The DOI matches its Crossref record; 193 of the 194 references it cites were found in a registry or an index.
Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications
Open accessAbstract
Human milk is a rich source of nutrients and energy, shaped by mammalian evolution to provide all the nutritive requirements of the newborn. In addition, several molecules in breast milk act as bioactive agents, playing an important role in infant protection and guiding a proper development. While major breast milk nutrients such as lactose, lipids and proteins are readily digested and consumed by the infant, other molecules, such as human milk oligosaccharides and glycosylated proteins and lipids, can escape intestinal digestion and transit through the gastrointestinal tract. In this environment, these molecules guide the composition of the developing infant intestinal microbiota by preventing the colonization of enteric pathogens and providing carbon and nitrogen sources for other colonic commensals. Only a few bacteria, in particular Bifidobacterium species, can gain access to the energetic content of milk as it is displayed in the colon, probably contributing to their predominance in the intestinal microbiota in the first year of life. Bifidobacteria deploy exquisite molecular mechanisms to utilize human milk oligosaccharides, and recent evidence indicates that their activities also target other human milk glycoconjugates. Here, we review advances in our understanding of how these microbes have been shaped by breast milk components and the strategies associated with their consumption of milk glycoconjugates.
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“Infants fed formula supplemented with Bimuno-galactooligosaccharide (B-GOS®; Bimuno™, Clasado Biosciences Ltd, Buckinghamshire, UK), a proprietary product containing at least 65% GOS, had increased abundance of Bifidobacterium and Lactobacillus compared to unsupplemented infants, similar to levels reported in breastfed infants (Garrido et al., 2013;Vandenplas et al., 2014).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Garrido et al., 2013
In the citing paper
“However, B. infantis is able to produce extracellular glycosidases that allow it to cleave and consume these glycan moieties [45, 92].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [92]
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Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Breastfeeding and the Use of Human Milk
Breastfeeding, S. O. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2491 · Cited by 5,357
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Breastfeeding and the use of human milk
BREASTFEEDING, S. O., Eidelman, A. I., Schanler, R. J., Johnston, M., Landers, S., Noble, L., Szucs, K., & Viehmann, L. (2012) · Pediatrics · doi:10.1542/peds.2011-3552 · Cited by 4,357
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Wiederschain, G. Y. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909090156 · Cited by 4,089
Research works printed but not linked: 4
- Moro, 1905, Morphologische und biologische Untersuchung über die Darmbakterien des Säuglings, Jahrb f Kinderh, 61, 687
- Polonowski, 1931, Sur deux nouveaux sucres du lait de femme, le gynolactose et l’allolactose, C R Acad Sci, 192, 1319
- Sela, 2010, Metabolism of bifidobacteria, 45
- Stanley, 2009, N-Glycans
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut Bifidobacteria Populations in Human Health and Aging
Arboleya, S., Watkins, C., Stanton, C., & Ross, R. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01204 · Cited by 701
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490
Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut
Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015) · Pediatric Research · doi:10.1038/pr.2014.156 · Cited by 439
Metadata
- Authors
- Garrido, D., Dallas, D. C., & Mills, D. A.
- Affiliations
- University of California, Davis (US)
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2013-04-01
- Volume
- 159
- Issue
- Pt_4
- Pages
- 649-664
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- PMC
- PMC4083661
- OpenAlex
- W2147201779
- Cited by
- 228
- References
- 194
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 22 · 2021: 20 · 2020: 28 · 2019: 20 · 2018: 18 · 2017: 24 · 2016: 15 · 2015: 25 · 2014: 16 · 2013: 4
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- California Dairy Research Foundation
- National Institutes of Health
- University of California, Davis
- National Center for Complementary and Integrative Health (R01AT007079, R21AT006180)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065122, R01HD061923, R01HD059127)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- human milk oligosaccharides, Bifidobacterium, glycosylated proteins, colonic fermentation, infant gut colonization, bioactive milk components
- MeSH terms
- Bifidobacterium, Female, Glycoconjugates, Humans, Infant, Infant, Newborn, Milk, Human, Gastrointestinal Tract
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