–Posterior Segregation of the Insula During the First 2 Years of Life
Alcauter, S., Lin, W., Smith, J. K., Gilmore, J. H., & Gao, W. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht312 · Cited by 94
Modulation of retrieval processing reflects accuracy of emotional source memoryPreprint
Smith, A. P. R., Henson, R. N., Rugg, M. D., & Dolan, R. J. (2005) · Learning & Memory · doi:10.1101/lm.84305 · Cited by 92
The hierarchical organization of decision making in the primate prefrontal cortex
Sakagami, M., & Tsutsui, K. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00038-3 · Cited by 88
Common and Specific Abnormalities in Cortical Thickness in Patients with Major Depressive and Bipolar Disorders
Niu, M., Wang, Y., Jia, Y., Wang, J., Zhong, S., Lin, J., Sun, Y., Zhao, L., Liu, X., Huang, L., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.010 · Cited by 86
Reward prediction based on stimulus categorization in primate lateral prefrontal cortex
Pan, X., Sawa, K., Tsuda, I., Tsukada, M., & Sakagami, M. (2008) · Nature Neuroscience · doi:10.1038/nn.2128 · Cited by 84
Investigating the relationship between cardiac interoception and autonomic cardiac control using a predictive coding framework
Owens, A. P., Friston, K. J., Low, D. A., Mathias, C. J., & Critchley, H. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.01.001 · Cited by 84
Self-citation
Mirror neuron activity during contagious yawning—an fMRI study
Haker, H., Kawohl, W., Herwig, U., & Wulf Rössler, A. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9189-9 · Cited by 83
Anticipatory stress interferes with utilitarian moral judgment
Starcke, K., Ludwig, A.-C., & Brand, M. (2012) · Judgment and Decision Making · doi:10.1017/s1930297500001832 · Cited by 81
Classical Conditioning of Cardiovascular Responses
Cohen, D. H., & Randall, D. C. (1984) · Annual Review of Physiology · doi:10.1146/annurev.ph.46.030184.001155 · Cited by 80
Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control
Menon, V., Gallardo, G., Pinsk, M. A., Nguyen, V.-D., Li, J., Cai, W., & Wassermann, D. (2020) · eLife · doi:10.7554/elife.53470 · Cited by 79
The impact of somatic symptoms on the course of major depressive disorder
Bekhuis, E., Boschloo, L., Rosmalen, J. G. M., de Boer, M. K., & Schoevers, R. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.06.030 · Cited by 78
A genetically defined insula-brainstem circuit selectively controls motivational vigor
Deng, H., Xiao, X., Yang, T., Ritola, K., Hantman, A., Li, Y., Huang, Z. J., & Li, B. (2021) · Cell · doi:10.1016/j.cell.2021.11.019 · Cited by 75
The organization of insular cortex projections to the amygdaloid central nucleus and autonomic regulatory nuclei of the dorsal medulla
Kapp, B. S., Schwaber, J. S., & Driscoll, P. A. (1985) · Brain Research · doi:10.1016/0006-8993(85)91254-5 · Cited by 74
Polarity of uncertainty representation during exploration and exploitation in ventromedial prefrontal cortex
Trudel, N., Scholl, J., Klein-Flügge, M. C., Fouragnan, E., Tankelevitch, L., Wittmann, M. K., & Rushworth, M. F. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0929-3 · Cited by 74
The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles
Fritz, H.-C., Ray, N. J., Dyrba, M., Sorg, C., Teipel, S. J., & Grothe, M. J. (2018) · Human Brain Mapping · doi:10.1002/hbm.24417 · Cited by 71
Model-based action planning involves cortico-cerebellar and basal ganglia networks
Fermin, A. S. R., Yoshida, T., Yoshimoto, J., Ito, M., Tanaka, S., & Doya, K. (2016) · Scientific Reports · doi:10.1038/srep31378 · Cited by 70
Self-citation
How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation
Hassanpour, M. S., Yan, L., Wang, D. J. J., Lapidus, R. C., Arevian, A. C., Simmons, W. K., Feusner, J. D., & Khalsa, S. S. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0017 · Cited by 70
Physiological and psychological symptoms of grief in widows
Kowalski, S. D., & Bondmass, M. D. (2007) · Research in Nursing & Health · doi:10.1002/nur.20228 · Cited by 69
Effects of acetylcholine in the striatum
Benarroch, E. E. (2012) · Neurology · doi:10.1212/wnl.0b013e31825fe154 · Cited by 67
Electrophysiological and functional connectivity of the human supplementary motor area
Narayana, S., Laird, A. R., Tandon, N., Franklin, C. G., Lancaster, J. L., & Fox, P. T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.060 · Cited by 67
Direct and indirect pathways for choosing objects and actions
Hikosaka, O., Kim, H. F., Amita, H., Yasuda, M., Isoda, M., Tachibana, Y., & Yoshida, A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13876 · Cited by 66
Predicting the unpredictable: critical analysis and practical implications of predictive anticipatory activity
Mossbridge, J., Tressoldi, P. E., Utts, J. M., Ives, J. A., Radin, D. I., & Jonas, W. B. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00146 · Cited by 65
Thoughtful feelings
LeDoux, J. E. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.012 · Cited by 64
Parallel basal ganglia circuits for decision making
Hikosaka, O., Ghazizadeh, A., Griggs, W. S., & Amita, H. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1691-1 · Cited by 63
Bilateral limbic system destruction in man
Feinstein, J. S., Rudrauf, D., Khalsa, S. S., Cassell, M. D., Bruss, J., Grabowski, T. J., & Tranel, D. (2009) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390903066873 · Cited by 62
Mapping the Hierarchical Layout of the Structural Network of the Macaque Prefrontal Cortex
Goulas, A., Uylings, H. B. M., & Stiers, P. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs399 · Cited by 62
The Insula of Reil Revisited: Multiarchitectonic Organization in Macaque Monkeys
Gallay, D., Gallay, M., Jeanmonod, D., Rouiller, E., & Morel, A. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr104 · Cited by 60
The feeling brain: the biology and psychology of emotions
(2015) · Choice Reviews Online · doi:10.5860/choice.192057 · Cited by 58
Habit Learning by Naive Macaques Is Marked by Response Sharpening of Striatal Neurons Representing the Cost and Outcome of Acquired Action Sequences
Desrochers, T. M., Amemori, K., & Graybiel, A. M. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.019 · Cited by 57
Lesion studies of human emotion and feeling
Feinstein, J. S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.007 · Cited by 56
Convergent gustatory and viscerosensory processing in the human dorsal mid‐insula
Avery, J. A., Gotts, S. J., Kerr, K. L., Burrows, K., Ingeholm, J. E., Bodurka, J., Martin, A. D., & Simmons, W. K. (2017) · Human Brain Mapping · doi:10.1002/hbm.23510 · Cited by 56
Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats
Sato, F., Akhter, F., Haque, T., Kato, T., Takeda, R., Nagase, Y., Sessle, B. J., & Yoshida, A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.024 · Cited by 54
An essay on the circulation as behavior
Engel, B. T. (1986) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0002269x · Cited by 52
Pupillary Dynamics Link Spontaneous and Task-Evoked Activations Recorded Directly from Human Insula
Kucyi, A., & Parvizi, J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0435-20.2020 · Cited by 51
Hyperacusis following unilateral damage to the insular cortex: A three-case report
Boucher, O., Turgeon, C., Champoux, S., Ménard, L., Rouleau, I., Lassonde, M. C., Leporé, F., & Nguyen, D. K. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.030 · Cited by 50
Dissociating the Neural Correlates of Experiencing and Imagining Affective Touch
Lucas, M. V., Anderson, L. C., Bolling, D. Z., Pelphrey, K. A., & Kaiser, M. D. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu061 · Cited by 50
Analysis of Heart Rate Variability in Space Medicine
Баевский, Р. М. (2002) · Human Physiology · doi:10.1023/a:1014866501535 · Cited by 49
Cognition, emotion and autonomic responses : the integrative role of the prefrontal cortex and limbic structures
Uylings, H. B. M. (2000) · Medical Entomology and Zoology · Cited by 49
From Pavlov to pain: How predictability affects the anticipation and processing of visceral pain in a fear conditioning paradigm
Labrenz, F., Icenhour, A., Schlamann, M. U., Forsting, M., Bingel, U., & Elsenbruch, S. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.064 · Cited by 48
Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report
Takamura, M., Okamoto, Y., Shibasaki, C., Yoshino, A., Okada, G., Ichikawa, N., & Yamawaki, S. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.080 · Cited by 47
Self-citation
Effects of behavioral activation on default mode network connectivity in subthreshold depression: A preliminary resting-state fMRI study
Yokoyama, S., Okamoto, Y., Takagaki, K., Okada, G., Takamura, M., Mori, A., Shiota, S., Ichikawa, N., Jinnin, R., & Yamawaki, S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.021 · Cited by 44
Self-citation
Functional dissociation within insular cortex: The effect of pre-stimulus anxiety on pain
Lin, C., Hsieh, J., Yeh, T., Lee, S., & Niddam, D. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.035 · Cited by 41
Biofeedback therapy for symptoms of bowel dysfunction following surgery for colorectal cancer
Bartlett, L., Sloots, K., Nowak, M. J., & Ho, Y. H. (2011) · Techniques in Coloproctology · doi:10.1007/s10151-011-0713-5 · Cited by 40
Human operant heart rate conditioning: The importance of individual differences.
McCanne, T. R., & Sandman, C. A. (1976) · Psychological Bulletin · doi:10.1037//0033-2909.83.4.587 · Cited by 39
Heart rate variability in workers of various professions in contrasting seasons of the year
Markov, A., IuG, S., & Bojko, E. R. (2016) · International Journal of Occupational Medicine and Environmental Health · doi:10.13075/ijomeh.1896.00276 · Cited by 39
What is health? Allostasis and the evolution of human design. PeterSterlingCambridge, MA: The MIT Press, 2020
Crews, D. E., & Tuggle, A. (2021) · American Journal of Human Biology · doi:10.1002/ajhb.23698 · Cited by 38
Olszewski and Baxter's cytoarchitecture of the human brainstem
Büttner‐Ennever, J. A., Horn, A. K. E., Olszewski, J., et al. (2014) · KARGER eBooks · Cited by 37
Behavioural Conditioning of Immune Functions: How the Central Nervous System Controls Peripheral Immune Responses by Evoking Associative Learning Processes
Riether, C., Doenlen, R., Pacheco‐López, G., Niemi, M., Engler, A., Engler, H., & Schedlowski, M. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.1.1 · Cited by 37
Cortical projections to the nucleus of the tractus solitarius: An HRP study in the cat
Willett, C. J., Gwyn, D. G., Rutherford, J. G., & Leslie, R. A. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90179-6 · Cited by 37
Primary Interoceptive Cortex Activity during Simulated Experiences of the Body
Wilson‐Mendenhall, C. D., Henriques, A., Barsalou, L. W., & Barrett, L. F. (2018) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01346 · Cited by 37
Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation
Fardo, F., Vinding, M. C., Allen, M., Jensen, T. S., & Finnerup, N. B. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00843.2016 · Cited by 35
Transcranial Direct Current Stimulation of Right Dorsolateral Prefrontal Cortex Does Not Affect Model-Based or Model-Free Reinforcement Learning in Humans
Smittenaar, P., Prichard, G., FitzGerald, T. H. B., Diedrichsen, J., & Dolan, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086850 · Cited by 33
Modality-specific effects of aversive expectancy in the anterior insula and medial prefrontal cortex
Sharvit, G., Corradi‐Dell’Acqua, C., & Vuilleumier, P. O. (2018) · Pain · doi:10.1097/j.pain.0000000000001237 · Cited by 33
Human operant heart rate conditioning: The importance of individual differences.
McCanne, T. R., & Sandman, C. A. (1976) · Psychological Bulletin · doi:10.1037/0033-2909.83.4.587 · Cited by 31
The Physiologic Nature of Sleep
Parmeggiani, P. L., & Velluti, R. A. (2005) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/p388 · Cited by 25
Bayesian modelling captures inter-individual differences in social belief computations in the putamen and insula
Henco, L., Brandi, M., Lahnakoski, J. M., Diaconescu, A. O., Mathys, C. D., & Schilbach, L. (2020) · Cortex · doi:10.1016/j.cortex.2020.02.024 · Cited by 25
Predictive physiological anticipatory activity preceding seemingly unpredictable stimuli: An update of Mossbridge et al’s meta-analysis
Duggan, M., & Tressoldi, P. E. (2018) · F1000Research · doi:10.12688/f1000research.14330.2 · Cited by 22
Empathy to emotional voices and the use of real-time fMRI to enhance activation of the anterior insula
Kanel, D., Al‐Wasity, S., Stefanov, K., & Pollick, F. E. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.021 · Cited by 22
Physiological Psychology: Sleep
Williams, H. L., Holloway, F. A., & Griffiths, W. J. (1973) · Annual Review of Psychology · doi:10.1146/annurev.ps.24.020173.001431 · Cited by 15
Against gustotopic representation in the human brain: there is no Cartesian restaurant
Avery, J. A. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.01.005 · Cited by 15
Heart rate variability and sports
Gavrilova, E. A. (2016) · Human Physiology · doi:10.1134/s036211971605008x · Cited by 14
Hierarchical Control of Behaviour in Human Prefrontal Cortex
Duverne, S., & Koechlin, É. (2017) · Wiley eBooks · doi:10.1002/9781118920497.ch12 · Cited by 14
Cardiovascular psychophysiology: Current issues in response mechanisms biofeedback and methodology
Morley, S. (1977) · Behaviour Research and Therapy · doi:10.1016/0005-7967(77)90030-4 · Cited by 13
Autonomic nerves : basic science, clinical aspects, case studies
Wilson‐Pauwels, L., Stewart, P. A., & Akesson, E. J. (1997) · Cited by 10
Anodal Transcranial Direct Current Stimulation of the Motor Cortex in Healthy Volunteers
Erdoğan, E. T., Saydam, Ş. S., Kurt, A., & Karamürsel, S. (2018) · Neurophysiology · doi:10.1007/s11062-018-9726-2 · Cited by 8
Predictive physiological anticipation preceding seemingly unpredictable stimuli: An update of Mossbridge et al’s meta-analysis
Duggan, M., & Tressoldi, P. E. (2018) · F1000Research · doi:10.12688/f1000research.14330.1 · Cited by 6
Instrumental cardiovascular conditioning: A review
Goldstein, D. S. (1979) · Pavlovian Journal of Biological Science · doi:10.1007/bf03001827 · Cited by 2
Biofeedback and Physiological Patterning in Human Emotion and Consciousness
SCHWARTZ, G. E. R. (1979) · Springer eBooks · doi:10.1007/978-1-4613-2898-8_4 · Cited by 1

Flagged first, then by citations

Research works printed but not linked: 3

Porges SW. 2011 The polyvagal theory: neurophysiological foundations of emotions, attachment, communication, and self-regulation (norton series on interpersonal neurobiology). New York, NY: WW Norton & Company.
Fitts PM, Posner MI. 1967 Human performance. Oxford, England: Brooks/Cole.
Stemmler G. 2004 Physiological processes during emotion. In The regulation of emotion, pp. 48-85. New York, NY: Psychology Press.

Sorted by citations

Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis
Bednarek, L., Harrison, B. J., Davey, C. G., Steward, T., & Jamieson, A. J. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02201-5 · Cited by 1

See all 101

Authors: Fermin, A. S. R., Friston, K., & Yamawaki, S.
Affiliations: Hiroshima University (JP)
Wellcome Centre for Human Neuroimaging (GB)
Corresponding author: Fermin, Alan S. R.
ORCID: Fermin, Alan S. R.
Friston, Karl
Yamawaki, Shigeto
Venue: Royal Society Open Science
Publisher: The Royal Society
Published: 2022-06
Volume: 9
Issue: 6
Pages: 220226-220226
ISSN: 2054-5703 (ISSN-L)
DOI: 10.1098/rsos.220226
PMC: PMC9240682
OpenAlex: W4283707164
Cited by: 101
References: 329
Citations by year: 2026: 31 · 2025: 22 · 2024: 28 · 2023: 16 · 2022: 2
FWCI: 2.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
Locations: Royal Society Open Science (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Centre for Human Neuroimaging (205103/Z/16/Z)
Canada-UK Artificial Intelligence Initiative (ES/T01279X/1)
Japan Agency for Medical Research and Development (JP19dm0107093)
Center of Innovation Program (JPMJCA2208, JPMJCE1311)
Japan Society for the Promotion of Science (20309202, 20K07723, JPMJMS2296)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Embodied and Extended Cognition
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: insula, interoception, prefrontal cortex, striatum, model-based control, depression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An insula hierarchical network architecture for active interoceptive inference

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks