The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Adaptive thermogenesis in adipocytes: Is beige the new brown?
Open accessAbstract
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.
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“Brite adipocytes can express UCP1 and, as such, can participate in the maintenance of body temperature 90.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [90]
In the citing paper
“This process is characterized by the appearance of brite (from brown‐in‐white) adipocytes, also called beige adipocytes, mainly in subcutaneous WAT.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [90]
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2 retracted
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Self-citationIdentification and Importance of Brown Adipose Tissue in Adult Humans
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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
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Self-citationCold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
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Self-citationFunctional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
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Items 801–827 of 827
Szeder, B. (2023) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2022.152
Piezo2 in sensory neurons influences systemic and adipose tissue metabolismPreprint
Passini, F. S., Bornstein, B., Rubin, S., Kuperman, Y., Krief, S., Masschelein, E., Mehlman, T., Brandis, A. S., Addadi, Y., Shalom, S. H.-O., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.27.624676
Sari-Saraf, V., Khani, M., & Saghi, M. (2025) · Iṭṭilā’āt-i māhiyānah. · doi:10.61186/nsft.20.1.1
Adipose tissue: A target for prevention and treatment of metabolic diseases
Souza‐Mello, V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27370-4.00003-2
Obesity/Perinatal Origins of Obesity
Kwok, T. C., Ojha, S., & Symonds, M. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-443-23940-3.00041-7
Brown adipocytes from pluripotent stem cells: a promising therapy for obesity
Ha, M., Leng, T., Jiang, J., Ma, X., Chen, Y., Hu, T., Huang, Y., & Rao, C. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11281-w
“This is evidenced by their ability to transition from a “white” phenotype, characterized by the storage of large lipid droplets as single entities, to a “brown” phenotype, which involves multiple lipid droplets associated with energy dissipation and uncoupled mitochondrial respiration [ 48].”
Shen, X., Haruyama, M., Murano, S., & Kaburagi, T. (2025) · Nutraceuticals · doi:10.3390/nutraceuticals5040039
Genetic foundation of brown adipose tissue and its role in childhood obesity
Maksimović, N., Perović, D., Perović, V., Pjević, M. D., & Grk, M. (2025) · Medicinska istrazivanja · doi:10.5937/medi0-58230
Ma, Y., Zhang, Z., Ramos, E. T., Martin, E., Gunukula, R., Sprabary, K., & Jun, H. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01946-8
“Beige adipocytes emerge through a process known as “ beiging ” or “ browning ” in response to various stimuli, such as cold temperature [12].”
Mooli, R. G. R., Ramakrishnan, S. K., & Kershaw, E. E. (2026) · Springer eBooks · doi:10.1007/978-3-031-96019-2_25
Salmón‐Gómez, L., Gómez‐Ambrosi, J., Frühbeck, G., & Catalán, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00346-0
Salehi, M., Shahanipour, K., Monajemi, R., & Mohamadynejad, P. (2026) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr-162445
“Previous studies suggest that brown fat is ideal for treating obesity due to its efficient fat burning and energy usage (37, 38).”
Direct Measurement of Adipose Thermogenesis by Isothermal Microcalorimetry
Schots, P. C., Kesharwani, D., Doucette, C. C., & Brown, A. C. (2026) · Cells · doi:10.3390/cells15070579 · Cited by 1
“Thermogenic adipocytes, including brown adipocytes and inducible beige adipocytes within white adipose tissue, dissipate chemical energy as heat and play a critical role in metabolic regulation [6–8].”
Tissu adipeux ectopique et pathologie cardiaque
Gaborit, B. (2013) · theses.fr (ABES) · doi:10.70675/950549dfzb0e2z4faaz9e53z9e9fd1812f11
Derhourhi, M. (2018) · theses.fr (ABES) · doi:10.70675/2d396fe9z564dz48a1z89b4z746f99df764e
Implications du microbiote intestinal et de la pectine dans la stéato-hépatite non-alcoolique
Houron, C. (2020) · theses.fr (ABES) · doi:10.70675/282e9d85z4f3dz4f5bz9045zd1ce6da72037
Métabolisme redox et plasticité tissulaire des tissus adipeux
Jeanson, Y. (2015) · theses.fr (ABES) · doi:10.70675/0a5580f9z0185z4ab1zba28zb59c62a27680
C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice
Zhao, L., Han, J., Wang, X., Li, Q., Shi, Q., Tao, F. B., Li, P., Zhang, C., Liu, Q., & Zhang, J. Y. (2026) · Nature Communications · doi:10.1038/s41467-026-73368-7
“Mammals have two types of thermogenic adipocytes: brown adipocytes and beige adipocytes 48,49 .”
GDF-11 triggers cold-induced browning and metabolic activation of adipose tissue
Sagliocchi, S., Acampora, L., Miro, C., Nappi, A., Restolfer, F., Dentice, M., & Cicatiello, A. G. (2026) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2026-0087
“This process, termed “ beiging ” or “ browning, ” is characterized by the upregulation of thermogenic genes such as Cidea (Cell death-inducing DFFA-like e ff ector a) and Dio2 (Deiodinase 2) [3, 4].”
Past, present, and future of thermogenic fat research: A bibliometric analysis from 2000 to 2023
Xie, H., Chen, L., Long, B., Song, X., Jiang, M., & Song, Z. (2026) · Medicine · doi:10.1097/md.0000000000049210
“[23,25,28,32,33] 39] Citation bursts refer to frequently cited references within a specific period, and the popularity of a particular topic within a certain time frame can be discovered through citation burst detection.”
Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis
Nie, T., Chen, J., Wang, Z., & Mao, L. (2026) · PPAR Research · doi:10.1155/ppar/1742256
Toxic crossroads: environmental pesticides and their endocrine footprints in global metabolic health
Onikanni, S. A., Murucci, M. D., da Costa, T. G., Amos, O. E., Ajayi, O. D., Dao, T., Ajiboye, B. O., Adewole, E., Piperni, S. G., & Miranda‐Alves, L. (2026) · Journal of Molecular Endocrinology · doi:10.1530/jme-25-0183
Experimental Models of Weight Cycling: A Narrative Review of Protocol Design and Metabolic Outcomes
Vasques‐Monteiro, I. M. L., Miranda, C. S., Mucci, D. D. B., Saguie, B. O., Simões, R. L., Martins, F. F., Souza‐Mello, V., & Abdalla, D. S. P. (2026) · Journal of Obesity · doi:10.1155/jobe/2128461
“Unlike white adipocytes, which store extra energy as triacylglycerol (TAG), classic beige and brown adipocytes are distinguished by their unique ability to dissipate mitochondrial energy as heat via uncoupling protein 1 (UCP1) [43, 44].”
Metadata
- Authors
- Wu, J., Cohen, P., & Spiegelman, B. M.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-01
- Volume
- 27
- Issue
- 3
- Pages
- 234-250
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3576510
- OpenAlex
- W2170874580
- Cited by
- 828
- References
- 204
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 64 · 2020: 64 · 2019: 72 · 2018: 56 · 2017: 91 · 2016: 73 · 2015: 98 · 2014: 91 · 2013: 46
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Foundation for the National Institutes of Health
- American Heart Association
- JPB Foundation
- National Institutes of Health (DK31405)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031405, DK-31405, K01DK094824, RC4DK090861, DK90861, R37DK031405)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- beige adipocytes, brown adipose tissue, thermogenesis, energy expenditure, adaptive thermogenesis, obesity, diabetes mellitus, metabolic disorders, adipogenesis
- MeSH terms
- Uncoupling Protein 1, Adaptation, Physiological, Animals, Adipose Tissue, Brown, Humans, Ion Channels, Obesity, Adipocytes, Gene Expression Regulation, Developmental, Thermogenesis, Mitochondrial Proteins
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