Cited by 75Circadian rhythm and melatoninMetabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and GL expression

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Zani, Fabio, Breasson, Ludovic, Becattini, Barbara, Vukolic, Ana, Montani, Jean-Pierre, Albrecht, Urs, Provenzani, Alessandro, Ripperger, Juergen A. +1 more·2013·Molecular Metabolism

Abstract

The interplay between hepatic glycogen metabolism and blood glucose levels is a paradigm of the rhythmic nature of metabolic homeostasis. Here we show that mice lacking a functional PER2 protein (Per2 (Brdm1) ) display reduced fasting glycemia, altered rhythms of hepatic glycogen accumulation, and altered rhythms of food intake. Per2 (Brdm1) mice show reduced hepatic glycogen content and altered circadian expression during controlled fasting and refeeding. Livers from Per2 (Brdm1) mice display reduced glycogen synthase protein levels during refeeding, and increased glycogen phosphorylase activity during fasting. The latter is explained by PER2 action on the expression of the adapter proteins PTG and GL, which target the protein phosphatase-1 to glycogen to decrease glycogen phosphorylase activity. Finally, PER2 interacts with genomic regions of Gys2, PTG, and G L . These results indicate an important role for PER2 in the hepatic transcriptional response to feeding and acute fasting that promotes glucose storage to liver glycogen.

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Crossref · 10.1016/j.molmet.2013.06.006

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  • Per2 mutant mice show reduced fasting glycemia, loss of rhythmic glycogen accumulation in the liver, elevated plasma insulin levels and impaired gluconeogenesis.

    “Per2 mutant mice show reduced fasting glycemia, a loss of rhythmic glycogen accumulation in the liver, elevated plasma insulin levels and impaired gluconeogenesis [20–22]”

    From Circadian control of glucose metabolism (2014) · cites this paper as [21]

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Authors
Zani, F., Breasson, L., Becattini, B., Vukolic, A., Montani, J.-P., Albrecht, U., Provenzani, A., Ripperger, J. A., & Solinas, G.
Affiliations
  • University of Fribourg (CH)
  • University of Trento (IT)
Corresponding author
Solinas, Giovanni
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2013-08
Volume
2
Issue
3
Pages
292-305
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2014234042
Cited by
75
References
35
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 9 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 10 · 2015: 11 · 2014: 2
FWCI
4.13
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Trento) (submittedVersion, cc-by-nc-nd)
Funders
Swiss National Science Foundation (31003A-118172, 31003A_135684)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Keywords
Per2, liver glycogen, glycogen synthase, glycogen phosphorylase, GL, protein phosphatase 1, circadian clock, fasting, refeeding, glucose storage, circadian gene expression

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