Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference
Open accessAbstract
Persistent drug seeking/taking behavior involves the consolidation of memory. With each drug use, the memory may be reactivated and reconsolidated to maintain the original memory. During reactivation, the memory may become labile and susceptible to disruption; thus, molecules involved in plasticity should influence acquisition and/or reconsolidation. Recently, matrix metalloproteinases (MMPs) have been shown to influence neuronal plasticity, presumably by their regulation of extracellular matrix (ECM) molecules involved in synaptic reorganization during learning. We hypothesized that inhibition of MMP activity would impair the acquisition and/or reconsolidation of cocaine-conditioned place preference (CPP) in rats. Intracerebral ventricular (i.c.v.) microinjection of a broad spectrum MMP inhibitor, FN-439, prior to cocaine training suppressed acquisition of CPP and attenuated cocaine-primed reinstatement in extinguished animals. In a separate experiment, the cocaine memory was reactivated on two consecutive days with a cocaine priming injection. On these two days, artificial cerebral spinal fluid (aCSF) or FN-439 was administered either 30 min prior to or 1 min after cocaine-primed reinstatement sessions. Infusion of FN-439 partially impaired retrieval of the cocaine-associated context when given 30 min prior to cocaine. In both groups, however, FN-439 suppressed reinstatement compared with controls on the third consecutive test for cocaine-primed reinstatement, when no FN-439 was given. Control experiments demonstrated that two injections of FN-439 + cocaine given in the home cage, or of FN-439 + saline priming injections in the CPP chambers did not disrupt subsequent cocaine-primed reinstatement. These results show for the first time that (1) MMPs play a critical role in acquisition and reconsolidation of cocaine-induced CPP, and (2) rats demonstrate apparent disruption of reconsolidation by an MMP inhibitor after extinction and while they are under the influence of cocaine during reinstatement.
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Multi-component sleep and circadian programs improve psychiatric outcomes when practiced at biologically suitable times, with phase-sleep coupling mediating symptom change and durability.
“Multi-component sleep and circadian programs improve psychiatric outcomes when practiced at biologically suitable times, with phase-sleep coupling mediating symptom change and durability from youth cohorts to depressive disorders [243,347].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [347]
The Abstract and Discussion address matrix metalloproteinase inhibition and cocaine-conditioned place preference in rats, not sleep or circadian interventions. Searches for phase-sleep coupling and for sleep, circadian, and psychiatric outcomes found no passage addressing the attributed claim; no page numbers were available in our copy. (LLM, conf=0.78)
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- Authors
- Brown, T. E., Forquer, M. R., Cocking, D. L., Jansen, H. T., Harding, J. W., & Sorg, B. A.
- Affiliations
- Washington State University (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-03
- Volume
- 14
- Issue
- 3
- Pages
- 214-223
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC1838561
- OpenAlex
- W2139478464
- Cited by
- 121
- References
- 73
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 14 · 2014: 9 · 2013: 5 · 2012: 15
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Washington State University
- National Institutes of Health (5r21da014915-02)
- National Institute on Drug Abuse (DA 14915)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- matrix metalloproteinases, cocaine, conditioned place preference, memory reconsolidation, memory acquisition, reinstatement, extinction, matrix metalloproteinase inhibitors, extracellular matrix, synaptic plasticity, drug-seeking behavior, memory retrieval
- MeSH terms
- Animals, Cocaine, Conditioning, Operant, Drug Administration Schedule, Extinction, Psychological, Hippocampus, Hydroxamic Acids, Injections, Intraventricular, Male, Oligopeptides, Reinforcement, Psychology, Rats, Sprague-Dawley, Matrix Metalloproteinases, Rats, Matrix Metalloproteinase Inhibitors
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