The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Chromatin structure analyses identify miRNA promoters
Open accessAbstract
Although microRNAs (miRNAs) are key regulators of gene expression in normal human physiology and disease, transcriptional regulation of miRNAs is poorly understood, because most miRNA promoters have not yet been characterized. We identified the proximal promoters of 175 human miRNAs by combining nucleosome mapping with chromatin signatures for promoters. We observe that one-third of intronic miRNAs have transcription initiation regions independent from their host promoters and present a list of RNA polymerase II- and III-occupied miRNAs. Nucleosome mapping and linker sequence analyses in miRNA promoters permitted accurate prediction of transcription factors regulating miRNA expression, thus identifying nine miRNAs regulated by the MITF transcription factor/oncoprotein in melanoma cells. Furthermore, DNA sequences encoding mature miRNAs were found to be preferentially occupied by positioned-nucleosomes, and the 3′ end sites of known genes exhibited nucleosome depletion. The high-throughput identification of miRNA promoter and enhancer regulatory elements sheds light on evolution of miRNA transcription and permits rapid identification of transcriptional networks of miRNAs.
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Cites
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<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
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“lutionary conservation scores (Siepel et al. 2005) (C) are shown at miRNA promoters.”
BackgroundA Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
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Cited by
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
The widespread regulation of microRNA biogenesis, function and decay
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Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
RNA sequencing: advances, challenges and opportunities
Ozsolak, F., & Milos, P. M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2934 · Cited by 2,135
Self-citationEpigenetics and gene expression
Gibney, E. R., & Nolan, C. M. (2010) · Heredity · doi:10.1038/hdy.2010.54 · Cited by 1,109
Metadata
- Authors
- Ozsolak, F., Poling, L. L., Wang, Z., Liu, H., Liu, X. S., Roeder, R. G., Zhang, X., Song, J. S., & Fisher, D. E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-11-15
- Volume
- 22
- Issue
- 22
- Pages
- 3172-3183
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2041825143
- Cited by
- 678
- References
- 14
- Type
- posted content
- Language
- en
- Open access
- diamond
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