Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera
Open accessAbstract
Rapidly spreading variants of SARS-CoV-2 that have arisen in the United Kingdom and South Africa share the spike N501Y substitution, which is of particular concern because it is located in the viral receptor binding site for cell entry and increases binding to the receptor (angiotensin converting enzyme 2). We generated isogenic N501 and Y501 SARS-CoV-2. Sera of 20 participants in a previously reported trial of the mRNA-based COVID-19 vaccine BNT162b2 had equivalent neutralizing titers to the N501 and Y501 viruses.
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Other groups have reported comparable findings with vaccinee and convalescent plasma across various pseudotype and authentic virus assays.
“In addition, similar results have been reported by others using vaccinee and convalescent plasmas and a variety of different pseudotype and authentic virus assays15,31,45–49.”
From mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants (2021) · cites this paper as [46]
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Cites
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MethodSelf-citationStructural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
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“This is supported by recent evidence that sera from vaccinated individuals elicits equivalent neutralising titres to VOC 202012/01 and similar variants to that seen with previous strains.(32, 33)”
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Günl, F., Mecate-Zambrano, A., Rehländer, S., Hinse, S., Ludwig, S., & Brunotte, L. (2021) · Vaccines · doi:10.3390/vaccines9101052 · Cited by 27 · see citing works
- Authors
- Xie, X., Zou, J., Fontes-Garfias, C. R., Xia, H., Swanson, K. A., Cutler, M., Cooper, D., Menachery, V. D., Weaver, S., Dormitzer, P. R., & Shi, P.-Y.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Pfizer (United States) (US)
- Corresponding author
- Dormitzer, Philip R.
- Shi, Pei-Yong
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2021-01-07
- PMC
- PMC7805448
- OpenAlex
- W3120924815
- Cited by
- 143
- References
- 8
- Citations by year
- 2024: 5 · 2023: 5 · 2022: 24 · 2021: 109
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nc-nd)
- Funders
- Amon G. Carter Foundation
- Pfizer (C4591001)
- John S. Dunn Foundation (AI145617)
- Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation (AI134907)
- National Institutes of Health (AI142759, UL1TR001439)
- National Institute of Allergy and Infectious Diseases (R43AI145617, R01AI134907, U19AI142759)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- SARS-CoV-2, N501Y mutation, spike protein, BNT162b2, mRNA vaccines, neutralizing antibodies, receptor binding domain, ACE2 binding, COVID-19 vaccine efficacy
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