Cited by 228Infant Nutrition and HealthGut microbiota and healthProbiotics and Fermented Foods

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Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications

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Garrido, Daniel, Dallas, David C., Mills, David A.·2013·Microbiology

DOI 10.1099/mic.0.064113-0PMC PMC4083661

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Abstract

Human milk is a rich source of nutrients and energy, shaped by mammalian evolution to provide all the nutritive requirements of the newborn. In addition, several molecules in breast milk act as bioactive agents, playing an important role in infant protection and guiding a proper development. While major breast milk nutrients such as lactose, lipids and proteins are readily digested and consumed by the infant, other molecules, such as human milk oligosaccharides and glycosylated proteins and lipids, can escape intestinal digestion and transit through the gastrointestinal tract. In this environment, these molecules guide the composition of the developing infant intestinal microbiota by preventing the colonization of enteric pathogens and providing carbon and nitrogen sources for other colonic commensals. Only a few bacteria, in particular Bifidobacterium species, can gain access to the energetic content of milk as it is displayed in the colon, probably contributing to their predominance in the intestinal microbiota in the first year of life. Bifidobacteria deploy exquisite molecular mechanisms to utilize human milk oligosaccharides, and recent evidence indicates that their activities also target other human milk glycoconjugates. Here, we review advances in our understanding of how these microbes have been shaped by breast milk components and the strategies associated with their consumption of milk glycoconjugates.

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See all 228

Authors: Garrido, D., Dallas, D. C., & Mills, D. A.
Affiliations: University of California, Davis (US)
ORCID: Garrido, Daniel
Dallas, David C.
Mills, David A.
Venue: Microbiology
Publisher: Microbiology Society
Published: 2013-04-01
Volume: 159
Issue: Pt_4
Pages: 649-664
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/mic.0.064113-0
PMC: PMC4083661
OpenAlex: W2147201779
Cited by: 228
References: 194
Citations by year: 2026: 3 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 22 · 2021: 20 · 2020: 28 · 2019: 20 · 2018: 18 · 2017: 24 · 2016: 15 · 2015: 25 · 2014: 16 · 2013: 4
FWCI: 2.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Bill and Melinda Gates Foundation
California Dairy Research Foundation
National Institutes of Health
University of California, Davis
National Center for Complementary and Integrative Health (R01AT007079, R21AT006180)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065122, R01HD061923, R01HD059127)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: human milk oligosaccharides, Bifidobacterium, glycosylated proteins, colonic fermentation, infant gut colonization, bioactive milk components
MeSH terms: Bifidobacterium, Female, Glycoconjugates, Humans, Infant, Infant, Newborn, Milk, Human, Gastrointestinal Tract

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Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications

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