Cited by 122Adipokines, Inflammation, and Metabolic DiseasesProtein Tyrosine PhosphatasesMetabolism, Diabetes, and Cancer

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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

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Jaeschke, Anja, Czech, Michael P., Davis, Roger J.·2004·Genes & Development

DOI 10.1101/gad.1216504PMC PMC514178

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Abstract

The c-Jun NH 2-terminal kinase (JNK) is activated during obesity. One consequence of obesity is that JNK phosphorylates the adapter protein insulin receptor substrate 1 (IRS-1) on Ser 307 and inhibits signaling by the insulin receptor. JNK can therefore cause peripheral insulin resistance during obesity and may contribute to the development of type 2 diabetes. Here we report that the JNK-interacting protein 1 (JIP1) scaffold protein, which binds components of the JNK signaling module, is essential for JNK activation in the adipose tissue of obese mice. These data identify JIP1 as a novel molecular target for therapeutic intervention in the development of obesity.

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Authors: Jaeschke, A., Czech, M. P., & Davis, R. J.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Jaeschke, Anja
Czech, Michael P.
Davis, Roger J.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2004-08-15
Volume: 18
Issue: 16
Pages: 1976-1980
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1216504
PMC: PMC514178
OpenAlex: W2156584134
Cited by: 121
References: 26
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 3
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: JIP1, JNK activation, c-Jun NH2-terminal kinase, adipose tissue, obesity, insulin resistance, IRS-1, type 2 diabetes, scaffold proteins
MeSH terms: Adipose Tissue, Animals, Diet, Enzyme Activation, Insulin Resistance, Mice, Inbred C57BL, Nuclear Proteins, Trans-Activators, Mitogen-Activated Protein Kinase Kinases, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Adaptor Proteins, Signal Transducing, Mice

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An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

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