PreprintCited by 828Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.·2013·Genes & Development

DOI 10.1101/gad.211649.112PMC PMC3576510

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Abstract

One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.

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Background
Wnt inhibition enhances browning of mouse primary white adipocytes
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Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health
Sakellariou, P., Valente, A., Carrillo, A. E., Metsios, G. S., Nadolnik, L. I., Jamurtas, A. Z., Koutedakis, Y., Boguszewski, C. L., Andrade, C. M. B., Svensson, P., et al. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.05.006 · Cited by 31
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Brown and beige adipose tissue: New therapeutic targets for metabolic disorders
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Authors: Wu, J., Cohen, P., & Spiegelman, B. M.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
ORCID: Wu, Jun
Cohen, Paul
Spiegelman, Bruce M.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2013-02-01
Volume: 27
Issue: 3
Pages: 234-250
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.211649.112
PMC: PMC3576510
OpenAlex: W2170874580
Cited by: 828
References: 204
Citations by year: 2026: 22 · 2025: 29 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 64 · 2020: 64 · 2019: 72 · 2018: 56 · 2017: 91 · 2016: 73 · 2015: 98 · 2014: 91 · 2013: 46
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: Foundation for the National Institutes of Health
American Heart Association
JPB Foundation
National Institutes of Health (DK31405)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031405, DK-31405, K01DK094824, RC4DK090861, DK90861, R37DK031405)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: beige adipocytes, brown adipose tissue, thermogenesis, energy expenditure, adaptive thermogenesis, obesity, diabetes mellitus, metabolic disorders, adipogenesis
MeSH terms: Uncoupling Protein 1, Adaptation, Physiological, Animals, Adipose Tissue, Brown, Humans, Ion Channels, Obesity, Adipocytes, Gene Expression Regulation, Developmental, Thermogenesis, Mitochondrial Proteins

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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