Preliminary Evaluation of the Safety and Probiotic Potential of Akkermansia muciniphila DSM 22959 in Comparison with Lactobacillus rhamnosus GG
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In this study, for the first time, we examined some of the physico-chemical properties of the cell surface of Akkermansia muciniphila DSM 22959, comparing it with those of Lactobacillus rhamnosus GG—one of the most extensively studied probiotic microorganisms. In particular, hydrophobicity, auto-aggregation, co-aggregation, and biofilm formation were investigated. In addition, antibiotic susceptibility, co-culture, and antimicrobial activity of the two strains were compared. Hydrophobicity was evaluated using xylene and toluene, showing that A. muciniphila DSM 22959 possessed moderate hydrophobicity. A. muciniphila showed a faster and higher auto-aggregation ability than Lb. rhamnosus GG, but a lower aptitude in biofilm formation. In the co-aggregation test, the best performance was obtained by Lb. rhamnosus GG. Regarding the susceptibility to antibiotics, the differences between the two strains were remarkable, with A. muciniphila DSM 22959 showing resistance to half of the antibiotic tested. Interesting results were also obtained with regard to the stimulating effect of Lb. rhamnosus GG on the growth of A. muciniphila when co-cultured.
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The percentages of hydrophobicity and auto-aggregation found in this study are higher than those found in other studies with LAB species.
“These percentages of hydrophobicity and auto-aggregation are higher than those found in other studies with LAB species [40,41].”
From Probiotic and Antifungal Attributes of Lactic Acid Bacteria Isolates from Naturally Fermented Brazilian Table Olives (2022) · cites this paper as [40]
Section 3.2 (page not provided) reports that one earlier study found lower hydrophobicity than the value measured here for L. rhamnosus GG, but two others found similar values. Section 3.3 (page not provided) reports that A. muciniphila aggregated more than L. rhamnosus GG, while the latter's aggregation was similar to an earlier result. These limited comparisons do not establish that both percentages in the citing study exceed those found in other studies of LAB species. (LLM, conf=0.82)
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Cites
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
A modified microtiter-plate test for quantification of staphylococcal biofilm formation
Stepanović, S., Vuković, D., Dakić, I., Savić, B., & Švabic-Vlahović, M. (2000) · Journal of Microbiological Methods · doi:10.1016/s0167-7012(00)00122-6 · Cited by 2,570 · see citing works
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works
Guidelines for the evaluation of probiotics in food
Who, F. (2002) · Medical Entomology and Zoology · Cited by 1,843 · see citing works
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058 · see citing works
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · cited 1× · see citing works
“muciniphila has evolved to metabolize the complex glycans provided by the mucus layer as its sole carbon and nitrogen source [6,7].”
BackgroundKos, B., Šušković, J., Vuković, S., Šimpraga, M., Frece, J., & Matošić, S. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.01915.x · Cited by 880 · see citing works
Bacterial adhesion: From mechanism to control
Hori, K., & Matsumoto, S. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.11.014 · Cited by 796 · see citing works
Adhesion, autoaggregation and hydrophobicity of 13 strains of Bifidobacterium longum
Del Re, B., Sgorbati, B., Miglioli, M., & Palenzona, D. (2000) · Letters in Applied Microbiology · doi:10.1046/j.1365-2672.2000.00845.x · Cited by 731 · see citing works
Microbes inside—from diversity to function: the case of Akkermansia
Belzer, C., & de Vos, W. M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.6 · Cited by 715 · see citing works
<i>Akkermansia muciniphila</i> is a promising probiotic
Zhang, T., Li, Q., Cheng, L., Buch, H., & Zhang, F. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13410 · Cited by 708 · see citing works
Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults
Weir, T. L., Manter, D. K., Sheflin, A. M., Barnett, B. A., Heuberger, A. L., & Ryan, E. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070803 · Cited by 642 · see citing works
Adhesion and aggregation properties of probiotic and pathogen strains
Collado, M. C., Meriluoto, J., & Salminen, S. (2008) · European Food Research and Technology · doi:10.1007/s00217-007-0632-x · Cited by 603 · see citing works
Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 582 · see citing works
Towards a better understanding of Lactobacillus rhamnosus GG - host interactions
Segers, M. E., & Lebeer, S. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s7 · Cited by 508 · see citing works
Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?
Geerlings, S. Y., Kostopoulos, I., de Vos, W. M., & Belzer, C. (2018) · Microorganisms · doi:10.3390/microorganisms6030075 · Cited by 452 · see citing works
(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6377 · Cited by 443 · see citing works
van Passel, M. W. J., Kant, R., Zoetendal, E. G., Plugge, C. M., Derrien, M., Malfatti, S., Chain, P., Woyke, T., Palva, A., de Vos, W. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016876 · Cited by 425 · see citing works
Gómez, N. C., Ramiro, J. M. P., Quecán, B. X. V., & Franco, B. D. G. D. M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00863 · Cited by 327 · see citing works
Action and function of Akkermansia muciniphila in microbiome ecology, health and disease
Ottman, N., Geerlings, S. Y., Aalvink, S., de Vos, W. M., & Belzer, C. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.10.001 · Cited by 292 · see citing works
Succi, M., Tremonte, P., Reale, A., Sorrentino, E., Grazia, L., Pacifico, S., & Coppola, R. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.01.037 · Cited by 284 · see citing works
Self-citationCollado, M. C., Laitinen, K., Salminen, S., & Isolauri, E. (2012) · Pediatric Research · doi:10.1038/pr.2012.42 · Cited by 270 · see citing works
Assessment of cell surface properties and adhesion potential of selected probiotic strains
Xu, H., Jeong, H. S., Lee, H. Y., & Ahn, J. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2009.02684.x · Cited by 267 · see citing works
Canani, R. B., Nocerino, R., Terrin, G., Coruzzo, A., Cosenza, L., Leone, L., & Troncone, R. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.004 · Cited by 264 · see citing works
Klare, I., Konstabel, C., Müller-Bertling, S., Reissbrodt, R., Huys, G. R. B., Vancanneyt, M., Swings, J., Goossens, H., & Witte, W. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8982-8986.2005 · Cited by 260 · see citing works
Lebeer, S., Verhoeven, T. L. A., Vélez, M. P., Vanderleyden, J., & Keersmaecker, S. C. J. D. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01393-07 · Cited by 258 · see citing works
Duary, R. K., Rajput, Y. S., Batish, V. K., & Grover, S. (2011) · Indian Journal of Medical Research · doi:10.4103/0971-5916.90992 · Cited by 242 · see citing works
Dubourg, G., Lagier, J., Armougom, F., Robert, C., Audoly, G., Papazian, L., & Raoult, D. (2013) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.10.012 · Cited by 235 · see citing works
Aggregation and adhesion properties of 22 Lactobacillus strains
Tuo, Y., Yu, H., Ai, L., Wu, Z., Guo, B., & Chen, W. (2013) · Journal of Dairy Science · doi:10.3168/jds.2013-6547 · Cited by 229 · see citing works
Brodmann, T., Endo, A., Gueimonde, M., Vinderola, G., Kneifel, W., de Vos, W. M., Salminen, S., & Gómez-Gallego, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01725 · Cited by 191 · see citing works
Guo, X., Li, S., Zhang, J., Wu, F., Li, X., Wu, D., Zhang, M., Ou, Z., Jie, Z., Yan, Q., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-4195-3 · Cited by 177 · see citing works
(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., De Cesare, A., Hilbert, F., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6174 · Cited by 169 · see citing works
Coppola, R., Succi, M., Tremonte, P., Reale, A., Salzano, G., & Sorrentino, E. (2005) · Le Lait · doi:10.1051/lait:2005007 · Cited by 140 · see citing works
Self-citationBotes, M., Loos, B., van Reenen, C. A., & Dicks, L. M. T. (2008) · Archives of Microbiology · doi:10.1007/s00203-008-0408-0 · Cited by 136 · see citing works
Akkermansia muciniphila: a novel functional microbe with probiotic properties
Gómez-Gallego, C., Pohl, S., Salminen, S., de Vos, W. M., & Kneifel, W. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0009 · Cited by 130 · see citing works
Giri, S. S., Sen, S. S., Saha, S., Sukumaran, V., & Park, S. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00473 · Cited by 110 · see citing works
Auto-aggregation and Co-aggregation ability in bifidobacteria and clostridia
Vlková, E., Rada, V., Šmehilová, M., & Killer, J. (2008) · Folia Microbiologica · doi:10.1007/s12223-008-0040-z · Cited by 103 · see citing works
Characterization of vaginal lactobacilli coaggregation ability with Escherichia coli
Ekmekçi, H., Aslım, B., & Öztürk, Ş. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2009.00115.x · Cited by 93 · see citing works
Adhesion, Autoaggregation and Hydrophobicity of Six Lactobacillus Strains
Abdulla, A. A. (2014) · British Microbiology Research Journal · doi:10.9734/bmrj/2014/6462 · Cited by 88 · see citing works
Ferreira, C. L. D. L. F., Grześkowiak, Ł., Collado, M. C., & Salminen, S. (2011) · Journal of Food Protection · doi:10.4315/0362-028x.jfp-11-074 · Cited by 78 · see citing works
(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Fernández Escámez, P. S., Girones, R., Koutsoumanis, K., Lindqvist, R., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5315 · Cited by 72 · see citing works
Probiotic Attributes of Autochthonous Lactobacillus rhamnosus Strains of Human Origin
Pithva, S. P., Shekh, S. L., Dave, J. M., & Vyas, B. R. M. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-0839-9 · Cited by 69 · see citing works
Intestinal Mucus Barrier in Normal and Inflamed Colon
Corazziari, E. S. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181a117ea · Cited by 48 · see citing works
Succi, M., Tremonte, P., Pannella, G., Tipaldi, L., Cozzolino, A., Romaniello, R., Sorrentino, E., & Coppola, R. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01067 · Cited by 43 · see citing works
Self-citationFong, F. L. Y., Kirjavainen, P. V., Wong, V. H. Y., & El-Nezami, H. S. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.040 · Cited by 42 · see citing works
Ruíz, L., Sánchez, B., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & Margollés, A. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.05.014 · Cited by 38 · see citing works
Santarmaki, V., Kourkoutas, Y., Ζουμποπούλου, Γ., Mavrogonatou, E., Kiourtzidis, M., Chorianopoulos, N., Tassou, C. C., Tsakalidou, E., Simopoulos, C. E., & Ypsilantis, P. (2017) · Current Microbiology · doi:10.1007/s00284-017-1285-z · Cited by 35 · see citing works
Tremonte, P., Pannella, G., Succi, M., Tipaldi, L., Sturchio, M., Coppola, R., Luongo, D., & Sorrentino, E. (2017) · Archivio Istituzionale della Ricerca - Università degli Studi del Molise · Cited by 34 · see citing works
Self-citationMicrobial Diversity in Ecosystem Sustainability and Biotechnological Applications
(2019) · Springer eBooks · doi:10.1007/978-981-13-8315-1 · Cited by 34 · see citing works
Antimicrobial Effect of Malpighia Punicifolia and Extension of Water Buffalo Steak Shelf‐Life
Tremonte, P., Sorrentino, E., Succi, M., Tipaldi, L., Pannella, G., Ibáñez, E., Mendiola, J. A., Renzo, T. D., Reale, A., & Coppola, R. (2015) · Journal of Food Science · doi:10.1111/1750-3841.13141 · Cited by 29 · see citing works
Self-citationPreservation by freezing of potentially probiotic strains ofLactobacillus rhamnosus
Succi, M., Tremonte, P., Reale, A., Sorrentino, E., & Coppola, R. (2007) · Annals of Microbiology · doi:10.1007/bf03175352 · Cited by 21 · see citing works
Self-citationSucci, M., Sorrentino, E., Renzo, T. D., Tremonte, P., Reale, A., Tipaldi, L., Pannella, G., Russo, A., & Coppola, R. (2014) · Journal of Pharmacy and Nutrition Sciences · doi:10.6000/1927-5951.2014.04.01.10 · Cited by 10 · see citing works
Self-citationSánchez, B., Burns, P., Ruíz, L., Binetti, A. G., Vinderola, G., Reinheimer, J. A., Margollés, A., Ruas‐Madiedo, P., & Reyes‐Gavilán, C. G. D. L. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.026 · Cited by 6 · see citing works
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- [18]Gorbach S. Doron S. Magro F. Lactobacillus rhamnosus GG. The microbiota in gastrointestinal pathophysiology: implications for human health, prebiotics, probiotics, and dysbiosis Floch M.H. Ringel Y. Walker W.A. Academic Press Salt Lake City, UT, USA 2017 chapter 7 79 88
Cited by
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Raftar, S. K. A., Ashrafian, F., Yadegar, A., Lari, A., Moradi, H. R., Shahryari, A., Azimirad, M., Alavifard, H., Mohsenifar, Z., Davari, M., et al. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00484-21 · Cited by 166 · see citing works
Luo, Y., Lan, C., Li, H., Ouyang, Q., Kong, F., Wu, A., Ren, Z., Tian, G., Cai, J., Yu, B., et al. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00338-4 · Cited by 127 · see citing works
Barzegar, H., Alizadeh Behbahani, B., & Falah, F. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2365 · Cited by 108 · see citing works
Sadeghi, M., Panahi, B., Mazlumi, A., Hejazi, M. A., Komi, D. E. A., & Nami, Y. (2022) · LWT · doi:10.1016/j.lwt.2022.113471 · Cited by 92 · see citing works
Commensal Obligate Anaerobic Bacteria and Health: Production, Storage, and Delivery Strategies
Andrade, J. C., Almeida, D., Domingos, M., Seabra, C. L., Machado, D., Freitas, A. C., & Gomes, A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00550 · Cited by 77 · see citing works
Toxicological safety evaluation of pasteurized Akkermansia muciniphila
Druart, C., Plovier, H., Hul, M. V., Brient, A., Phipps, K. R., de Vos, W. M., & Cani, P. D. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.4044 · Cited by 69 · see citing works
Rodríguez‐Sánchez, S., Fernández‐Pacheco, P., Seseña, S., Pintado, C., & Palop, M. L. (2021) · LWT · doi:10.1016/j.lwt.2021.111142 · Cited by 66 · see citing works
Iorizzo, M., Lombardi, S. J., Ganassi, S., Testa, B., Ianiro, M., Letizia, F., Succi, M., Tremonte, P., Vergalito, F., Cozzolino, A., et al. (2020) · Antibiotics · doi:10.3390/antibiotics9050262 · Cited by 57 · see citing works
Self-citationZhang, C., Ma, K., Nie, K., Deng, M., Luo, W., Wu, X., Huang, Y., & Wang, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.973046 · Cited by 60 · see citing works
Rahmati‐Joneidabad, M., Behbahani, B. A., Taki, M., Hesarinejad, M. A., & Toker, Ö. S. (2024) · LWT · doi:10.1016/j.lwt.2024.116636 · Cited by 53 · see citing works
Wu, W.-G., Zhao, Z., Zhao, Z., Zhang, D., Zhang, Q., Zhang, J., Fang, Z., Bai, Y., & Guo, X. (2023) · Nutrients · doi:10.3390/nu15234901 · Cited by 47 · see citing works
Iorizzo, M., Testa, B., Lombardi, S. J., Ganassi, S., Ianiro, M., Letizia, F., Succi, M., Tremonte, P., Vergalito, F., Cozzolino, A., et al. (2020) · Antibiotics · doi:10.3390/antibiotics9080442 · Cited by 46 · see citing works
Self-citationAli, M. S., Lee, E., Lim, S., Suk, K., & Park, S. (2023) · Antioxidants · doi:10.3390/antiox12020238 · Cited by 43 · see citing works
Li, L., Li, M., Chen, Y., Yu, Z., Chen, P., Yu, Z., Cheng, W., Zhang, W., Wang, Z., Gao, X., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1354447 · Cited by 42 · see citing works
Barta, G., Cornea‐Cipcigan, M., Mărgăoan, R., & Vodnar, D. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.871896 · Cited by 39 · see citing works
Abbasi, A., Bazzaz, S., da Cruz, A. G., Khorshidian, N., Saadat, Y. R., Sabahi, S., Ozma, M. A., Lahouty, M., Aslani, R., & Mortazavian, A. M. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10118-x · Cited by 37 · see citing works
Iorizzo, M., Ganassi, S., Albanese, G., Letizia, F., Testa, B., Tedino, C., Petrarca, S., Mutinelli, F., Mazzeo, A., & Cristofaro, A. D. (2022) · Veterinary Sciences · doi:10.3390/vetsci9050236 · Cited by 36 · see citing works
Self-citationProbiotic Potentials of Lactic Acid Bacteria and Yeasts from Raw Goat Milk in Nigeria
Akinyemi, M. O., Ogunremi, O. R., Adeleke, R. A., & Ezekiel, C. N. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-10022-w · Cited by 37 · see citing works
In vitro investigation on lactic acid bacteria isolatedfrom Yak faeces for potential probiotics
Zhang, Q., Wang, M., Ma, X., Li, Z., Jiang, C., Pan, Y., & Zeng, Q. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.984537 · Cited by 38 · see citing works
Meradji, M., Bachtarzi, N., Mora, D., & Kharroub, K. (2023) · Foods · doi:10.3390/foods12122312 · Cited by 33 · see citing works
Natural Aggregation of Lactobacillus: Mechanisms and Influencing Factors
Wang, S., Li, L., Yu, L., Tian, F., Zhao, J., Zhai, Q., & Chen, W. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105007 · Cited by 34 · see citing works
Hou, F., Tang, J., Liu, Y., Tan, Y., Wang, Y., Zheng, L., Liang, D., Lin, Y., Wang, L., Pan, Z., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03361-22 · Cited by 30 · see citing works
Gu, H.-Y., Fan, J., Bao, P., Qu, W., Hu, Z., Qi, B., Zhang, X., & Yu, A. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311015 · Cited by 27 · see citing works
Iorizzo, M., Testa, B., Ganassi, S., Lombardi, S. J., Ianiro, M., Letizia, F., Succi, M., Tremonte, P., Vergalito, F., Cozzolino, A., et al. (2021) · Journal of Fungi · doi:10.3390/jof7050379 · Cited by 27 · see citing works
Self-citationMachado, D., Barbosa, J. C., Almeida, D., Andrade, J. C., Freitas, A. C., & Gomes, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159152 · Cited by 26 · see citing works
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Filardi, R., Gargari, G., Mora, D., & Arioli, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-23980-6 · Cited by 26 · see citing works
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Ma, X., Tian, M., Yu, X., Liu, M., Li, B., Ren, D., & Wang, W. (2024) · Foods · doi:10.3390/foods13030442 · Cited by 25 · see citing works
Mei, L., Wang, J., Hao, Y., Zeng, X., Yang, Y., Wu, Z., & Ji, Y. S. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2416481 · Cited by 26 · see citing works
Simões, L., Fernandes, N., de Souza, A., dos Santos, L., Magnani, M., Abrunhosa, L., Teixeira, J., Schwan, R. F., & Dias, D. R. (2022) · Fermentation · doi:10.3390/fermentation8060277 · Cited by 23 · see citing works
Lei, W., Hao, L., You, S., Yao, H., Liu, C., & Zhou, H. (2022) · LWT · doi:10.1016/j.lwt.2022.113917 · Cited by 24 · see citing works
Truong, A., Kang, J. E., Yoo, M.-S., Nguyen, T. T., Youn, S.-Y., Yoon, S., & Cho, Y. S. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02902-0 · Cited by 26 · see citing works
Prete, R., Long, S. L., Joyce, S. A., & Corsetti, A. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa076 · Cited by 22 · see citing works
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Nami, Y., Panahi, B., Jalaly, H. M., Rostampour, M., & Hejazi, M. A. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10234-2 · Cited by 16 · see citing works
Wu, P., Xue, J., Zhu, Z., Yao, Y., Sun, Q., Xie, M., Wang, B., Huang, P., Feng, Z., & Zhao, J. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13241 · Cited by 13 · see citing works
Tang, S., Xu, C., Zhou, Y., Shen, Y., Zeng, Q., & Su, D. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c07429 · Cited by 13 · see citing works
Lv, N., Wang, C., Zhou, H., Ma, X., Yu, X., & Ren, D. (2024) · Foods · doi:10.3390/foods13131979 · Cited by 12 · see citing works
Urcan, A. C., Criste, A. D., Bobiş, O., Cornea‐Cipcigan, M., Giurgiu, A.-I., & Dezmirean, D. S. (2024) · Microorganisms · doi:10.3390/microorganisms12061249 · Cited by 12 · see citing works
Vergalito, F., Bagnoli, D., Maiuro, L., Pannella, G., Palombo, V., Testa, B., Coppola, F., Marco, R. M. A. D., Tremonte, P., Lombardi, S. J., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1462220 · Cited by 13 · see citing works
Self-citationTian, M., Wang, H., Li, Y., Wang, J., Ren, D., & Lin, K. (2025) · Food Research International · doi:10.1016/j.foodres.2025.115748 · Cited by 11 · see citing works
Tang, Z., Qian, Y., Li, Y., Wang, R., & Liu, Z. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112462 · Cited by 10 · see citing works
Evolving Technologies in Gastrointestinal Microbiome Era and Their Potential Clinical Applications
Ajayi, A., Jolaiya, T. F., & Smith, S. I. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082565 · Cited by 10 · see citing works
Moussaoui, T., Khali, M., & Madi, N. (2021) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-021-00943-5 · Cited by 9 · see citing works
Deswal, G., Selwal, M. K., Nirvan, H., & Selwal, K. K. (2022) · International Microbiology · doi:10.1007/s10123-022-00312-2 · Cited by 9 · see citing works
Alp, D. (2022) · Journal of Basic Microbiology · doi:10.1002/jobm.202100590 · Cited by 8 · see citing works
Liu, B., Tomtong, P., Charoensiddhi, S., & Vongsangnak, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144910 · Cited by 8 · see citing works
Albanese, G., Giurgiu, A.-I., Urcan, A. C., Paşca, C., TERNAR, T. N., Bonta, V., Criscio, D. D., Iorizzo, M., Cristofaro, A. D., & Dezmirean, D. S. (2026) · Microorganisms · doi:10.3390/microorganisms14030579 · Cited by 4 · see citing works
Self-citationda Rosa, C. E., Pinilla, C. M. B., Toss, L. D., & Brandelli, A. (2025) · Foods · doi:10.3390/foods14132334 · Cited by 4 · see citing works
Ye, M., Jiang, Y., Han, Q., Li, X., Meng, C., Ji, C., Ji, F., & Zhou, B. (2025) · Veterinary Sciences · doi:10.3390/vetsci12020165 · Cited by 4 · see citing works
Reyes-Castillo, P. A., Esquivel-Campos, A. L., Torres-Maravilla, E., Zúñiga-León, E., Mendoza‐Pérez, F., González-Vázquez, R., Córdova-Espinoza, M. G., Gutiérrez‐Nava, M. A., González-Vázquez, R., & Mayorga-Reyes, L. (2025) · Life · doi:10.3390/life15050804 · Cited by 3 · see citing works
Wang, X., Li, Q., Lai, W., Xie, A., Zhang, M., Hu, K., Li, J., Li, Q., Zhao, N., Ao, X., et al. (2025) · International Dairy Journal · doi:10.1016/j.idairyj.2025.106400 · Cited by 4 · see citing works
Huang, B., Xian, Y., Xue, W., Pu, Z., Kong, P., Li, P., Zhao, Y., Tai, L., Chen, Z., Lan, Z., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1627870 · Cited by 3 · see citing works
Zhou, X., Ou, Y., Li, N., & Long, X. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107273 · Cited by 3 · see citing works
Fonseca, M., Vedor, R., Barbosa, J. C., Gomes, A., & Machado, D. (2024) · LWT · doi:10.1016/j.lwt.2024.116187 · Cited by 3 · see citing works
Fakruddin, M., Karim, M. A. B., Islam, B. U., Safa, A., Jime, J. S., Bulbul, N., & Shishir, M. A. (2024) · Current Genomics · doi:10.2174/0113892029317403240815044408 · Cited by 3 · see citing works
Molecular characterization of extended-spectrum β-lactamases from the Akkermansia genus
Lin, J., Wang, T., Zhou, Y., Sha, J., Chen, X., Wang, W., Zhang, C., Xie, F., Chu, Y., Wang, X., et al. (2024) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2024.110998 · Cited by 3 · see citing works
Evaluating Effects of Antibiotics Across Preclinical Models of the Human Gastrointestinal Microbiota
Auchtung, T. A., Lerma, A. I., Schuchart, K., & Auchtung, J. M. (2025) · MicrobiologyOpen · doi:10.1002/mbo3.70030 · Cited by 3 · see citing works
Deng, Y., Wang, Y., Liu, Y., Yang, X., Zhang, H., Xue, X., & Wan, Y. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12441 · Cited by 3 · see citing works
Zamojska, D., Rosicka‐Kaczmarek, J., Macierzyńska-Piotrowska, E., & Nowak, A. (2025) · Microorganisms · doi:10.3390/microorganisms13020317 · Cited by 2 · see citing works
Liu, Q., Jian, Y., Li, G., Zhu, L., Ren, H., Wang, S., Lu, H., Zhang, T., Zeng, W., & Wang, L. (2025) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2025.111406 · Cited by 2 · see citing works
Kurnosov, A. S., Linde, N. N., Molodtsova, P. A., Glazunova, E. V., Moskalenko, A. M., Sheptulina, A. F., Бодунова, Н. А., & Zlobovskaya, O. A. (2025) · Molecular Biology · doi:10.1134/s0026893325700517 · Cited by 2 · see citing works
Akkermansia muciniphila – obiecujący kandydat na probiotyk nowej generacji
Markowska, E., & Kiersztan, A. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.2478/ahem-2021-0036 · Cited by 2 · see citing works
Deciphering mucin degrading ability and safety aspects of enterococcus strain from human feces
Deswal, G., Nirvan, H., Selwal, M. K., & Selwal, K. K. (2024) · Biologia · doi:10.1007/s11756-024-01603-x · Cited by 2 · see citing works
Atlama, K., Şengün, İ. Y., & Nalbantsoy, A. (2024) · Biologia · doi:10.1007/s11756-024-01842-y · Cited by 2 · see citing works
Yu, J., An, N., Duan, Z., Li, J., & Zhang, L. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107352 · Cited by 2 · see citing works
You, X., Song, S., Li, B., Wang, H., Zhang, L., Li, X., Chen, J., Zhu, Z., & Zhao, G. (2025) · Microorganisms · doi:10.3390/microorganisms13061323 · Cited by 1 · see citing works
Hu, D., Yan, J., Li, Y., Wu, J., Xie, Y., Peng, L., Zhang, E., Jiang, H., Sun, Q., & Chu, X. (2026) · Microorganisms · doi:10.3390/microorganisms14020381 · Cited by 1 · see citing works
Paul, S., Banerjee, S., Banerjee, S., & Goel, G. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-10941-y · Cited by 1 · see citing works
Hou, X., Feng, J., Qin, J., Mo, J., Rong, Y., Lv, J., Li, S., Tian, J., Cheng, Y., & Han, B. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10689-x · Cited by 1 · see citing works
Microbiomes in Medicine and Agriculture
ROSENBERG, E. B. (2021) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-65317-0_10 · Cited by 1 · see citing works
Wu, P. S., Xue, J., Zhu, Z., Yu, Y., Sun, Q., Xie, M., Wang, B., Huang, P., Feng, Z., & Zhao, J. (2024) · Preprints.org · doi:10.20944/preprints202401.0241.v1 · Cited by 1 · see citing works
Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genusPreprint
Lin, J., Wang, T., Zhou, Y., Sha, J., Chen, X., Wang, W., Zhang, C., Xie, F., Chu, Y., Wang, X., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.598323 · Cited by 1 · see citing works
Champiri, I. D., Bamzadeh, Z., Rahimi, E., & Rouhi, L. (2023) · Iranian Journal of Medical Microbiology · doi:10.30699/ijmm.17.6.669
Detection of Biofilm Formation
Nataraj, B. H., & Mallappa, R. H. (2025) · Methods and protocols in food science · doi:10.1007/978-1-0716-4758-5_7
Akkermansia Muciniphila is Associated with Human Health: What Should we Know?
Ostrowski, B., & Krawczyk, B. (2025) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2025-0011
Truong, A.-T., Kang, J. E., Yoo, M.-S., Nguyen, T. T., Youn, S.-Y., Yoon, S.-S., & Cho, Y. S. (2024) · Figshare · doi:10.6084/m9.figshare.26591492
Xu, C., Lei, L., Huang, G., Zhou, Y., Shen, Y., Zeng, Q., & Su, D. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.10.031
Kang, Z., Chen, Y., Ding, C., Zhu, F., Yan, Z., Wang, S., & Song, C. (2025) · Surfaces and Interfaces · doi:10.1016/j.surfin.2025.108346
Zhou, C., Zou, M., Liu, M., Zhai, H., Pan, Z., Wu, Q., Ding, Y., & Wang, J. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108173
Maji, S., Biswas, P., AGRAWAL, S., SHIT, S., & Dey, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.26.708187
Sultana, S., Deka, H., Choudhury, A., Mahanti, K., Ganguly, D., Ghosh, D., & Chakraborty, A. (2026) · Journal of Natural Remedies · doi:10.18311/jnr/2026/54268
Zidi, G., Hamma-Faradji, S., Barache, N., Ait-meddour, A., Ouarabi, L., Zeghbib, W., Boudjouan, F., Spano, G., & Drider, D. (2026) · Brazilian Journal of Microbiology · doi:10.1007/s42770-026-01946-4
Das, M., Biswas, P., Ghosh, R., Nandi, A., Biswas, R., Kar, T. K., Chattopadhyay, S., & Dam, S. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11211-7
- Authors
- Cozzolino, A., Vergalito, F., Tremonte, P., Iorizzo, M., Lombardi, S. J., Sorrentino, E., Luongo, D., Coppola, R., Di Marco, R., & Succi, M.
- Affiliations
- University of Molise (IT)
- Institute of Biostructure and Bioimaging (IT)
- Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Via De Sanctis, 86100 Campobasso, Italy
- Corresponding author
- Sorrentino, Elena
- ORCID
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2020-01-30
- Volume
- 8
- Issue
- 2
- Pages
- 189
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC7074805
- OpenAlex
- W3003710691
- Cited by
- 84
- References
- 54
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 20 · 2023: 11 · 2022: 13 · 2021: 7 · 2020: 6
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Akkermansia muciniphila, Lactobacillus rhamnosus GG, probiotic safety, cell surface hydrophobicity, self-aggregation, co-aggregation, biofilm formation, antibiotic susceptibility, antimicrobial activity, co-culture, strain comparison
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