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Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study
Open accessPreprint — published as 10.1186/s12916-021-01922-9 · Paper page
Abstract
Background: There is limited prospective evidence on the association between meat consumption and many common, non-cancerous health outcomes. We examined associations of meat intake with risk of 25 common conditions (other than cancer). Methods: We used data from 474 998 middle-aged men and women recruited into the UK Biobank study between 2006 and 2010 and followed-up until 2017 (mean follow-up of 8.0 years) with available information on meat intake at baseline (collected via touchscreen questionnaire), and linked hospital admissions and mortality data. For a large sub-sample, dietary intakes were re-measured using an online, 24-hour questionnaire. Results: In multi-variable adjusted (including body mass index (BMI)) Cox regression models corrected for multiple testing, a higher consumption of red and processed meat combined was associated with higher risks of ischaemic heart disease (HR per 70 g/day higher intake 1.14, 95% CI 1.06-1.22), pneumonia (1.28,1.15-1.41), diverticular disease (1.18,1.10-1.26), colon polyps (1.09,1.04-1.13), and diabetes (1.29,1.19-1.40), and a lower risk of iron deficiency anaemia (IDA), driven by a higher consumption of red meat (HR per 50g/day higher intake 0.77,0.69-0.86). Higher poultry meat intake was associated with higher risks of gastro-oesophageal reflux disease (HR per 30g/day higher intake 1.14, 1.06-1.23), gastritis and duodenitis (1.10,1.04-1.16), diverticular disease (1.09,1.04-1.16), and diabetes (1.13,1.06-1.20), and a lower risk of IDA (0.80,0.73-0.87). Conclusions: Higher red, processed, and poultry meat consumption was associated with higher risks of several common conditions; higher BMI accounted for a substantial proportion of these increased risks. Higher red and poultry meat consumption was associated with lower IDA risk.
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Metadata
- Authors
- Papier, K., Fensom, G. K., Knuppel, A., Appleby, P. N., Tong, T. Y., Schmidt, J. A., Travis, R. C., Key, T. J., & Perez-Cornago, A.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Papier, Keren
- ORCID
- Venue
- BMC Medicine
- Publisher
- openRxiv
- Published
- 2020-05-08
- Volume
- 19
- Issue
- 1
- Pages
- 53-53
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC7923515
- OpenAlex
- W3133399749
- Cited by
- 168
- References
- 2
- Citations by year
- 2026: 24 · 2025: 32 · 2024: 33 · 2023: 37 · 2022: 24 · 2021: 15 · 2020: 1
- FWCI
- 23.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Medicine (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wellcome Trust (205212, 205212/Z/16/Z, MR/M012190/1, 205212/Z/16)
- World Cancer Research Fund International (2019/1953)
- Cancer Research UK (C8221 / A29017, A29017, 29017, C60192/A28516, MR/M012190/1, C8211/A19170, 2019/1953, C8211/A29017)
- Medical Research Council (M012190/1, MR/M012190, MR/M012190/1, MC_PC_17228)
- World Cancer Research Fund (MR/M012190/1, 2019/1953)
- Medical Research Foundation (MR/M012190/1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Physical Sciences › Environmental Science › Ecology › Agriculture Sustainability and Environmental Impact
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- meat consumption, red meat, processed meat, poultry meat, ischemic heart disease, diverticular disease, colonic polyps, diabetes mellitus, iron deficiency anemia, gastroesophageal reflux disease, gastritis, pneumonia, body mass index, dietary intake, hospitalization, mortality, UK Biobank, middle-aged adults
- MeSH terms
- Red Meat, Animals, Female, United Kingdom, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Biological Specimen Banks
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