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Regulation of NFATc1 in Osteoclast Differentiation
Open accessAbstract
Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL). Activation of transcription factors such as microphthalmia transcription factor (MITF), c-Fos, NF-κB, and nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation. In particular, NFATc1 plays the role of a master transcription regulator of osteoclast differentiation. To date, several mechanisms, including transcription, methylation, ubiquitination, acetylation, and non-coding RNAs, have been shown to regulate expression and activation of NFATc1. In this review, we have summarized the various mechanisms that control NFATc1 regulation during osteoclast differentiation.
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“NFATc1 binds to its own promoter, switching on an epigenetically controlled autoregulatory cycle that permits efficient induction of the osteoclast-specific genes, tartrate-resistant acid phosphatase (TRAP), cathepsin K, as well as the fusion-specific genes, dendritic cell-specific transmembrane protein (DC-STAMP) and ATPase H+ transporting V0 subunit D2 (ATP6v0d2) [20,25,26] (Figure 3).”
From Osteoclasts and Microgravity (2020) · cites this paper as [20]
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“In RANKL-activated HSCs, polyubiquitination of NIK is inhibited [18], and TRAF6 activates a cascade of kinases, including extracellular regulated kinase (ERK), p38 mitogen-activated protein kinase (p38), c-jun N-terminal kinase (JNK), phosphatidylinositol-3 kinase (PI3K), and Akt and IkB kinases [20,21].”
From Osteoclasts and Microgravity (2020) · cites this paper as [20]
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“This cascade requires Lys63-linked TRAF-6 auto-ubiquitination [22] and initiates the transcription of activator protein-1 (AP-1), c-Fos, NF-κB, and nuclear factor of activated T cells cytoplasmic calcineurin-dependent 1 (NFATc1), the master regulator of osteoclast differentiation [20,23,24].”
From Osteoclasts and Microgravity (2020) · cites this paper as [20]
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“Among genes harboring an excess of HF SNCs associated with specific facial features, we find RUNX2, EDAR, and GLI3133, NFATC1134, SPOP135, DDR2136 and NELL1137, possibly carrying changes in regulatory regions”
From A catalog of single nucleotide changes distinguishing modern humans from archaic hominins (2019) · cites this paper as [134]
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“…such as tartrate-resistant acid phosphatase (TRAP), cathepsin K, dendritic cell-specific transmembrane protein (DC-STAMP), and osteoclast-associated receptor (OSCAR), which are essential to osteoclast differentiation and function (Kim and Kim, 2014; Kim et al., 2005; 2008; Walsh et al., 2006).”
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“NFATc1 orchestrates a signaling cascade that stimulates activator protein 1 and costimulatory signal– mediated intracellular Ca(2)+ oscillation (24,26,27).”
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Lin, L., Wang, H., Guo, W., He, E., Huang, K., & Zhao, Q. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109935 · Cited by 29
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“…of osteo-clast differentiation, regulates several osteoclast-targeting genes such as cathepsin K (Ctsk), tartrate-resistant acid phosphatase (Trap), calcitonin receptor (Ctr), osteoclast-associated receptor (Oscar), and matrix metalloproteinase-9 (MMP-9), through cooperation with c-Fos [19–21].”
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“Another previous study suggested that NFATc1 is a common target gene of the essential transcription factors NF‐κB and AP‐1/c‐Fos (J. H. Kim & Kim, 2014).”
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“Receptor activator of nuclear factor (NF)-κB ligand (RANKL) is a key cytokine inducing osteoclast differentiation that activates NF-κB and mitogen-activated protein kinase (MAPK) signaling pathway components including inhibitor of κB (IκB), p38, extracellular signal-regulated kinase (ERK), and c-Jun-N-terminal kinase…”
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DLX3 negatively regulates osteoclastic differentiation through microRNA-124
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Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ
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“ANE Downregulates Osteoclast-Specific Gene Expression NFATc1 is a master transcription factor for osteoclastogenesis (Asagiri et al., 2005; Kim and Kim, 2014), which controls the transcription of osteoclastogenesis-essential genes, including ATPase H+-transporting V0 subunit d2 (Atp6v0d2),…”
BackgroundScl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes
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“Under M-CSF induction, RANKL interacts with receptor activator of nuclear factor NF-kB (RANK) expressed on the surface of osteoclast precursors to trigger osteoclastogenesis-associated signals, leading to the upregulation of nuclear factor-κB (NF-κB), pro-osteoclastogenesis factor c-Fos, and master terminal transcript…”
BackgroundInhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy‐induced bone loss
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“NFAT is known as the master regulator of osteoclastogenesis and plays a role in osteoblast differentiation [49].”
BackgroundConversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells
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“the transcription factor, NFATc1, and their bone resorption is conducted with cathepsin K as a major proteinase [3,4].”
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“RANKL stimulates the expression of NFATc1 through NF-κB and c-Fos activation [49].”
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“NFATc1 is a master regulator responsible for osteoclastogenesis by regulating a series of downstream specific genes, such as that for CTSK, tartrate-resistant acid phosphatase (TRAP), c-Fos, and calcitonin receptor (CT) [86].”
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“Another report indicated that the absence of mice osteoclast-specific gene (NFATc1) impairs osteoclastogenesis and eventually leads to osteoporosis (46).”
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“NFATc1 is known to be the master transcriptional regulator of osteoclast differentiation [19].”
BackgroundThe deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling
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“The critical role of NFATC1 activity in osteoclastogenesis is well documented [52].”
BackgroundAMPKα1 negatively regulates osteoclastogenesis and mitigates pathological bone loss
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“NFATc1 expression during osteoclastogenesis is tightly regulated via the NF-κB and c-Fos signaling pathways [7,30].”
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Matrix-bound nanovesicles alleviate particulate-induced periprosthetic osteolysis
Liao, R., Dewey, M. J., Rong, J., Johnson, S. A., D’Angelo, W. A., Hussey, G. S., & Badylak, S. F. (2024) · Science Advances · doi:10.1126/sciadv.adn1852 · Cited by 20
“…expression of the master transcription factor NFATc1 and the osteoclast precursor multinucleation factor dendritic cell-specific transmembrane protein ( DC-STAMP ) was measured by reverse transcription quantitative polymerase chain reaction (RT-qPCR) 24 hours after MBV treatment ( 33 , 34 ).”
MethodInhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation
Kim, H. M., He, L., Lee, S., Park, C., Kim, D. H., Han, H.-J., Han, J., Hwang, J., Cha‐Molstad, H., Lee, K. H., et al. (2019) · Bone · doi:10.1016/j.bone.2019.115153 · Cited by 20
Zhang, S., Huo, S., Li, H., Tang, H., Nie, B., Qu, X., & Yue, B. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106014 · Cited by 19
Roles of osteoclast-associated receptor in rheumatoid arthritis and osteoarthritis
Kim, G. M., Park, H., & Lee, S. Y. (2022) · Joint Bone Spine · doi:10.1016/j.jbspin.2022.105400 · Cited by 20
Trang, N. M., Kim, E., Pham, T. H., & Jeong, G. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00368 · Cited by 21
Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
Song, M., Lee, Z. H., & Kim, H. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.94 · Cited by 20
Wang, J., Fu, B., Lu, F., Hu, X., Tang, J., & Huang, L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.091 · Cited by 20
Kim, H., Kim, C., Kook, K. E., Yanti, Y., Choi, S., Kang, W., & Hwang, J. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4155 · Cited by 20
Hwang, Y., Ha, H., 김라정, Cho, C., Song, Y., Hong, H., & Kim, T. S. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.075 · Cited by 21
Ahn, S. H., Chen, Z., Lee, J., Lee, S., Min, S. H., Kim, N. D., & Lee, T. (2018) · Molecules · doi:10.3390/molecules23123139 · Cited by 20
“NFATc1 is known to be a master transcriptional regulator of osteoclast differentiation [17].”
BackgroundSelf-citationRANKL-induced osteoclastogenesis in bone marrow-derived macrophages is suppressed by cisapride
Park, K., & Yun, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.05.010 · Cited by 20
Tian, K., Su, Y., Ding, J., Wang, D., Zhan, Y., Li, Y., Liang, J., Lin, X., Song, F., Wang, Z., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117336 · Cited by 20
Peng, J., Zhao, K., Zhu, J., Wang, Y., Sun, P., Yang, Q., Zhang, T., Han, W., Hu, W., Yang, W., et al. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s256867 · Cited by 21
Serine/threonine phosphatases in osteoclastogenesis and bone resorption
Karkache, I. Y., Damodaran, J. R., Molstad, D. H. H., & Bradley, E. W. (2020) · Gene · doi:10.1016/j.gene.2020.145362 · Cited by 20
“Zinc similarly inhibits Calcineurin activity within the RANKLinduced NFATc1 pathway (8).”
BackgroundInfluentialWang, B., Bai, S., Wang, J., Ren, N., Xie, R., Cheng, G., & Yu, Y. (2021) · Molecular Oral Microbiology · doi:10.1111/omi.12335 · Cited by 21
Chawalitpong, S., Chokchaisiri, R., Suksamrarn, A., Katayama, S., Mitani, T., Nakamura, S., Alathamneh, A., Ritprajak, P., Leelahavanichkul, A., Aeimlapa, R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23912-3 · Cited by 20
Kang, Y.-S., Kim, C., & Kim, J. (2017) · Physical Activity and Nutrition · doi:10.20463/jenb.2017.0010 · Cited by 19
Self-citationUndercarboxylated osteocalcin inhibits the early differentiation of osteoclast mediated by Gprc6a
Wang, H., Li, J., Xu, Z., Wu, F., Zhang, H., Yang, C., Chen, J., Bai, D., Sui, X., Guo, Z., et al. (2021) · PeerJ · doi:10.7717/peerj.10898 · Cited by 19
Chang, P., Wu, H.-K., Chen, Y.-H., Hsu, Y., Cheng, M.-T., Yu, C.-H., & Chen, S.-K. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07243-1 · Cited by 21
“The expression of bone resorption genes in differentiated osteoclasts were regulated by master regulator, nuclear factor activating transactivator NFAT1c [39].”
BackgroundQu, Z., An, H., Feng, M., Huang, W., Wang, D., Zhang, Z., & Yan, L. W. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17467 · Cited by 20
PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9
Sun, X., Li, K., Aryal, U. K., Li, B., & Yokota, H. (2022) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2022.08.003 · Cited by 19
“They also downregulated NFATc1 transcription factor and cathepsin K proteinase.(39,40) Since the osteolytic vicious cycle in breast cancer-associated bone metastasis is promoted”
New Perspectives of Therapies in Osteogenesis Imperfecta—A Literature Review
Dinulescu, A., Păsărică, A.-S., Carp, M., Dușcă, A., Dijmărescu, I., Pavelescu, M. L., Păcurar, D., & Ulici, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041065 · Cited by 19
“Another effect of Salubrinal is the suppression of RANKL activation [95–97].”
BackgroundJiménez-Ortega, R. F., Ortega-Meléndez, A. I., Patiño, N., Rivera‐Paredez, B., Hidalgo‐Bravo, A., & Velázquez‐Cruz, R. (2024) · Biology · doi:10.3390/biology13070505 · Cited by 19
“NFATc1 is a transcription factor that regulates osteoclast-specific gene expression such as tartrate-resistant acid phosphatase (TRAP), CTSK, calcitonin receptor (CGRP), osteoclast-associated receptor (OSCAR), and integrin 3 (ITGB3) [47].”
BackgroundUnited we stand: Adhesion and molecular mechanisms driving cell fusion across species
Zito, F., Lampiasi, N., Kireev, I. I., & Russo, R. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.09.002 · Cited by 18
Ceglie, I. D., van den Akker, G., Ascone, G., ten Harkel, B., Häcker, H., van de Loo, F. A. J., Koenders, M. I., van der Kraan, P. M., de Vries, T. J., Vogl, T. J., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ab0416-180rr · Cited by 19
“This is similar to an early block of differentiation into osteoclasts when the NFATc1 protein is knocked out [22, 23].”
BackgroundNatural uranium impairs the differentiation and the resorbing function of osteoclasts
Gritsaenko, T., Pierrefite‐Carle, V., Lorivel, T., Breuil, V., Carle, G. F., & Santucci‐Darmanin, S. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.01.008 · Cited by 19
Fu, F., Shao, S., Wang, Z., Song, F., Lin, X., Ding, J., Li, C., Wu, Z., Li, K., Yu, X., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27888 · Cited by 19
“NFATc1 played crucial roles in osteoclastogenesis and regulated by the calcium–calcineurin pathway and c‐Fos pathway (Alsaqati, Chan, & Ralevic, 2005; Asagiri & Takayanagi, 2007; Kim & Kim, 2014).”
BackgroundLee, Y. M., Kim, I. S., & Lim, B. O. (2019) · BioMed Research International · doi:10.1155/2019/5073085 · Cited by 19
“NFATc1 also induces many genes downstream of RANKL signaling, ultimately leading to increased osteoclast differentiation [51].”
BackgroundZhao, K., Jia, Y., Peng, J., Pang, C., Zhang, T., Han, W., Jiang, J., Lu, X., Zhu, J., & Qian, Y. (2019) · The FASEB Journal · doi:10.1096/fj.201802575rr · Cited by 20
Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4–IFN-β Axis
Kwon, J., Jin, W. J., Kim, B., Ha, H., Kim, H., & Lee, Z. H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800661 · Cited by 18
Trần, P. T., Park, D., Kim, O., Kwon, S., Min, B., & Lee, J. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3627 · Cited by 19
“The ERK, JNK, and p38 MAPK pathways are involved in the RANKL/RANK signaling pathway and are important in osteoclastogenesis through their regulation of the expression of NFATc1 via AP-1 transcription factors (9,37).”
Liu, Y., Zeng, W., Ma, C., Wang, Z., Wang, C., Li, S., He, W., Zhang, Q., Xu, J., & Zhou, C. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15647 · Cited by 18
Effects of Erythropoietin in White Adipose Tissue and Bone Microenvironment
Suresh, S., Lee, J., & Noguchi, C. T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584696 · Cited by 18
“7 cells (Kim et al., 2012; Kim and Kim, 2014).”
Zhang, Z., Song, J., Kwon, S., Wang, Z., Park, S., Piao, X., Ryu, J., Kim, N., Kim, O.-S., Kim, S.-H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108682 · Cited by 18
“RANKL activates the RANKL/RANK/TRAF6 pathways and its downstream NF-κB, MAPK, or PI3K/Akt pathways [23,24] to induce the expression of osteoclast-specific genes (Nfatc1, Ctsk, Trap, Mmp9) and osteoclastogenesis [25,26].”
BackgroundSelf-citationNovel insights of EZH2-mediated epigenetic modifications in degenerative musculoskeletal diseases
Ma, Z., Chen, L., Wang, Y., Zhang, S., Zheng, J., Luo, Y., Wang, C., Zeng, H., Xue, L., Tan, Z. W., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102034 · Cited by 19
Chen, X., Zhang, K., Hock, J. M., Wang, C., & Yu, X. (2016) · Bone Research · doi:10.1038/boneres.2016.35 · Cited by 18
c-Src–Dependent and –Independent Functions of Matk in Osteoclasts and Osteoblasts
Kim, J. H., Kim, K., Kim, I., Seong, S., & Kim, N. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700582 · Cited by 19
“Several transcription factors, such as c-Fos and NFATc1, are also known to regulate the differentiation and function of osteoclasts (4).”
BackgroundSelf-citationAnkle loading ameliorates bone loss from breast cancer–associated bone metastasis
Yang, S., Liu, H., Zhu, L., Li, X., Liu, D., Song, X., Yokota, H., & Zhang, P. (2019) · The FASEB Journal · doi:10.1096/fj.201900306rr · Cited by 18
Zavaczki, E., Gáll, T., Zarjou, A., Hendrik, Z., Potor, L., Tóth, C. Z., Méhes, G., Gyetvai, Á., Agarwal, A., Balla, G., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3721383 · Cited by 18
“…factor kappa-B (RANK) activating downstream genes including tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) [12], c-Jun N-terminal kinase (JNK) [13], p38 [14], nuclear factor-kappa B (NF κ B) [15], c-Fos [16], and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) [17].”
Impact of iron overload on bone remodeling in thalassemia
Piriyakhuntorn, P., Tantiworawit, A., Phimphilai, M., Shinlapawittayatorn, K., Chattipakorn, S. C., & Chattipakorn, N. (2020) · Archives of Osteoporosis · doi:10.1007/s11657-020-00819-z · Cited by 20
Metadata
- Authors
- Kim, J. H., & Kim, N.
- Affiliations
- Chonnam National University (KR)
- Corresponding author
- Kim, Nacksung
- Venue
- Journal of Bone Metabolism
- Published
- 2014
- Volume
- 21
- Issue
- 4
- Pages
- 233
- ISSN
- 2287-6375 (ISSN-L)
- 2287-7029
- PMC
- PMC4255043
- OpenAlex
- W2132541910
- Cited by
- 570
- References
- 69
- Citations by year
- 2026: 54 · 2025: 43 · 2024: 54 · 2023: 64 · 2022: 58 · 2021: 57 · 2020: 68 · 2019: 51 · 2018: 46 · 2017: 31 · 2016: 26 · 2015: 17
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Bone Metabolism (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- NFATc1, osteoclastogenesis, transcriptional regulation, epigenetic regulation, DNA methylation, ubiquitination, acetylation, non-coding RNA, macrophage colony-stimulating factor, RANKL, MITF, c-fos, NF-κB, bone resorption
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