Enhancement of visual cortex plasticity by dark exposure
Open accessAbstract
Dark rearing is known to delay the time course of the critical period for ocular dominance plasticity in the visual cortex. Recent evidence suggests that a period of dark exposure (DE) may enhance or reinstate plasticity even after closure of the critical period, mediated through modification of the excitatory–inhibitory balance and/or removal of structural brakes on plasticity. Here, we investigated the effects of a week of DE on the recovery from a month of monocular deprivation (MD) in the primary visual cortex (V1) of juvenile mice. Optical imaging of intrinsic signals revealed that ocular dominance in V1 of mice that had received DE recovered slightly more quickly than of mice that had not, but the level of recovery after three weeks was similar in both groups. Two-photon calcium imaging showed no significant difference in the recovery of orientation selectivity of excitatory neurons between the two groups. Parvalbumin-positive (PV+) interneurons exhibited a smaller ocular dominance shift during MD but again no differences in subsequent recovery. The percentage of PV+ cells surrounded by perineuronal nets, a structural brake on plasticity, was lower in mice with than those without DE. Overall, DE causes a modest enhancement of mouse visual cortex plasticity. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.
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Sensitivity to LRx is developmentally regulated and includes a refractory period in late adolescence.
“In addition, the sensitivity to LRx is developmentally regulated and includes a refractory period in late adolescence (Huang et al., 2010) which may explain the modest response to DE at some ages (Erchova et al., 2017).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Erchova et al., 2017
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- Authors
- Erchova, I., Vasalauskaite, A., Longo, V., & Sengpiel, F.
- Affiliations
- Cardiff University (GB)
- ORCID (US)
- Corresponding author
- Sengpiel, Frank
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2017-03-05
- Volume
- 372
- Issue
- 1715
- Pages
- 20160159
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC5247591
- OpenAlex
- W2576200020
- Cited by
- 32
- References
- 40
- Citations by year
- 2024: 5 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/J002089/1, BB/M021408/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dark rearing, visual cortex plasticity, ocular dominance, critical period, monocular deprivation, primary visual cortex, parvalbumin interneurons, perineuronal nets, excitation-inhibition balance, orientation selectivity, Hebbian plasticity, homeostatic plasticity, juvenile mice
- MeSH terms
- Animals, Darkness, Female, Interneurons, Male, Neuronal Plasticity, Neurons, Random Allocation, Visual Cortex, Dominance, Ocular, Mice
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