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Adaptive thermogenesis in adipocytes: Is beige the new brown?
Open accessAbstract
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.
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“Brite adipocytes can express UCP1 and, as such, can participate in the maintenance of body temperature 90.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [90]
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“This process is characterized by the appearance of brite (from brown‐in‐white) adipocytes, also called beige adipocytes, mainly in subcutaneous WAT.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [90]
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“Brown adipocytes, which can also develop in WAT in a process referred to as ‘‘beiging’’ of WAT (Wu et al., 2012a, 2013) contain numerous small lipid vacuoles surrounded by numerous well-developed mitochondria (Lim et al., 2012), which contain iron pigmented-cytochromes that are largely responsible…”
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The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
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Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis
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Metadata
- Authors
- Wu, J., Cohen, P., & Spiegelman, B. M.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-01
- Volume
- 27
- Issue
- 3
- Pages
- 234-250
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3576510
- OpenAlex
- W2170874580
- Cited by
- 828
- References
- 204
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 34 · 2023: 37 · 2022: 46 · 2021: 64 · 2020: 64 · 2019: 72 · 2018: 56 · 2017: 91 · 2016: 73 · 2015: 98 · 2014: 91 · 2013: 46
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Foundation for the National Institutes of Health
- American Heart Association
- JPB Foundation
- National Institutes of Health (DK31405)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031405, DK-31405, K01DK094824, RC4DK090861, DK90861, R37DK031405)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- beige adipocytes, brown adipose tissue, thermogenesis, energy expenditure, adaptive thermogenesis, obesity, diabetes mellitus, metabolic disorders, adipogenesis
- MeSH terms
- Uncoupling Protein 1, Adaptation, Physiological, Animals, Adipose Tissue, Brown, Humans, Ion Channels, Obesity, Adipocytes, Gene Expression Regulation, Developmental, Thermogenesis, Mitochondrial Proteins
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