Relaxation of selective constraint on dog mitochondrial DNA following domestication
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The domestication of dogs caused a dramatic change in their way of life compared with that of their ancestor, the gray wolf. We hypothesize that this new life style changed the selective forces that acted upon the species, which in turn had an effect on the dog's genome. We sequenced the complete mitochondrial DNA genome in 14 dogs, six wolves, and three coyotes. Here we show that dogs have accumulated nonsynonymous changes in mitochondrial genes at a faster rate than wolves, leading to elevated levels of variation in their proteins. This suggests that a major consequence of domestication in dogs was a general relaxation of selective constraint on their mitochondrial genome. If this change also affected other parts of the dog genome, it could have facilitated the generation of novel functional genetic diversity. This diversity could thus have contributed raw material upon which artificial selection has shaped modern breeds and may therefore be an important source of the extreme phenotypic variation present in modern-day dogs.
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There is a higher frequency of non-synonymous substitutions in the mitochondrial DNA of domesticated dogs relative to gray wolves.
“and the same is true of their mitochondrial DNA [130]”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [130]
A build-up of deleterious alleles is documented across domesticated species when compared to their wild counterparts.
“A build-up of deleterious alleles is documented across domesticated species when compared to their wild counterparts.”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [130]
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP
Felsenstein, J. (1985) · Evolution · doi:10.1111/j.1558-5646.1985.tb00420.x · Cited by 44,735 · see citing works
MRBAYES: Bayesian inference of phylogenetic trees.
Huelsenbeck, J. P., & Ronquist, F. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.8.754 · Cited by 21,937 · see citing works
MODELTEST: testing the model of DNA substitution.
Posada, D., & Crandall, K. A. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.9.817 · Cited by 19,820 · see citing works
Confidence Limits on Phylogenies: An Approach Using the Bootstrap
Felsenstein, J. (1985) · Evolution · doi:10.2307/2408678 · Cited by 19,371 · see citing works
PAUP^* : Phylogenetic Analysis Using Parsimony (and other methods) 4.0b8
Swofford, D. L. (2001) · Cited by 12,789 · see citing works
Dating of the human–ape splitting by a molecular clock of mitochondrial DNA.
Hasegawa, M., Kishino, H., & Yano, T.-A. (1985) · Journal of Molecular Evolution · doi:10.1007/bf02101694 · Cited by 8,687 · see citing works
Molecular Evolution and Phylogenetics
Nei, M., & Kumar, S. (2000) · doi:10.1093/oso/9780195135848.001.0001 · Cited by 8,012 · see citing works
On the Origin of Species by Means of Natural Selection
Livezey, R. L., & Darwin, C. R. (1953) · The American Midland Naturalist · doi:10.2307/2485224 · Cited by 5,430 · see citing works
PAML: a program package for phylogenetic analysis by maximum likelihood
Yang, Z. (1997) · Computer applications in the biosciences · doi:10.1093/bioinformatics/13.5.555 · Cited by 5,344 · see citing works
MRBAYES: Bayesian inference of phylogeny
Huelsenbeck, J. P., & Ronquist, F. (2001) · Bioinformatics · Cited by 4,892 · see citing works
A codon-based model of nucleotide substitution for protein-coding DNA sequences.
(1994) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040153 · Cited by 1,960 · see citing works
Mitochondrial genome variation and the origin of modern humans
Ingman, M., Kaessmann, H., Pääbo, S., & Gyllensten, U. B. (2000) · Nature · doi:10.1038/35047064 · Cited by 1,532 · see citing works
Multiple and Ancient Origins of the Domestic Dog
Vilà, C., Savolainen, P., Maldonado, J. E., Amorim, I. R., Rice, J. E., Honeycutt, R. L., Crandall, K. A., Lundeberg, J., & Wayne, R. K. (1997) · Science · doi:10.1126/science.276.5319.1687 · Cited by 1,091 · see citing works
Genetic Evidence for an East Asian Origin of Domestic Dogs
Savolainen, P., Zhang, Y.-P., Luo, J., Lundeberg, J., & Leitner, T. (2002) · Science · doi:10.1126/science.1073906 · Cited by 960 · see citing works
Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA
Ruiz‐Pesini, E., Mishmar, D., Brandon, M., Procaccio, V., & Wallace, D. C. (2004) · Science · doi:10.1126/science.1088434 · Cited by 806 · see citing works
Positive and Negative Selection on the Human Genome
Fay, J. C., Wyckoff, G. J., & Wu, C. (2001) · Genetics · doi:10.1093/genetics/158.3.1227 · Cited by 646 · see citing works
Molecular origins of rapid and continuous morphological evolution
Fondon, J. W., & Garner, H. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408118101 · Cited by 614 · see citing works
The Role of Selection in the Evolution of Human Mitochondrial Genomes
Kivisild, T., Shen, P., Wall, D. P., Do, B. H., Sung, R., Davis, K., Passarino, G., Underhill, P. A., Scharfe, C., Torroni, A., et al. (2005) · Genetics · doi:10.1534/genetics.105.043901 · Cited by 457 · see citing works
Genetic Structure of the Purebred Domestic Dog
Parker, H., Kim, L., Sutter, N., Carlson, S., Lorentzen, T. D., Malek, T. B., Johnson, G. S., DeFrance, H. B., Ostrander, E., & Kruglyak, L. (2004) · Science · doi:10.1126/science.1097406 · Cited by 405 · see citing works
Mitochondrial DNA phylogeography and population history of the grey wolfCanis lupus
Vilà, C., Amorim, I. R., Leonard, J. A., Posada, D., Castroviejo, J., Petrucci‐Fonseca, F., Crandall, K. A., Ellegren, H., & Wayne, R. K. (1999) · Molecular Ecology · doi:10.1046/j.1365-294x.1999.00825.x · Cited by 368 · see citing works
Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes
Zhang, J. (2000) · Journal of Molecular Evolution · doi:10.1007/s002399910007 · Cited by 356 · see citing works
The Probability of Fixation in Populations of Changing Size
Otto, S. P., & Whitlock, M. C. (1997) · Genetics · doi:10.1093/genetics/146.2.723 · Cited by 341 · see citing works
Generation Time and Genomic Evolution in Primates
Sarich, V. M., & Wilson, A. C. (1973) · Science · doi:10.1126/science.179.4078.1144 · Cited by 327 · see citing works
On the constancy of the evolutionary rate of cistrons
Ohta, T., & Kimura, M. (1971) · Journal of Molecular Evolution · doi:10.1007/bf01659391 · Cited by 322 · see citing works
Dog star rising: the canine genetic system
Sutter, N. B., & Ostrander, E. A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1492 · Cited by 259 · see citing works
The Earliest Ice Age Dogs: Evidence from Eliseevichi 1
Sablin, M., & Khlopachev, G. (2002) · Current Anthropology · doi:10.1086/344372 · Cited by 209 · see citing works
Unleashing the Canine GenomePreprint
Ostrander, E. A., & Kruglyak, L. (2000) · Genome Research · doi:10.1101/gr.155900 · Cited by 165 · see citing works
Hasegawa, M., Cao, Y., & Yang, Z. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025877 · Cited by 159 · see citing works
Genes of domestic mammals augmented by backcrossing with wild ancestors
Vilà, C., Seddon, J. M., & Ellegren, H. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.02.004 · Cited by 153 · see citing works
From wild wolf to domestic dog: gene expression changes in the brain
Saetre, P., Lindberg, J. H., Leonard, J. A., Olsson, K., Pettersson, U., Ellegren, H., Bergström, T. F., Vilà, C., & JAZIN, E. E. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.003 · Cited by 150 · see citing works
Hoelzel, A. R., Lopez, J. V., Dover, G. A., & O’Brien, S. J. (1994) · Journal of Molecular Evolution · doi:10.1007/bf00163807 · Cited by 134 · see citing works
Short interspersed elements (SINEs) are a major source of canine genomic diversityPreprint
Wang, W., & Kirkness, E. F. (2005) · Genome Research · doi:10.1101/gr.3765505 · Cited by 125 · see citing works
Piganeau, G., & Eyre‐Walker, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1833064100 · Cited by 90 · see citing works
Consequences of domestication: morphological diversity of the dog.
Wayne, R. K. (2001) · CABI Publishing eBooks · doi:10.1079/9780851995205.0043 · Cited by 34 · see citing works
Khan (2000) · doi:10.1002/1531-8249(200008)48:2
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Coppinger, R. and Coppinger, L. 2001. Dogs. The University of Chicago Press, Chicago.
Cited by
Sorted by citations
The Evolution of Animal Domestication
Larson, G., & Fuller, D. Q. (2014) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-110512-135813 · Cited by 640 · see citing works
Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs
Thalmann, O., Shapiro, B., Cui, P., Schuenemann, V. J., Sawyer, S., Greenfield, D., Germonpré, M., Sablin, M., López‐Giráldez, F., Domingo‐Roura, X., et al. (2013) · Science · doi:10.1126/science.1243650 · Cited by 528 · see citing works
Large‐Scale Diversification of Skull Shape in Domestic Dogs: Disparity and Modularity
Drake, A. G., & Klingenberg, C. P. (2010) · The American Naturalist · doi:10.1086/650372 · Cited by 429 · see citing works
Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Pielberg, G., Sigurðsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002316 · Cited by 390 · see citing works
Self-citationMarsden, C. D., Ortega-Del Vecchyo, D., O’Brien, D. P., Taylor, J. F., Ramirez, O., Vilà, C., Marques-Bonet, T., Schnabel, R. D., Wayne, R. K., & Lohmueller, K. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512501113 · Cited by 333 · see citing works
Origins and genetic legacy of prehistoric dogs
Bergström, A., Frantz, L., Schmidt, R., Ersmark, E., Lebrasseur, O., Girdland-Flink, L., Lin, A. T., Storå, J., Sjögren, K.-G., Anthony, D., et al. (2020) · Science · doi:10.1126/science.aba9572 · Cited by 297 · see citing works
Genetic structure in village dogs reveals a Central Asian domestication origin
Shannon, L. M., Boyko, R. H., Castelhano, M. G., Corey, E. E., Hayward, J. J., McLean, C., White, M. E., Said, M. A., Anita, B. A., Ikombe, N. B., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516215112 · Cited by 229 · see citing works
Man's Best Friend Becomes Biology's Best in Show: Genome Analyses in the Domestic Dog
Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-115200 · Cited by 220 · see citing works
Lessons learned from the dog genome
Wayne, R. K., & Ostrander, E. A. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.08.013 · Cited by 206 · see citing works
The evolutionary history of dogs in the Americas
Leathlobhair, M. N., Perri, A. R., Irving-Pease, E. K., Witt, K. E., Linderholm, A. E., Haile, J., Lebrasseur, O., Ameen, C., Blick, J. P., Boyko, A. R., et al. (2018) · Science · doi:10.1126/science.aao4776 · Cited by 197 · see citing works
Shen, Y., Shi, P., Sun, Y., & Zhang, Y. (2009) · Genome Research · doi:10.1101/gr.093138.109 · Cited by 201 · see citing works
Hindrikson, M., Remm, J., Pilot, M., Godinho, R., Strønen, A. V., Baltrūnaitė, L., Czarnomska, S. D., Leonard, J. A., Randi, E., Nowak, C., et al. (2016) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12298 · Cited by 196 · see citing works
Boyko, A. R., Boyko, R. H., Boyko, C. M., Parker, H. G., Castelhano, M., Corey, L., Degenhardt, J. D., Auton, A., Hedimbi, M., Kityo, R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902129106 · Cited by 182 · see citing works
Lv, F., Peng, W., Yang, J. H., Zhao, Y., Li, W., Liu, M., Ma, Y., Zhao, Q., Yang, G., Wang, F., et al. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv139 · Cited by 184 · see citing works
Grey wolf genomic history reveals a dual ancestry of dogs
Bergström, A., Stanton, D. W. G., Taron, U. H., Frantz, L., Sinding, M. S., Ersmark, E., Pfrengle, S., Cassatt‐Johnstone, M., Lebrasseur, O., Girdland-Flink, L., et al. (2022) · Nature · doi:10.1038/s41586-022-04824-9 · Cited by 187 · see citing works
Self-domestication in Homo sapiens: Insights from comparative genomics
Theofanopoulou, C., Gastaldon, S., O’Rourke, T., Samuels, B. D., Messner, A., Martins, P. T., Delogu, F., Alamri, S., & Boeckx, C. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185306 · Cited by 174 · see citing works
Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number
Wachsmuth, M., Hübner, A., Li, M., Madea, B., & Stoneking, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005939 · Cited by 164 · see citing works
The legacy of domestication: accumulation of deleterious mutations in the dog genome
Cruz, F., Vila, C., & Webster, M. T. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn177 · Cited by 154 · see citing works
Ji, R., Cui, P., Ding, F. H., Geng, J., Gao, H., Zhang, H., YU, J., Hu, S., & Meng, H. (2009) · Animal Genetics · doi:10.1111/j.1365-2052.2008.01848.x · Cited by 129 · see citing works
The domestic dog: man's best friend in the genomic era
Boyko, A. R. (2011) · Genome biology · doi:10.1186/gb-2011-12-2-216 · Cited by 122 · see citing works
Domestication Genomics: Evidence from Animals
Wang, G., Xie, H., Peng, M., Irwin, D. M., & Zhang, Y. (2013) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022513-114129 · Cited by 117 · see citing works
Origin of mitochondrial DNA diversity of domestic yaks
Guo, S., Savolainen, P., Su, J., Zhang, Q., Qi, D., Zhou, J., Zhong, Y., Zhao, X., & Liu, J. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-73 · Cited by 116 · see citing works
Domestication and plant genomes
Tang, H., Sezen, U. U., & Paterson, A. H. (2009) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2009.10.008 · Cited by 116 · see citing works
Yuan, Q., Zhang, Z.-Y., Hu, J., Guo, L.-P., Shao, A.-J., & Huang, L.-Q. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-29 · Cited by 114 · see citing works
Zhang, Y., Sun, J., Rouse, G. W., Wiklund, H., Pleijel, F., Watanabe, H., Chen, C., Qian, P., & Qiu, J. (2018) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2018.04.002 · Cited by 114 · see citing works
Molecular evolution of the antiretroviral TRIM5 gene
Johnson, W. E., & Sawyer, S. L. (2009) · Immunogenetics · doi:10.1007/s00251-009-0358-y · Cited by 114 · see citing works
Elevated Proportions of Deleterious Genetic Variation in Domestic Animals and Plants
Makino, T. T., Rubin, C., Carneiro, M., Axelsson, E., Andersson, L., & Webster, M. T. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy004 · Cited by 113 · see citing works
Werhahn, G., Senn, H., Ghazālī, M., Karmacharya, D. B., Sherchan, A. M., Joshi, J., Kusi, N., López‐Bao, J. V., Rosen, T., Kachel, S. M., et al. (2018) · Global Ecology and Conservation · doi:10.1016/j.gecco.2018.e00455 · Cited by 109 · see citing works
Hindrikson, M., Männil, P., Ozoliņš, J., Krzywiński, A., & Saarma, U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046465 · Cited by 110 · see citing works
Domestication relaxed selective constraints on the yak mitochondrial genome
Wang, Z., Yonezawa, T., Liu, B., Ma, T., Shen, X., Su, J., Guo, S., Hasegawa, M., & Liu, J. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq336 · Cited by 98 · see citing works
“In accordance with previous studies of other animals (Björnerfeldt et al. 2006), our study suggests that the evolution of yak mtDNA has been significantly 1555Downloaded from https://academic.oup.com/mbe/article-abstract/28/5/1553/1268305 by guest on 27 July 2018 modified following domestication,…”
BackgroundResultInfluentialWang, M.-S., Zhang, R.-W., Su, L.-Y., Li, Y., Peng, M.-S., Liu, H.-Q., Zeng, L., Irwin, D. M., Du, J.-L., Yao, Y.-G., et al. (2016) · Cell Research · doi:10.1038/cr.2016.44 · Cited by 85 · see citing works
Nabholz, B., Sarah, G., Sabot, F., Ruíz, M., Adam, H., Nidelet, S., Ghesquière, A., Santoni, S., David, J., & Glémin, S. (2014) · Molecular Ecology · doi:10.1111/mec.12738 · Cited by 85 · see citing works
Forty-two Thousand and One Dalmatians: Fads, Social Contagion, and Dog Breed Popularity
Herzog, H. (2006) · Society and Animals · doi:10.1163/156853006778882448 · Cited by 83 · see citing works
Cui, P., Ji, R., Ding, F. H., Qi, D., Gao, H., Meng, H., Yu, J. M., Hu, S., & Zhang, H. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-241 · Cited by 82 · see citing works
Koblmüller, S., Vilà, C., Lorente-Galdós, B., Dabad, M., Ramírez, Ó., Marquès‐Bonet, T., Wayne, R. K., & Leonard, J. A. (2016) · Journal of Biogeography · doi:10.1111/jbi.12765 · Cited by 76 · see citing works
The genetic legacy of extirpation and re-colonization in Vancouver Island wolves
Muñoz‐Fuentes, V., Darimont, C. T., Paquet, P. C., & Leonard, J. A. (2009) · Conservation Genetics · doi:10.1007/s10592-009-9974-1 · Cited by 74 · see citing works
Nabholz, B., Uwimana, N., & Lartillot, N. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt083 · Cited by 69 · see citing works
Nomura, K., Yonezawa, T., Mano, S., Kawakami, S., Shedlock, A. M., Hasegawa, M., & Amano, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067775 · Cited by 69 · see citing works
Muñoz‐Fuentes, V., Rienzo, A. D., & Vilà, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025498 · Cited by 66 · see citing works
Paleogenomic Inferences of Dog Domestication
Thalmann, O., & Perri, A. R. (2018) · Population genomics · doi:10.1007/13836_2018_27 · Cited by 63 · see citing works
Darwinism for the Genomic Age: Connecting Mutation to Diversification
Hua, X., & Bromham, L. D. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00012 · Cited by 62 · see citing works
The seminiferous epithelium cycle and its duration in different breeds of dog ( Canis familiaris )
Soares, J. M., de Avelar, G. F., & França, L. R. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2009.01122.x · Cited by 61 · see citing works
Maladaptation in feral and domesticated animals
Gering, E., Incorvaia, D. C., Henriksen, R., Wright, D., & Getty, T. (2019) · Evolutionary Applications · doi:10.1111/eva.12784 · Cited by 59 · see citing works
Evaluating Purifying Selection in the Mitochondrial DNA of Various Mammalian Species
Soares, P. A., Abrantes, D., Rito, T., Thomson, N., Predrag Radivojac, A., Li, B., Macaulay, V. A., Samuels, D. C., & Pereira, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058993 · Cited by 55 · see citing works
A range-wide synthesis and timeline for phylogeographic events in the red fox (Vulpes vulpes)
Kutschera, V. E., Lecomte, N., Janke, A., Selva, N., Sokolov, A. A., Haun, T., Steyer, K., Nowak, C., & Hailer, F. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-114 · Cited by 55 · see citing works
Ersmark, E., Klütsch, C. F. C., Chan, Y. L., Sinding, M. S., Fain, S. R., Illarionova, N. A., Oskarsson, M. C. R., Uhlén, M., Zhang, Y., Dalén, L., et al. (2016) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2016.00134 · Cited by 50 · see citing works
Evolutionary History, Selective Sweeps, and Deleterious Variation in the Dog
Freedman, A. H., Lohmueller, K. E., & Wayne, R. K. (2016) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-121415-032155 · Cited by 50 · see citing works
Duleba, A., Skonieczna, K., Bogdanowicz, W., Malyarchuk, B. А., & Grzybowski, T. (2015) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2015.06.014 · Cited by 49 · see citing works
Ki, J., Hwang, D., Park, T.-J., Han, S. H., & Lee, J. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9641-0 · Cited by 49 · see citing works
The Estimation of Tree Posterior Probabilities Using Conditional Clade Probability Distributions
Larget, B. R. (2013) · Systematic Biology · doi:10.1093/sysbio/syt014 · Cited by 48 · see citing works
Osman, S. A. M., Yonezawa, T., & Nishibori, M. (2016) · Poultry Science · doi:10.3382/ps/pew029 · Cited by 48 · see citing works
Going west—invasion genetics of the alien raccoon dog Nyctereutes procynoides in Europe
Pitra, C., Schwarz, S., & Fickel, J. (2009) · European Journal of Wildlife Research · doi:10.1007/s10344-009-0283-2 · Cited by 48 · see citing works
Imes, D. L., Wictum, E. J., Allard, M. W., & Sacks, B. N. (2012) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2012.02.004 · Cited by 46 · see citing works
Zhang, L., Sun, K., Csorba, G., Hughes, A. C., Jin, L., Xiao, Y., & Feng, J. (2021) · BMC Ecology and Evolution · doi:10.1186/s12862-021-01926-2 · Cited by 43 · see citing works
Leite, J. V., Álvares, F., Velo‐Antón, G., Brito, J. C., & Godinho, R. (2015) · Organisms Diversity & Evolution · doi:10.1007/s13127-015-0232-8 · Cited by 40 · see citing works
Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds
Webster, M. T., Kamgari, N., Perloski, M., Hoeppner, M. P., Axelsson, E., Hedhammar, Å. A., Pielberg, G., & Lindblad‐Toh, K. (2015) · BMC Genomics · doi:10.1186/s12864-015-1702-2 · Cited by 41 · see citing works
Cui, P., Liu, H., Lin, Q., Ding, F. H., Zhuo, G., Hu, S., Liu, D., Yang, W., Zhan, K., Zhang, A., et al. (2009) · Journal of Genetics · doi:10.1007/s12041-009-0043-9 · Cited by 40 · see citing works
Kemp, B. M., Judd, K. G., Monroe, C., Eerkens, J. W., Hilldorfer, L., Cordray, C., Schad, R., Reams, E., Ortman, S. G., & Kohler, T. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178882 · Cited by 40 · see citing works
Webb, K. M., & Allard, M. W. (2009) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2008.00952.x · Cited by 39 · see citing works
A 3000 Year Old Dog Burial in Timor-Leste
González, A. U., Clark, G., O’Connor, S., & Matisoo-Smith, L. (2013) · Australian Archaeology · doi:10.1080/03122417.2013.11681961 · Cited by 39 · see citing works
Montana, L., Caniglia, R., Galaverni, M., Fabbri, E., Ahmed, A., Bolfíková, B. Č., Czarnomska, S. D., Galov, A., Godinho, R., Hindrikson, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176560 · Cited by 39 · see citing works
Feline non-repetitive mitochondrial DNA control region database for forensic evidence
Grahn, R. A., Kurushima, J. D., Billings, N. C., Grahn, J. C., Halverson, J. L., Hammer, E., Ho, C., Kun, T. J., Levy, J. K., Lipinski, M. J., et al. (2010) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2010.01.013 · Cited by 38 · see citing works
Axelsson, E., Ljungvall, I., Bhoumik, P., Conn, L. B., Muren, E., Ohlsson, Å., Olsen, L. H., Engdahl, K., Hagman, R., Hanson, J., et al. (2021) · PLOS Genetics · doi:10.1371/journal.pgen.1009726 · Cited by 34 · see citing works
Accumulation of deleterious mutations in the domestic yak genome
Xie, X., Yang, Y. P., Ren, Q., Ding, X., Bao, P., Yan, B., Yan, X., Han, J., Yan, P., & Qiu, Q. (2018) · Animal Genetics · doi:10.1111/age.12703 · Cited by 36 · see citing works
Phylogeography of wolves (Canis lupus) in the Pacific Northwest
Weckworth, B., Talbot, S. L., & Cook, J. A. (2010) · Journal of Mammalogy · doi:10.1644/09-mamm-a-036.1 · Cited by 36 · see citing works
Limited locomotive ability relaxed selective constraints on molluscs mitochondrial genomes
Sun, S., Li, Q., Kong, L., & Yu, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-11117-z · Cited by 35 · see citing works
BaitsTools: Software for hybridization capture bait design
Campana, M. G. (2017) · Molecular Ecology Resources · doi:10.1111/1755-0998.12721 · Cited by 33 · see citing works
Bite force and its relation to jaw shape in domestic dogs
Brassard, C., Merlin, M., Guintard, C., Monchâtre-Leroy, É., Barrat, J., Bausmayer, N., Bausmayer, S., Bausmayer, A., Beyer, M., Varlet, A., et al. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.224352 · Cited by 32 · see citing works
Size Variation under Domestication: Conservatism in the inner ear shape of wolves, dogs and dingoes
Schweizer, A. V., Lebrun, R., Wilson, L. A. B., Costeur, L., Schmelzle, T., & Sánchez-Villagra, M. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-13523-9 · Cited by 32 · see citing works
Rutledge, L. Y., Bos, K. I., Pearce, R. J., & White, B. N. (2009) · Conservation Genetics · doi:10.1007/s10592-009-9957-2 · Cited by 31 · see citing works
Chen, J., Ni, P., Thi, T. N. T., Kamaldinov, E. V., Петухов, В. Л., Han, J., Liu, X., Šprem, N., & Zhao, S. (2018) · Ecology and Evolution · doi:10.1002/ece3.4221 · Cited by 30 · see citing works
Doro, M. G., Piras, D., Leoni, G. G., Casu, G., Vaccargiu, S., Parracciani, D., Naitana, S., Pirastu, M., & Novelletto, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095969 · Cited by 29 · see citing works
Contrast features of CpG islands in the promoter and other regions in the dog genome
Han, L., & Zhao, Z. (2009) · Genomics · doi:10.1016/j.ygeno.2009.04.007 · Cited by 29 · see citing works
The History and Diversity of Rice Domestication as Resolved From 1464 Complete Plastid Genomes
He, W., Chen, C., Xiang, K., Wang, J., Zheng, P., Tembrock, L. R., Jin, D., & Wu, Z. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.781793 · Cited by 28 · see citing works
Rutledge, L. Y., Patterson, B. R., & White, B. N. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-215 · Cited by 26 · see citing works
Axelsson, E., & Ellegren, H. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp019 · Cited by 25 · see citing works
Differences in Selection Drive Olfactory Receptor Genes in Different Directions in Dogs and Wolf
Chen, R., Irwin, D. M., & Zhang, Y. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss153 · Cited by 25 · see citing works
Bednarik, R. G. (2020) · Encyclopedia · doi:10.3390/encyclopedia3030067 · Cited by 25 · see citing works
Zhong, H., Zhang, H., Sha, W., ZHANG, C.-D., & Chen, Y.-C. (2010) · Zoological Research · doi:10.3724/sp.j.1141.2010.02122 · Cited by 24 · see citing works
Wang, Q., Jia, Y., Wang, Y., Jiang, Z., Zhou, X., Zhang, Z., Nie, C., Li, J., Yang, N., & Qu, L. (2019) · BMC Genomics · doi:10.1186/s12864-019-6342-5 · Cited by 23 · see citing works
Origin and phylogenetic analysis of Tibetan Mastiff based on the mitochondrial DNA sequence
Li, Q., Liu, Z., Li, Y., Zhao, X., Dong, L., Pan, Z., Sun, Y., Li, N., Xu, Y., & Xie, Z. (2008) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60049-1 · Cited by 24 · see citing works
Rare and unique adaptations to cancer in domesticated species: An untapped resource?
Frédéric Thomas, A., Giraudeau, M., Dheilly, N. M., Gouzerh, F., Boutry, J., Beckmann, C., Biro, P. A., Hamede, R., Abadie, J., Labrut, S., et al. (2020) · Evolutionary Applications · doi:10.1111/eva.12920 · Cited by 24 · see citing works
Dog mitochondrial genome sequencing to enhance dog mtDNA discrimination power in forensic casework
Verscheure, S., Backeljau, T., & Desmyter, S. (2014) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2014.05.001 · Cited by 21 · see citing works
Population size may shape the accumulation of functional mutations following domestication
Chen, J., Ni, P., Li, X., Han, J., Jakovlić, I., Zhang, C., & Zhao, S. (2018) · BMC Evolutionary Biology · doi:10.1186/s12862-018-1120-6 · Cited by 22 · see citing works
DNA barcoding of three species ( Canis aureus, Canis lupus and Vulpes vulpes ) of Canidae
Aksöyek, E., İbiş, O., Özcan, S., Moradi, M. H., & Tez, C. (2016) · Mitochondrial DNA Part A · doi:10.1080/24701394.2016.1180512 · Cited by 20 · see citing works
Moray, C., Lanfear, R., & Bromham, L. D. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu005 · Cited by 19 · see citing works
Montana, L., Caniglia, R., Galaverni, M., Fabbri, E., & Randi, E. (2017) · Mammalian Biology · doi:10.1016/j.mambio.2017.01.005 · Cited by 19 · see citing works
RabGTD: a comprehensive database of rabbit genome and transcriptome
Zhou, L., Xiao, Q., Bi, J., Wang, Z., & Li, Y. (2018) · Database · doi:10.1093/database/bay075 · Cited by 19 · see citing works
Analysis of structural diversity in wolf-like canids reveals post-domestication variants
Ramírez, Ó., Olalde, Í., Berglund, J., Lorente-Galdós, B., Hernández-Rodríguez, J., Quilez, J., Webster, M. T., Wayne, R. K., Lalueza‐Fox, C., Vilà, C., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-465 · Cited by 18 · see citing works
The selective constraints of ecological specialization in mustelidae on mitochondrial genomes
Wei, Q., Zhang, H., Wu, X., & Sha, W. (2019) · Mammal Research · doi:10.1007/s13364-019-00461-2 · Cited by 17 · see citing works
Ji, Y., Wu, D., Wu, G., Wang, G., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026416 · Cited by 17 · see citing works
Complete mitochondrial genome ofCanis lupus campestris
Zhang, H., Zhang, J., Zhao, C., Chen, L., Sha, W., & Liu, G. (2013) · Mitochondrial DNA · doi:10.3109/19401736.2013.823186 · Cited by 16 · see citing works
Hu, Y., Xing, W., Song, H., Zhu, H., Liu, G., & Hu, Z. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01351 · Cited by 16 · see citing works
Hu, Y., Xing, W., Song, H., Hu, Z., & Liu, G. (2019) · European Journal of Phycology · doi:10.1080/09670262.2019.1663269 · Cited by 16 · see citing works
Ancient DNA from the Asiatic Wild Dog (Cuon alpinus) from Europe
Taron, U. H., Paijmans, J. L. A., Barlow, A., Preick, M., Iyengar, A., Drăgușin, V., Vasile, Ş., Marciszak, A., Roblíčková, M., & Hofreiter, M. (2021) · Genes · doi:10.3390/genes12020144 · Cited by 15 · see citing works
Reviewing population studies for forensic purposes: Dog mitochondrial DNA
Verscheure, S., Backeljau, T., & Desmyter, S. (2013) · ZooKeys · doi:10.3897/zookeys.365.5859 · Cited by 15 · see citing works
Albertson, R. C., & Pauers, M. J. (2018) · Hydrobiologia · doi:10.1007/s10750-018-3829-z · Cited by 15 · see citing works
Wronski, T., & Macasero, W. (2008) · Zoology in the Middle East · doi:10.1080/09397140.2008.10638301 · Cited by 19 · see citing works
Núñez‐León, D., Cordero, G. A., Schlindwein, X., Jensen, P., Stoeckli, E. T., Sánchez-Villagra, M. R., & Werneburg, I. (2021) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2021.0392 · Cited by 14 · see citing works
Salado, I., Preick, M., Lupiáñez-Corpas, N., Fernández‐Gil, A., Vilà, C., Hofreiter, M., & Leonard, J. A. (2022) · Genes · doi:10.3390/genes14010075 · Cited by 14 · see citing works
- Authors
- Björnerfeldt, S., Webster, M. T., & Vilà, C.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Vilà, Carles
- Venue
- Genome Research
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-06-29
- Volume
- 16
- Issue
- 8
- Pages
- 990-994
- ISSN
- 1088-9051 (ISSN-L)
- PMC
- PMC1524871
- OpenAlex
- W2097187579
- Cited by
- 203
- References
- 38
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 2 · 2021: 16 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 9 · 2014: 20 · 2013: 16 · 2012: 6
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genome Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kansas Department of Wildlife and Parks
- Svenska Forskningsrådet Formas
- Vetenskapsrådet
- Sveriges Lantbruksuniversitet
- Uppsala Universitet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- dog domestication, mitochondrial DNA, non-synonymous mutations, relaxed selection, gray wolf, coyote, mitochondrial genome evolution, selective breeding, phenotypic variability, genetic diversity
- MeSH terms
- Animals, Animals, Domestic, DNA, Mitochondrial, Dogs, Phylogeny, Likelihood Functions
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