Cited by 571Bone Metabolism and DiseasesSignaling Pathways in DiseaseNuclear Receptors and Signaling

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Regulation of NFATc1 in Osteoclast Differentiation

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Kim, Jung Ha, Kim, Nacksung·2014·Journal of Bone Metabolism

DOI 10.11005/jbm.2014.21.4.233PMC PMC4255043

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Abstract

Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL). Activation of transcription factors such as microphthalmia transcription factor (MITF), c-Fos, NF-κB, and nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation. In particular, NFATc1 plays the role of a master transcription regulator of osteoclast differentiation. To date, several mechanisms, including transcription, methylation, ubiquitination, acetylation, and non-coding RNAs, have been shown to regulate expression and activation of NFATc1. In this review, we have summarized the various mechanisms that control NFATc1 regulation during osteoclast differentiation.

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THE EXPRESSION OF NFATC1 IS MORE PREDOMINANT IN TRIPLE NEGATIVE BREAST CARCINOMA PATIENTS
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Peer Review #1 of "Undercarboxylated osteocalcin inhibits the early differentiation of osteoclast mediated by Gprc6a (v0.2)"
(2021) · PeerJ · doi:10.7287/peerj.10898v0.2/reviews/1
Peer Review #2 of "Undercarboxylated osteocalcin inhibits the early differentiation of osteoclast mediated by Gprc6a (v0.1)"
(2021) · PeerJ · doi:10.7287/peerj.10898v0.1/reviews/2

Authors: Kim, J. H., & Kim, N.
Affiliations: Chonnam National University (KR)
Corresponding author: Kim, Nacksung
ORCID: Kim, Jung Ha
Kim, Nacksung
Venue: Journal of Bone Metabolism
Publisher: Korean Society for Bone and Mineral Research
Published: 2014
Volume: 21
Issue: 4
Pages: 233
ISSN: 2287-6375 (ISSN-L)
2287-7029
DOI: 10.11005/jbm.2014.21.4.233
PMC: PMC4255043
OpenAlex: W2132541910
Cited by: 570
References: 69
Citations by year: 2026: 54 · 2025: 43 · 2024: 54 · 2023: 64 · 2022: 58 · 2021: 57 · 2020: 68 · 2019: 51 · 2018: 46 · 2017: 31 · 2016: 26 · 2015: 17
FWCI: 2.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (tdm)
Locations: Journal of Bone Metabolism (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: NFATc1, osteoclastogenesis, transcriptional regulation, epigenetic regulation, DNA methylation, ubiquitination, acetylation, non-coding RNA, macrophage colony-stimulating factor, RANKL, MITF, c-fos, NF-κB, bone resorption

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Regulation of NFATc1 in Osteoclast Differentiation

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