Anterior cingulate cortex in schema assimilation and expression
Open accessAbstract
In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.
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The mPFC is involved in monitoring the degree of consistency between existing schemas and novel information.
“Given the known role of the mPFC in monitoring the contents of memory retrieval 22 , this finding suggests that the mPFC is involved in monitoring the degree of consistency between existing schemas and novel information 1,53,121 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [121]
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- Authors
- Wang, S.-H., Tse, D., & Morris, R. G. M.
- Affiliations
- University of Edinburgh (GB)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-07-16
- Volume
- 19
- Issue
- 8
- Pages
- 315-318
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC3407937
- OpenAlex
- W1971230989
- Cited by
- 106
- References
- 17
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 33 · 2018: 10 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 10 · 2013: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Edge Hill University Research Information Repository (Edge Hill University) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- anterior cingulate cortex, cognitive schemas, paired-associate learning, hippocampal-dependent memory, NMDA receptor, AMPA receptors, synaptic transmission, information updating
- MeSH terms
- Analysis of Variance, Animals, Association Learning, Conditioning, Operant, Cues, Gyrus Cinguli, Hippocampus, Male, Neural Pathways, Reaction Time, Mental Recall, Reward, Time Factors, 2-Amino-5-phosphonovalerate, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Rats, Early Growth Response Protein 1
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