PreprintCited by 828Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.·2013·Genes & Development

DOI 10.1101/gad.211649.112PMC PMC3576510

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Abstract

One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.

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Background
Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease
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“In addition, the presence of BRITE (BRown in whITE) adipose tissue in adults has been identified, also derived from Myf5- MSCs which can convert into WAT or BAT depending on the circumstances (48).”
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A pilot study of FDG PET/CT detects a link between brown adipose tissue and breast cancer
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Combination of Capsaicin and Capsiate Induces Browning in 3T3-L1 White Adipocytes via Activation of the Peroxisome Proliferator-Activated Receptor γ/β3-Adrenergic Receptor Signaling Pathways
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“Beige/brite adipose tissue is observed when brown-like adipocytes are found within white adipose tissue, thought to be in response to cold challenge [72,75,76] or activation of sympathetic adrenergic receptors on adipocytes [77].”
Background
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Background
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Background
Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue
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Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice
Grefhorst, A., van den Beukel, J. C., van Houten, E. L. A. F., Steenbergen, J., Visser, J. A., & Themmen, A. P. N. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0025-y · Cited by 54
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Background
The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice
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“induced obesity can also be obtained by transgenic expression of UCP1 itself 36 or by modulation of several key molecules involved in brown adipocyte differentiation.(37) For instance, the lean phenotype of mice lacking NRIP1 is accompanied by increased Ucp1 expression in white adipose tissue.”
Background
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Peppler, W. T., Townsend, L. K., Knuth, C. M., Foster, M. T., & Wright, D. C. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00226.2017 · Cited by 52
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Background
Regulation of immunometabolism in adipose tissue
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Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice
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Background
Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway
Kajimura, S. (2015) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2015.4 · Cited by 52
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ASK1 inhibits browning of white adipose tissue in obesity
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BackgroundMethodInfluential
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Background
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BackgroundInfluential
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Authors: Wu, J., Cohen, P., & Spiegelman, B. M.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
ORCID: Wu, Jun
Cohen, Paul
Spiegelman, Bruce M.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2013-02-01
Volume: 27
Issue: 3
Pages: 234-250
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.211649.112
PMC: PMC3576510
OpenAlex: W2170874580
Cited by: 828
References: 204
Citations by year: 2026: 22 · 2025: 29 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 64 · 2020: 64 · 2019: 72 · 2018: 56 · 2017: 91 · 2016: 73 · 2015: 98 · 2014: 91 · 2013: 46
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: Foundation for the National Institutes of Health
American Heart Association
JPB Foundation
National Institutes of Health (DK31405)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031405, DK-31405, K01DK094824, RC4DK090861, DK90861, R37DK031405)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: beige adipocytes, brown adipose tissue, thermogenesis, energy expenditure, adaptive thermogenesis, obesity, diabetes mellitus, metabolic disorders, adipogenesis
MeSH terms: Uncoupling Protein 1, Adaptation, Physiological, Animals, Adipose Tissue, Brown, Humans, Ion Channels, Obesity, Adipocytes, Gene Expression Regulation, Developmental, Thermogenesis, Mitochondrial Proteins

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Adaptive thermogenesis in adipocytes: Is beige the new brown?

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