ColabFold - Making protein folding accessible to all

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Items 301–400 of 1,085

1. A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector
   Xiao Lin, Andrea Carolina Olave-Achury, Robert Heal, Marina Pais, Kamil Witek, Hee-Kyung Ahn, He Zhao, Shivani Bhanvadia, Hari S. Karki, Tianqiao Song et al. · 2022 · Molecular Plant
2. Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors
   2023
3. Cryo-EM structure of the bacterial divisome core complex and antibiotic target FtsWIQBL
   Lisa Käshammer, Fusinita van den Ent, Magnus Jeffery, Nicolas L. Jean, Victoria L. Hale, Jan Löwe · 2023 · Nature Microbiology
4. Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging
   Yusuke Nasu, Abhi Aggarwal, Giang N. T. Le, Camilla Trang Vo, Yuki Kambe, Xinxing Wang, Felix R. M. Beinlich, Ashley Bomin Lee, Tina R. Ram, Fangying Wang et al. · 2023 · Nature Communications
5. Anaerostipes hadrus , a butyrate-producing bacterium capable of metabolizing 5-fluorouracil
   Danping Liu, Lisheng Xie, Shitao Lian, Kexin Li, Yun Kai Yang, Wen-Zhao Wang, Songnian Hu, Shuang‐Jiang Liu, Chang Liu, Zilong He · 2024 · mSphere
6. Rescaling protein-protein interactions improves Martini 3 for flexible proteins in solution
   F. Emil Thomasen, Tórur Skaalum, Ashutosh Kumar, Sriraksha Srinivasan, Stefano Vanni, Kresten Lindorff‐Larsen · 2024 · Nature Communications
7. A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity
   Jogi Madhuprakash, AmirAli Toghani, Mauricio P. Contreras, Andrés Posbeyikian, Jake Richardson, Jiorgos Kourelis, Tolga O. Bozkurt, Michael Webster, Sophien Kamoun · 2024 · Science Advances
8. Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses
   Yang, Shaobo, Sheffer, Michal, Kaplan, Isabel E., Wang, Zongqi, Tarannum, Mubin, Dinh, Khanhlinh, Abdulhamid, Yasmin, Bobilev, Eden, Shapiro, Roman, Porter, Rebecca et al. · 2025 · Nature Biotechnology
9. Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects
   Yufei Wang, Alicia Buck, Brandon P. Piel, Luann Zerefa, Nithyassree Murugan, Christian D. Coherd, Andras G. Miklosi, H. Johal, Ricardo Nunes Bastos, Kun Huang et al. · 2024 · Molecular Cancer
10. Stability Oracle: a structure-based graph-transformer framework for identifying stabilizing mutations
    Daniel J. Diaz, Chengyue Gong, Jeffrey Ouyang-Zhang, James M. Loy, Jordan Wells, David K. Yang, Andrew D. Ellington, Alexandros G. Dimakis, Adam R. Klivans · 2024 · Nature Communications
11. Prediction of multiple conformational states by combining sequence clustering with AlphaFold2
    Hannah K. Wayment-Steele, Sergey Ovchinnikov, Lucy J. Colwell, Dorothee Kern · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
12. Antiviral signalling by a cyclic nucleotide activated CRISPR protease
    Rouillon, Christophe, Schneberger, Niels, Chi, Haotian, Blumenstock, Katja, Da Vela, Stefano, Ackermann, Katrin, Moecking, Jonas, Peter, Martin F., Boenigk, Wolfgang, Seifert, Reinhard et al. · 2023 · Nature
13. Type VI secretion systems of pathogenic and commensal bacteria mediate niche occupancy in the gut
    Antonio Serapio-Palacios, Sarah E. Woodward, Stefanie L Vogt, Wanyin Deng, Anna Creus-Cuadros, Kelsey E. Huus, Mihai S. Cirstea, Madeleine Gerrie, Weronika Barcik, Hongbing Yu et al. · 2022 · Cell Reports
14. Mutations in the monkeypox virus replication complex: Potential contributing factors to the 2022 outbreak
    Saathvik R. Kannan, Shrikesh Sachdev, Athreya S. Reddy, Shree Lekha Kandasamy, Siddappa N. Byrareddy, Christian L. Lorson, Kamal Singh · 2022 · Journal of Autoimmunity
15. Flavivirus nonstructural proteins and replication complexes as antiviral drug targets
    Kaïn van den Elsen, Bing Liang Alvin Chew, Jun Sheng Ho, Dahai Luo · 2023 · Current Opinion in Virology
16. Using AlphaFold Predictions in Viral Research
    Daria Gutnik, Peter V. Evseev, Мирошников Константин Анатольевич, Mikhail M. Shneider · 2023 · Current Issues in Molecular Biology
17. Resurrection of plant disease resistance proteins via helper NLR bioengineering
    Mauricio P. Contreras, Hsuan Pai, Muniyandi Selvaraj, AmirAli Toghani, David M. Lawson, Yasin Tümtaş, Cian Duggan, Enoch Lok Him Yuen, Clare E. M. Stevenson, Adeline Harant et al. · 2023 · Science Advances
18. A cryptic plasmid is among the most numerous genetic elements in the human gut
    Emily C. Fogarty, Matthew S. Schechter, Karen Lolans, Madeline L. Sheahan, Iva Veseli, Ryan M. Moore, Evan Kiefl, Thomas U. Moody, Phoebe A. Rice, Michael Yu et al. · 2024 · Cell
19. ModelArchive: A Deposition Database for Computational Macromolecular Structural Models
    Gerardo Tauriello, Andrew Mark Waterhouse, Juergen Haas, Dario Behringer, Stefan Bienert, Thomas Garello, Torsten F. Schwede · 2025 · Journal of Molecular Biology
20. AlphaDesign: A <i>de novo</i> protein design framework based on AlphaFold
    Jendrusch, Michael, Korbel, Jan O., Sadiq, S. Kashif · 2021
21. BTB domains: A structural view of evolution, multimerization, and protein–protein interactions
    Artem N. Bonchuk, Konstantin Balagurov, Pavel G Georgiev · 2022 · BioEssays
22. The structural repertoire of Fusarium oxysporum f. sp. lycopersici effectors revealed by experimental and computational studies
    Daniel S. Yu, Megan A. Outram, Ashley Smith, Carl L. McCombe, Pravin B. Khambalkar, Sharmin A. Rima, Xizhe Sun, Lisong Ma, Daniel J. Ericsson, David A. Jones et al. · 2023 · eLife
23. Rapid bacteria-phage coevolution drives the emergence of multiscale networks
    Joshua M. Borin, Justin J. Lee, Adriana Lucía-Sanz, Krista R. Gerbino, Joshua S. Weitz, Justin R. Meyer · 2023 · Science
24. Putting <i>AlphaFold</i> models to work with <i>phenix.process_predicted_model</i> and <i>ISOLDE</i>
    Oeffner, Robert D., Croll, Tristan I., Millán, Claudia, Poon, Billy K., Schlicksup, Christopher J., Read, Randy J., Terwilliger, Tom C. · 2022 · Acta Crystallographica Section D Structural Biology
25. Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus
    Clémence David, Carlos A. Arango-Franco, Mihaly Badonyi, Julien Fouchet, Gillian Rice, Blaise Didry‐Barca, Lucie Maisonneuve, Luís Seabra, Robin Kechiche, Cécile Masson et al. · 2024 · The Journal of Experimental Medicine
26. The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunity
    Kaori Oikawa, Koki Fujisaki, Motoki Shimizu, Takumi Takeda, Keiichiro Nemoto, Hiromasa Saitoh, Akiko Hirabuchi, Yukie Hiraka, Naomi Miyaji, Aleksandra Białas et al. · 2024 · PLoS Pathogens
27. Language Modeling Materializes a World Model of Protein Biology
    Salvatore Candido, Thomas Hayes, Alexander Derry, Roshan Rao, Zeming Lin, Robert Verkuil, Bryan Z. Wu, Jin Sub Lee, Elise S. Bruguera, Jehan A. Keval et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
28. A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
    Vides, Edmundo G, Adhikari, Ayan, Chiang, Claire Y, Lis, Pawel, Purlyte, Elena, Limouse, Charles, Shumate, Justin L, Spínola-Lasso, Elena, Dhekne, Herschel S, Alessi, Dario R et al. · 2022 · eLife
29. Lipid scrambling is a general feature of protein insertases
    Li, Dazhi, Rocha-Roa, Cristian, Schilling, Matthew A., Reinisch, Karin M., Vanni, Stefano · 2024 · Proceedings of the National Academy of Sciences
30. Accelerating crystal structure determination with iterative <i>AlphaFold</i> prediction
    Terwilliger, Thomas C., Afonine, Pavel V., Liebschner, Dorothee, Croll, Tristan I., McCoy, Airlie J., Oeffner, Robert D., Williams, Christopher J., Poon, Billy K., Richardson, Jane S., Read, Randy J. et al. · 2023 · Acta Crystallographica Section D Structural Biology
31. Equivariant Graph Neural Networks for Toxicity Prediction
    Cremer, Julian, Medrano Sandonas, Leonardo, Tkatchenko, Alexandre, Clevert, Djork-Arné, De Fabritiis, Gianni · 2023 · Chemical Research in Toxicology
32. TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids
    Alex Reed, Timothy B. Ware, Haoxin Li, J. Fernando Bazán, Benjamin F. Cravatt · 2023 · Nature Chemical Biology
33. A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription
    Chris Estell, Lee Davidson, Joshua D Eaton, Hiroshi Kimurâ, Vicki A. M. Gold, Steven West · 2023 · Molecular Cell
34. Integrating deep learning, threading alignments, and a multi‐MSA strategy for high‐quality protein monomer and complex structure prediction in CASP15
    Wei Hui Zheng, Qiqige Wuyun, Lydia Freddolino, Yang Zhang · 2023 · Proteins Structure Function and Bioinformatics
35. Computational drug development for membrane protein targets
    Haijian Li, Xiaolin Sun, Wenqiang Cui, Marc Xu, Junlin Dong, Babatunde Ekundayo, Dongchun Ni, Zhili Rao, Liwei Guo, Henning Stahlberg et al. · 2024 · Nature Biotechnology
36. MolPhase, an advanced prediction algorithm for protein phase separation
    Qiyu Liang, Nana Peng, Yi Xie, Nivedita Kumar, Weibo Gao, Yansong Miao · 2024 · The EMBO Journal
37. Cryo-EM structure of gas vesicles for buoyancy-controlled motility
    Huber, Stefan T., Terwiel, Dion, Evers, Wiel H., Maresca, David, Jakobi, Arjen J. · 2023 · Cell
38. DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing
    Mi Li, Ming Shi, Yuxuan Li, Gang Xie, Xichen Rao, Damu Wu, Aimin Cheng, Mengxiao Niu, Fengli Xu, Ying Yu et al. · 2023 · Nature Communications
39. Open-Source Machine Learning in Computational Chemistry
    Alexander Hagg, Karl N. Kirschner · 2023 · Journal of Chemical Information and Modeling
40. AI for targeted polypharmacology: The next frontier in drug discovery
    Anna Cichońska, Balaguru Ravikumar, Rayees Rahman · 2024 · Current Opinion in Structural Biology
41. Diversity and potential host-interactions of viruses inhabiting deep-sea seamount sediments
    Meishun Yu, Menghui H. Zhang, Runying Zeng, Ruolin Cheng, Rui Zhang, Yanping Hou, Fangfang Kuang, Xuejin Feng, Xiyang Dong, Yinfang Li et al. · 2024 · Nature Communications
42. Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA
    Max E. Wilkinson, David Li, Linyi Gao, Rhiannon K. Macrae, Feng Zhang · 2024 · Science
43. The stem rust effector protein AvrSr50 escapes Sr50 recognition by a substitution in a single surface‐exposed residue
    Diana Ortiz, Jian Chen, Megan A. Outram, Isabel M. L. Saur, Narayana M. Upadhyaya, Rohit Mago, Daniel J. Ericsson, Stella Césari, Chunhong Chen, Simon J. Williams et al. · 2022 · New Phytologist
44. Single-cell analysis identifies genes facilitating rhizobium infection in Lotus japonicus
    Manuel Frank, Lavinia Ioana Fechete, Francesca Tedeschi, Marcin Nadzieja, Malita Malou Malekzadeh Nørgaard, Jesús Montiel, Kasper R. Andersen, Mikkel Heide Schierup, Dugald E. Reid, Stig Uggerhøj Andersen · 2023 · Nature Communications
45. Complete computational design of high-efficiency Kemp elimination enzymes
    Dina Listov, Eva Vos, Gyula Hoffka, Shlomo Yakir Hoch, Andrej Berg, Shelly Hamer-Rogotner, Orly Dym, Shina Caroline Lynn Kamerlin, Sarel Jacob Fleishman · 2025 · Nature
46. Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution
    Castro, Inês Gomes, Shortill, Shawn P, Dziurdzik, Samantha Katarzyna, Cadou, Angela, Ganesan, Suriakarthiga, Valenti, Rosario, David, Yotam, Davey, Michael, Mattes, Carsten, Thomas, Ffion B et al. · 2022 · eLife
47. How to build a ribosome from RNA fragments in Chlamydomonas mitochondria
    Florent Waltz, Thalia Salinas‐Giegé, Robert Englmeier, Herrade Meichel, Heddy Soufari, Lauriane Kühn, Stefan Pfeffer, Friedrich G. Förster, Benjamin D. Engel, Philippe Giegé et al. · 2021 · Nature Communications
48. AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs
    Tarhan Ibrahim, Virendrasinh S Khandare, Federico Gabriel Mirkin, Yasin Tümtaş, Doryen Bubeck, Tolga O. Bozkurt · 2023 · PLoS Biology
49. Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer
    Hilal Keskin Karakoyun, Şirin Yüksel, Ilayda Amanoglu, Lara Naserikhojasteh, Ahmet Yeşilyurt, Cengiz Yakıcıer, Emel Timuçin, Cemaliye Boylu Akyerli · 2023 · Frontiers in Genetics
50. Central role of Tim17 in mitochondrial presequence protein translocation
    Laura F. Fielden, Jakob D. Busch, Sandra G. Merkt, Iniyan Ganesan, Conny Steiert, H. Hasselblatt, Jon V. Busto, Christophe Wirth, Nicole Zufall, Sibylle Jungbluth et al. · 2023 · Nature
51. PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
    Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia A. Prokhorova, Nicolas Bigot, Domagoj Baretić, Juraj Ahel et al. · 2024 · The EMBO Journal
52. Sculpting conducting nanopore size and shape through de novo protein design
    Samuel Berhanu, Sagardip Majumder, Thomas Müntener, James M. Whitehouse, Carolin Berner, Asim K. Bera, Alex Kang, Binyong Liang, G. Nasir Khan, Banumathi Sankaran et al. · 2024 · Science
53. Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases
    Peter H. Yoon, Zeyuan Terry Zhang, Kenneth J. Loi, Benjamin A. Adler, Arushi Lahiri, Kamakshi Vohra, Honglue Shi, Daniel Bellieny Rabelo, Marena I. Trinidad, Ron S. Boger et al. · 2024 · Science
54. Code to complex: AI-driven de novo binder design
    Daniel Fox, Cyntia Taveneau, Janik Clement, Rhys Grinter, Gavin J. Knott · 2025 · Structure
55. UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
    Yeo, Megan J. R., Zhang, Olivia, Xie, Xiaowen, Nam, Eunju, Payne, N. Connor, Gosavi, Pallavi M., Kwok, Hui Si, Iram, Irtiza, Lee, Ceejay, Li, Jiaming et al. · 2025 · Nature
56. Structure and sucrose binding mechanism of the plant SUC1 sucrose transporter
    Laust Bavnhøj, Jan Heiner Driller, Lorena Zuzic, Amanda Dyrholm Stange, Birgit Schiøtt, Bjørn Panyella Pedersen · 2023 · Nature Plants
57. Computer-Aided Drug Discovery and Design: Recent Advances and Future Prospects
    Alan Talevi · 2023 · Methods in molecular biology
58. An intermediate Rb–E2F activity state safeguards proliferation commitment
    Yumi Konagaya, David Rosenthal, Nalin Ratnayeke, Yilin Fan, Tobias Meyer · 2024 · Nature
59. De novo gene synthesis by an antiviral reverse transcriptase
    Tang, Stephen, Conte, Valentin, Zhang, Dennis J., Žedaveinytė, Rimantė, Lampe, George D., Wiegand, Tanner, Tang, Lauren C., Wang, Megan, Walker, Matt W. G., George, Jerrin Thomas et al. · 2024 · Science
60. Predicting protein conformational motions using energetic frustration analysis and AlphaFold2
    Xingyue Guan, Qian-Yuan Tang, Weitong Ren, Mingchen Chen, Wei Wang, Peter Guy Wolynes, Wenfei Li · 2024 · Proceedings of the National Academy of Sciences
61. CARD domains mediate anti-phage defence in bacterial gasdermin systems
    Tanita Wein, Adi Millman, Katharina Lange, Erez Yirmiya, Romi Hadary, Jeremy Garb, Sarah Melamed, Gil Amitai, Orly Dym, Felix Steinruecke et al. · 2025 · Nature
62. Molecular Modelling in Bioactive Peptide Discovery and Characterisation
    Clement Agoni, Raúl Fernández-Díaz, Patrick Brendan Timmons, Alessandro Adelfio, Hansel Gómez, Denis C. Shields · 2025 · Biomolecules
63. AlphaFold 3: an unprecedent opportunity for fundamental research and drug development
    Ziqi Fang, Hongbiao Ran, YongHan Zhang, Chensong Chen, Lin Ping, Xiang Zhang, Min Wu · 2025 · Precision Clinical Medicine
64. Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole
    Jierui Zhao, Mai Thu Bui, Juncai Ma, Fabian Künzl, Lorenzo Picchianti, Juan Carlos De la Concepción, Yixuan Chen, Sofia Petsangouraki, Azadeh Mohseni, Marta García-León et al. · 2022 · The Journal of Cell Biology
65. Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
    Larissa Dietz, Cara J. Ellison, Carlos Riechmann, C. Keith Cassidy, F. Daniel Felfoldi, Adán Pinto-Fernández, Benedikt Mathias Kessler, P.R. Elliott · 2023 · Science
66. Subcellular location defines GPCR signal transduction
    Arthur Radoux-Mergault, Lucie Oberhauser, Simone Aureli, Francesco Luigi Gervasio, Miriam Stoeber · 2023 · Science Advances
67. Volatile communication in plants relies on a KAI2-mediated signaling pathway
    Shannon A. Stirling, Angelica M. Guercio, Ryan M. Patrick, Xingqi Huang, Matthew E. Bergman, Varun Dwivedi, Ruy Kortbeek, Yi‐Kai Liu, Fuai Sun, W. Andy Tao et al. · 2024 · Science
68. Diverse and abundant phages exploit conjugative plasmids
    Natalia Quinones‐Olvera, Siân V. Owen, Lucy M. McCully, Maximillian G. Marin, Eleanor A. Rand, Alice C. Fan, Oluremi J. Martins Dosumu, Kay Paul, Cleotilde E. Sanchez Castaño, Rachel Petherbridge et al. · 2024 · Nature Communications
69. DeepEnzyme: a robust deep learning model for improved enzyme turnover number prediction by utilizing features of protein 3D-structures
    Wang, Tong, Xiang, Guangming, He, Siwei, Su, Liyun, Wang, Yuguang, Yan, Xuefeng, Lu, Hongzhong · 2024 · Briefings in Bioinformatics
70. Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier
    Tyler Chistopher Moyer, Brett A. Hoffman, Weitong Chen, Ishan S. Shah, Xiao‐Qin Ren, Tatiana M. Knox, Jiachen Liu, Wei Wang, Jiangyu Li, Hamza Khalid et al. · 2025 · Molecular Therapy
71. The Virtual Lab: AI Agents Design New SARS-CoV-2 Nanobodies with Experimental Validation
    Swanson, Kyle, Wu, Wesley, Bulaong, Nash L., Pak, John E., Zou, James · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
72. Revolutionizing <scp>peptide‐based</scp> drug discovery: Advances in the <scp>post‐AlphaFold</scp> era
    Chang, Liwei, Mondal, Arup, Singh, Bhumika, Martínez‐Noa, Yisel, Perez, Alberto · 2024 · WIREs Computational Molecular Science
73. Exploring protein-protein interactions at the proteome level
    Hadeer Elhabashy, Felipe Merino, Vikram Alva, Oliver Kohlbacher, Andrei N. Lupas · 2022 · Structure
74. Cell types and molecular architecture of the Octopus bimaculoides visual system
    Jeremea O. Songco-Casey, Gabrielle C. Coffing, Denise M. Piscopo, Judit R. Pungor, Andrew D. Kern, Adam C. Miller, Cristopher M. Niell · 2022 · Current Biology
75. Structural basis of Janus kinase trans-activation
    Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, K. Christopher García · 2023 · Cell Reports
76. SARS-CoV-2 Exposure in Norway Rats (Rattus norvegicus) from New York City
    Yang Wang, Julianna B. Lenoch, D Köhler, Thomas Jude Deliberto, Cynthia Y. Tang, Tao Li, Yizhi Jane Tao, Minhui Guan, Susan R Compton, Caroline J. Zeiss et al. · 2023 · mBio
77. Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation
    Ecco Staller, Loïc Carrique, Olivia C. Swann, Haitian Fan, J.R. Keown, Carol Sheppard, William Barclay, Jonathan M. Grimes, Ervin Fodor · 2024 · Nature Communications
78. A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance
    Juntao Yu, Yujie Zhang, Yimeng Fang, João A. Paulo, Dadmehr Yaghoubi, Xu Hua, Gergana G. Shipkovenska, Takenori Toda, Zhiguo Zhang, Steven P. Gygi et al. · 2024 · Cell
79. Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
    Jan de Witt, Tom Luthe, Johanna Wiechert, Kenneth Jensen, Tino Polen, Astrid Wirtz, Stephan Thies, Julia Frunzke, Benedikt Wynands, Nick J. P. Wierckx · 2025 · Nature Microbiology
80. actifpTM: a refined confidence metric of AlphaFold2 predictions involving flexible regions
    Julia K. Varga, Sergey Ovchinnikov, Ora Schueler‐Furman · 2025 · Bioinformatics
81. TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux
    Joanne F. Garbincius, Oniel Salik, Henry M. Cohen, Carmen Choya-Foces, Adam S. Mangold, Angelina D Makhoul, Anna E. Schmidt, Dima Y. Khalil, Joshua J. Doolittle, Anya S. Wilkinson et al. · 2025 · Nature Metabolism
82. TIR domains produce histidine-ADPR as an immune signal in bacteria
    Dziugas Sabonis, Carmel Avraham, Renee B. Chang, Allen Lu, Ehud Herbst, Arūnas Šilanskas, Deividas Vilutis, Azita Leavitt, Erez Yirmiya, Hunter C. Toyoda et al. · 2025 · Nature
83. RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease
    Kazuki Kato, Sae Okazaki, Cian Schmitt-Ulms, Kaiyi Jiang, Wenyuan Zhou, Junichiro Ishikawa, Yukari Isayama, Shungo Adachi, Tomohiro Nishizawa, Kira S. Makarova et al. · 2022 · Science
84. DNA end sensing and cleavage by the Shedu anti-phage defense system
    Loeff, Luuk, Walter, Alexander, Rosalen, Gian Tizio, Jinek, Martin · 2025 · Cell
85. Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
    Gerlach, Piotr, Garland, William, Lingaraju, Mahesh, Salerno-Kochan, Anna, Bonneau, Fabien, Basquin, Jérôme, Jensen, Torben Heick, Conti, Elena · 2022 · Molecular Cell
86. ProT‐Diff: A Modularized and Efficient Strategy for De Novo Generation of Antimicrobial Peptide Sequences by Integrating Protein Language and Diffusion Models
    2024
87. Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection
    Guochao Wei, Naseer Iqbal, Valentine V. Courouble, Ashwanth Christopher Francis, Parmit Kumar Singh, Arpa Hudait, Arun S. Annamalai, Stephanie M. Bester, Szu‐Wei Huang, Nikoloz Shkriabai et al. · 2022 · Nature Communications
88. Large-scale invasion of unicellular eukaryotic genomes by integrating DNA viruses
    Christopher M. Bellas, Thomas Hackl, Marie-Sophie Plakolb, Anna Koslová, Matthias Fischer, Rubén Sommaruga · 2023 · Proceedings of the National Academy of Sciences
89. An end-to-end deep learning method for protein side-chain packing and inverse folding
    Matt McPartlon, Jinbo Xu · 2023 · Proceedings of the National Academy of Sciences
90. Patterns of recombination in snakes reveal a tug-of-war between PRDM9 and promoter-like features
    Carla Hoge, Marc de Manuel, Mohamed Mahgoub, Naima Okami, Zachary L. Fuller, Shreya M. Banerjee, Zachary Baker, Morgan McNulty, Peter Andolfatto, Todd S. Macfarlan et al. · 2024 · Science
91. The future of integrated structural biology
    Harald Schwalbe, Pauline N. C. B. Audergon, Natalie Haley, Claudia Alen Amaro, Jon Agirre, Marc Baldus, Lucia Banci, Wolfgang P. Baumeister, Martin J Blackledge, J.M. Carazo et al. · 2024 · Structure
92. Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex
    Owen T. Tuck, Benjamin A. Adler, Emily G. Armbruster, Arushi Lahiri, Jason J. Hu, Julia Zhou, Joe Pogliano, Jennifer A. Doudna · 2024 · Cell
93. Transposable element exonization generates a reservoir of evolving and functional protein isoforms
    Yago A. Arribas, Blandine Baudon, Maxime Rotival, Guadalupe Suárez, Pierre‐Emmanuel Bonté, Vanessa Casas, Apollinaire Roubert, Paul Klein, Elisa Bonnin, Basma Mchich et al. · 2024 · Cell
94. Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense
    VanderWal, Arica R., Park, Jung-Un, Polevoda, Bogdan, Nicosia, Julia K., Molina Vargas, Adrian M., Kellogg, Elizabeth H., O’Connell, Mitchell R. · 2023 · Science
95. Folding the unfoldable: using AlphaFold to explore spurious proteins
    Vivian Monzon, Daniel H. Haft, Alex G. Bateman · 2021 · Bioinformatics Advances
96. The two-domain elevator-type mechanism of zinc-transporting ZIP proteins
    Anders Wiuf, Jonas Hyld Steffen, Eva Ramos Becares, Christina Grønberg, Dhani Ram Mahato, Søren G. F. Rasmussen, Magnus Andersson, Tristan Ian Croll, Kamil Gotfryd, Pontus Emanuel Gourdon · 2022 · Science Advances
97. Co-evolution-based prediction of metal-binding sites in proteomes by machine learning
    Yao Cheng, Haobo Wang, Hua Xu, Yuan Liu, Bin Ma, Xuemin Chen, Xin Zeng, Xianghe Wang, Bo Wang, Carina Shiau et al. · 2023 · Nature Chemical Biology
98. Three neutralizing mAbs induced by MPXV A29L protein recognizing different epitopes act synergistically against orthopoxvirus
    Mengjun Li, Zuning Ren, Yuelin Wang, Yushan Jiang, Minghui Yang, Delin Li, Jiayin Chen, Zuxin Liang, Yuhao Lin, Zhujun Zeng et al. · 2023 · Emerging Microbes & Infections
99. Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM
    Hanwen Zhu, Patricia M. Hixson, Wen Ma, Ji Sun · 2024 · Cell Discovery
100. HighFold: accurately predicting structures of cyclic peptides and complexes with head-to-tail and disulfide bridge constraints
     Chenhao Zhang, Chengyun Zhang, Tianfeng Shang, Ning Zhu, Xinyi Wu, Hongliang Duan · 2024 · Briefings in Bioinformatics