The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR
Open accessAbstract
Caenorhabditis elegans let-7 , a founding member of the microRNA family, is predicted to bind to six sites in the 3′UTR of the mRNA of its target gene, lin-41 , to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3′UTR. This interaction is dependent on two conserved let-7 complementary sites (LCSs). A 27-nucleotide sequence between the LCSs is also necessary for down-regulation in vivo. LCS mutations compensatory to the lesion in let-7(n2853) can partially restore lin-41 3′UTR function in a let-7(n2853) background, providing the first experimental evidence for an animal miRNA binding directly to its validated target in vivo.
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Cited by
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Self-citation
Metadata
- Authors
- Vella, M. C., Choi, E.-Y., Lin, S.-Y., Reinert, K., & Slack, F. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-01-15
- Volume
- 18
- Issue
- 2
- Pages
- 132-137
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2167018551
- Cited by
- 442
- References
- 10
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Vella, M. C., Choi, E.-Y., Lin, S.-Y., Reinert, K., & Slack, F. J. (2004). The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR. Genes & Development. https://doi.org/10.1101/gad.1165404
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