The genomic landscapes of inflammation
Open accessAbstract
Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.
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In myeloid, dendritic, and B lineage cells, PU.1 is a major contributor to positive regulation of genes that establish lineage-specific identity.
“In myeloid, dendritic, and B lineage cells, PU.1 is a major contributor to the positive regulation of genes that establish lineage-specific identity (4, 17, 19).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [17]
The section “The cis-regulatory repertoire of professional inflammatory cells” describes PU.1 as a lineage-determining factor that activates macrophage-specific enhancers and notes a distinct pattern of PU.1 binding in B cells. It does not establish the claimed positive regulation of lineage-identity genes across myeloid, dendritic, and B lineage cells; the evidence it discusses concerns enhancers, and it does not substantiate the dendritic-cell portion. (LLM, conf=0.84)
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- Authors
- Natoli, G., Ghisletti, S., & Barozzi, I.
- Affiliations
- European Institute of Oncology (IT)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-01-15
- Volume
- 25
- Issue
- 2
- Pages
- 101-106
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3022255
- OpenAlex
- W2005656449
- Cited by
- 152
- References
- 37
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 15 · 2012: 10
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inflammation, transcriptional programs, transcription factors, enhancers, PU.1, macrophage differentiation, NF-kB, AP-1, interferon regulatory factors, cell type specificity
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Inflammation, Macrophages, Transcription Factors, Genome
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