SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

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Cell entry mechanisms of SARS-CoV-2

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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19)

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Membrane Binding Proteins of Coronaviruses

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Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage sitePreprint

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A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?

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SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tractsPreprint

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D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect

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D936Y and Other Mutations in the Fusion Core of the SARS-Cov-2 Spike Protein Heptad Repeat 1 Undermine the Post-Fusion AssemblyPreprint

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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

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The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

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COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus

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Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

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In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic

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Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication

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A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

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Measuring infectious SARS-CoV-2 in clinical samples reveals a higher viral titer:RNA ratio for Delta and Epsilon vs. Alpha variants

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SARS-CoV-2 variants reveal features critical for replication in primary human cells

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Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

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Virus-like Particles: Measures and Biological Functions

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Advancing lung organoids for COVID-19 research

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In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters

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SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity

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SARS-CoV-2 Spike Furin Cleavage Site and S2′ Basic Residues Modulate the Entry Process in a Host Cell-Dependent Manner

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The basic reproductive number and particle-to-plaque ratio: comparison of these two parameters of viral infectivity

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Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve In Vitro to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage

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Comparison of SARS-CoV-2 Antibody Responses and Seroconversion in COVID-19 Patients Using Twelve Commercial Immunoassays

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Propagation of SARS-CoV-2 in Calu-3 Cells to Eliminate Mutations in the Furin Cleavage Site of Spike

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Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

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Machine learning-driven SERS fingerprinting of disintegrated viral components for rapid detection of SARS-CoV-2 in environmental dust

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Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants

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Modeling within-host and aerosol dynamics of SARS-CoV-2: The relationship with infectiousness

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Viral detection and identification in 20 min by rapid single-particle fluorescence in-situ hybridization of viral RNA

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Site-Specific Glycosylation Patterns of the SARS-CoV-2 Spike Protein Derived From Recombinant Protein and Viral WA1 and D614G Strains

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Improved Neutralisation of the SARS-CoV-2 Omicron Variant following a Booster Dose of Pfizer-BioNTech (BNT162b2) COVID-19 Vaccine

Basile, K., Rockett, R. J., McPhie, K. A., Fennell, M., Johnson-Mackinnon, J. C., Agius, J. E., Fong, W., Rahman, H., Ko, D., Donavan, L., et al. (2022) · Viruses · doi:10.3390/v14092023 · Cited by 30 · see citing works

Transmission and Protection against Reinfection in the Ferret Model with the SARS-CoV-2 USA-WA1/2020 Reference Isolate

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Variable Performance in 6 Commercial SARS-CoV-2 Antibody Assays May Affect Convalescent Plasma and Seroprevalence Screening

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Modeling Within-Host Dynamics of SARS-CoV-2 Infection: A Case Study in Ferrets

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Decontamination of SARS-CoV-2 from cold-chain food packaging provides no marginal benefit in risk reduction to food workers

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The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation

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Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

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Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

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A Combination of Membrane Filtration and Raman-Active DNA Ligand Greatly Enhances Sensitivity of SERS-Based Aptasensors for Influenza A Virus

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SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia

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Aptamer-coated track-etched membranes with a nanostructured silver layer for single virus detection in biological fluids

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Systematic Exploration of SARS-CoV-2 Adaptation to Vero E6, Vero E6/TMPRSS2, and Calu-3 Cells

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Improved neutralisation of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech (BNT162b2) COVID-19 vaccine boosting with a third dosePreprint

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Neutralization of SARS-CoV-2 Variants by rVSV-ΔG-Spike-Elicited Human Sera

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Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera

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Multiplex Lithographic SERS Aptasensor for Detection of Several Respiratory Viruses in One Pot

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Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2Preprint

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The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia

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Isolation of ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats

Guo, H., Li, A., Dong, T.-Y., Si, H.-R., Hu, B., Li, B., Zhu, Y., Shi, Z., & Letko, M. C. (2023) · Journal of Virology · doi:10.1128/jvi.00395-23 · Cited by 21 · see citing works

A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells

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Comparison among plaque assay, tissue culture infectious dose (TCID ) and real-time RT-PCR for SARS-CoV-2 variants quantification

Zapata-Cardona, M. I., Flórez‐Álvarez, L., Gómez-Gallego, D. M., Moncada-Díaz, M. J., Hernández, J. C., Díaz, F. J., Rugeles, M. T., Aguilar-Jiménez, W., & Zapata, W. (2022) · Iranian Journal of Microbiology · doi:10.18502/ijm.v14i3.9758 · Cited by 21 · see citing works

Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling

Frolova, E. I., Palchevska, O., Lukash, T., Domínguez, F. D. B. P., Britt, W. J., & Frolov, I. V. (2022) · Journal of Virology · doi:10.1128/jvi.00753-22 · Cited by 18 · see citing works

Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy

Toelzer, C., Gupta, K., Berger, I., & Schaffitzel, C. (2023) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798323000049 · Cited by 16 · see citing works

Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovinesPreprint

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Know your enemy and know yourself – the case of SARS-CoV-2 host factors

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Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model

Cochin, M., Touret, F., Driouich, J., Moureau, G., Petit, P.-R., Laprie, C., Solas, C., de Lamballerie, X. N., & Nougaırède, A. (2021) · Antiviral Research · doi:10.1016/j.antiviral.2021.105212 · Cited by 16 · see citing works

The Reassessed Potential of SARS-CoV-2 Attenuation for COVID-19 Vaccine Development—A Systematic Review

Goławski, M., Lewandowski, P., Jabłońska, I., & Delijewski, M. (2022) · Viruses · doi:10.3390/v14050991 · Cited by 16 · see citing works

Human models for COVID‐19 research

Woodall, M. N. J., Masonou, T., Case, K., & Smith, C. M. (2021) · The Journal of Physiology · doi:10.1113/jp281499 · Cited by 13 · see citing works

A non-transmissible live attenuated SARS-CoV-2 vaccine

Adler, J. M., Vidal, R. M., Voß, A., Kunder, S., Nascimento, M., Abdelgawad, A., Langner, C., Vladimirova, D., Osterrieder, N., Gruber, A. D., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.05.004 · Cited by 15 · see citing works

Evaluation of Residual Infectivity after SARS-CoV-2 Aerosol Transmission in a Controlled Laboratory Setting

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Efficient in vitro assay for evaluating drug efficacy and synergy against emerging SARS-CoV-2 strains

Woodall, M. N. J., Ellis, S., Zhang, S., Kembou-Ringert, J. E., Kite, K., Buggiotti, L., Jacobs, A. I., Agyeman, A. A., Masonou, T., Palor, M., et al. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01233-24 · Cited by 13 · see citing works

Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics

Wu, M., Zhang, Y., Grosser, M., Tipper, S., Venter, D. J., Lin, H., & Jie Lu, B. (2021) · Frontiers in Research Metrics and Analytics · doi:10.3389/frma.2021.683212 · Cited by 14 · see citing works

Immune durability and protection against SARS-CoV-2 re-infection in Syrian hamsters

Field, C. J., Heinly, T. A., Patel, D., Sim, D. G., Luley, E., Gupta, S. L., Vanderford, T. H., Wrammert, J., & Sutton, T. C. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2058419 · Cited by 13 · see citing works

SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise

Duerr, R., Crosse, K. M., Valero-Jimenez, A. M., & Dittmann, M. (2021) · Microorganisms · doi:10.3390/microorganisms9071389 · Cited by 12 · see citing works

Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell Lines

Bamford, C., Broadbent, L., Aranday-Cortés, E., McCabe, M., McKenna, J. P., Courtney, D., Touzelet, O., Ali, A., Roberts, G. C., López–Campos, G., et al. (2022) · Viruses · doi:10.3390/v14020325 · Cited by 12 · see citing works

Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7Preprint

Lamers, M. M., Breugem, T. I., Mykytyn, A. Z., Wang, Y., Gröen, N., Knoops, K., Schipper, D., van der Vaart, J., Koopman, C. D., Zhang, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.03.441080 · Cited by 11 · see citing works

Single domain antibodies derived from ancient animals as broadly neutralizing agents for SARS-CoV-2 and other coronaviruses

Lim, H., Kok, B.-H., Lim, C., Majeed, A. A. A., Leow, C., & Leow, C. (2022) · Biomedical Engineering Advances · doi:10.1016/j.bea.2022.100054 · Cited by 10 · see citing works

Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants

Gilliland, T. H., Dunn, M., Liu, Y., Alcorn, M. D. H., Terada, Y., Vasilatos, S. N., Lundy, J. D., Li, R., Nambulli, S., Larson, D. P., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107764 · Cited by 10 · see citing works

Targeting spike glycans to inhibit SARS-CoV2 viral entry

Guseman, A. J., Rennick, L. J., Nambulli, S., Roy, C. N., Martinez, D. R., Yang, D. T., Bhinderwala, F., Vergara, S. V., Schaefer, A., Baric, R. S., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2301518120 · Cited by 10 · see citing works

Glycosaminoglycan binding by arboviruses: a cautionary tale

Alcorn, M. D. H., & Klimstra, W. B. (2022) · Journal of General Virology · doi:10.1099/jgv.0.001726 · Cited by 10 · see citing works

Detection of the ORF1 Gene Is an Indicator of the Possible Isolation of Severe Acute Respiratory Syndrome Coronavirus 2

Shirato, K., Kakizaki, M., Tomita, Y., Kawase, M., & Takeda, M. (2022) · Pathogens · doi:10.3390/pathogens11030302 · Cited by 10 · see citing works

Nanoisland SERS-Substrates for Specific Detection and Quantification of Influenza A Virus

Zhdanov, G. A., Gambaryan, A. S., Ахметова, А. И., Yaminsky, I. V., Kukushkin, V. I., & Zavyalova, E. G. (2023) · Biosensors · doi:10.3390/bios14010020 · Cited by 9 · see citing works

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Johnson, B. A., Xie, X., Bailey, A. L., Kalveram, B., Lokugamage, K. G., Muruato, A., Zou, J., Zhang, X., Juelich, T., Smith, J. K., et al. (2021) · Nature · doi:10.1038/s41586-021-03237-4 · Cited by 694 · see citing works

Furin Cleavage Site Is Key to SARS-CoV-2 PathogenesisPreprint

Johnson, B. A., Xie, X., Kalveram, B., Lokugamage, K. G., Muruato, A. E., Zou, J., Zhang, X., Juelich, T. L., Smith, J. K., Zhang, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.26.268854 · Cited by 186 · see citing works

A Deletion Encompassing the Furin Cleavage Site in the Spike Encoding Gene Does Not Alter SARS-CoV-2 Replication in Lung Tissues of Mink and Neutralization by Convalescent Human Serum Samples

Valleriani, F., Jurišić, L., Pancrazio, C. D., Irelli, R., Ciarrocchi, E., Martino, M., Cocco, A., Felice, E. D., Colaianni, M. L., Decaro, N., et al. (2022) · Pathogens · doi:10.3390/pathogens11101152 · Cited by 5 · see citing works

Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage

Minami, S., Kotaki, T., Sakai, Y., Okamura, S., Torii, S., Ono, C., Motooka, D., Hamajima, R., Nouda, R., Nurdin, J. A., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.02859-23 · Cited by 10 · see citing works

SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity

Sasaki, M., Toba, S., Itakura, Y., Chambaro, H. M., Kishimoto, M., Tabata, K., Intaruck, K., Uemura, K., Sanaki, T., Sato, A., et al. (2021) · mBio · doi:10.1128/mbio.01415-21 · Cited by 44 · see citing works