Synergistic effects of resistance training and protein intake: Practical aspects

Guimarães-Ferreira, Lucas; Cholewa, Jason Michael; Naimo, Marshall Alan; Zhi, X.I.A.; Magagnin, Daiane; Dal Ponte de Sá, Rafaele Bis; Streck, Emilio Luiz; da Silva Teixeira, Tamiris; Zanchi, Nelo Eidy

doi:10.1016/j.nut.2013.12.017

Cited by 34Muscle metabolism and nutritionMuscle Physiology and DisordersSports Performance and Training

Synergistic effects of resistance training and protein intake: Practical aspects

Guimarães-Ferreira, Lucas, Cholewa, Jason Michael, Naimo, Marshall Alan, Zhi, X.I.A., Magagnin, Daiane, Dal Ponte de Sá, Rafaele Bis, Streck, Emilio Luiz, da Silva Teixeira, Tamiris +1 more·2014·Nutrition

DOI 10.1016/j.nut.2013.12.017

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Abstract

Resistance training is a potent stimulus to increase skeletal muscle mass. The muscle protein accretion process depends on a robust synergistic action between protein intake and overload. The intake of protein after resistance training increases plasma amino acids, which results in the activation of signaling molecules leading to increased muscle protein synthesis (MPS) and muscle hypertrophy. Although both essential and non-essential amino acids are necessary for hypertrophy, the intake of free L-leucine or high-leucine whole proteins has been specifically shown to increase the initiation of translation that is essential for elevated MPS. The literature supports the use of protein intake following resistance-training sessions to enhance MPS; however, less understood are the effects of different protein sources and timing protocols on MPS. The sum of the adaptions from each individual training session is essential to muscle hypertrophy, and thus highlights the importance of an optimal supplementation protocol. The aim of this review is to present recent findings reported in the literature and to discuss the practical application of these results. In that light, new speculations and questions will arise that may direct future investigations. The information and recommendations generated in this review should be of benefit to clinical dietitians as well as those engaged in sports.

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Protein supplementation in combination with resistance-type muscle strengthening exercise is an efficient intervention for lean mass and strength gain in elderly individuals.
“PS in combination with resistance-type MSE has been identified as an efficient intervention for LM and strength gain in elderly individuals [11,13,15,19,59,64].”
From The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials (2019) · cites this paper as [64]

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Authors: Guimarães-Ferreira, L., Cholewa, J. M., Naimo, M. A., Zhi, X. I. A., Magagnin, D., Dal Ponte de Sá, R. B., Streck, E. L., da Silva Teixeira, T., & Zanchi, N. E.
Affiliations: Coastal Carolina University (US)
West Virginia University (US)
Jinggangshan University (CN)
Universidade do Extremo Sul Catarinense (BR)
Corresponding author: Zanchi, Nelo Eidy
ORCID: Cholewa, Jason Michael
Streck, Emilio Luiz
Zanchi, Nelo Eidy
Venue: Nutrition
Publisher: Elsevier BV
Published: 2014-10
Volume: 30
Issue: 10
Pages: 1097-1103
ISSN: 0899-9007 (ISSN-L)
DOI: 10.1016/j.nut.2013.12.017
OpenAlex: W2066848214
Semantic Scholar: 979ce221ef2636f81b1bc9d996aaba7a57ddedda
Cited by: 34
References: 65
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 2
FWCI: 0.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: resistance training, protein intake, muscle protein synthesis, muscle hypertrophy, skeletal muscle mass, leucine, amino acid supplementation, protein timing, protein sources, translation initiation, plasma amino acids, dietary supplementation
MeSH terms: Dietary Proteins, Humans, Hypertrophy, Leucine, Muscle Proteins, Protein Biosynthesis, Exercise, Muscle, Skeletal, Dietary Supplements, Resistance Training

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Synergistic effects of resistance training and protein intake: Practical aspects

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