The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Nodal Morphogens
Open accessAbstract
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.
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Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
Self-citationMicroRNAs Regulate Brain Morphogenesis in Zebrafish
Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., Hammond, S. M., Bartel, D. P., & Schier, A. F. (2005) · Science · doi:10.1126/science.1109020 · Cited by 1,315
Self-citationMaking a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · cited 2×
“Cerberus and Cerberus-like proteins like Charon bind directly to Nodal, inhibit its binding to receptors, and thus regulate embryonic patterning (Bouwmeester et al. 1996; Piccolo et al. 1999; Bertocchini and Stern 2002; Silva et al. 2003; Hashimoto et al. 2004; Marques et al. 2004; Yamamoto et al. 2004; Tavares et al.…”
BackgroundFAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination
Dupont, S., Mamidi, A., Cordenonsi, M., Montagner, M., Zacchigna, L., Adorno, M., Martello, G., Stinchfield, M. J., Soligo, S., Morsut, L., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.051 · Cited by 494
Conserved Patterns of Cell Movements during Vertebrate Gastrulation
Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
Hart, A. H., Hartley, L., Sourris, K., Stadler, E. S., Li, R., Stanley, E. G., Tam, P. P. L., Elefanty, A. G., & Robb, L. (2002) · Development · doi:10.1242/dev.129.15.3597 · Cited by 229
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
Dyson, S., & Gurdon, J. B. (1998) · Cell · doi:10.1016/s0092-8674(00)81185-x · Cited by 204
Cited by
Koh, K. P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C. A., Mostoslavsky, G., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.01.008 · Cited by 776
The TGFbeta Superfamily Signaling Pathway
Weiss, A., & Attisano, L. (2013) · WIREs Developmental Biology · doi:10.1002/wdev.86 · Cited by 561
Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring
Finnson, K. W., McLean, S., Di Guglielmo, G. M., & Philip, A. (2013) · Advances in Wound Care · doi:10.1089/wound.2013.0429 · Cited by 300
Chow, M. L., Pramparo, T., Winn, M. E., Barnes, C. C., Li, H.-R., Weiss, L., Fan, J.-B., Murray, S., April, C., Belinson, H., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002592 · Cited by 202
Activin/nodal signalling in stem cells
Pauklin, S., & Vallier, L. (2015) · Development · doi:10.1242/dev.091769 · Cited by 195
Metadata
- Authors
- Schier, A. F.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-08-26
- Volume
- 1
- Issue
- 5
- Pages
- a003459-a003459
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W4211028684
- Cited by
- 248
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
