Cited by 310Memory and Neural MechanismsNeural dynamics and brain functionSleep and Wakefulness Research

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Hippocampal sharp wave bursts coincide with neocortical “up-state” transitions

Open access

Battaglia, Francesco P., Sutherland, Gary R., McNaughton, Bruce L.·2004·Learning & Memory

Open this paper in CoChat — free account Open PDF

Abstract

The sleeping neocortex shows nested oscillatory activity in different frequency ranges, characterized by fluctuations between “up-states” and “down-states.” High-density neuronal ensemble recordings in rats now reveal the interaction between synchronized activity in the hippocampus and neocortex: Electroencephalographic sharp waves in the hippocampus were more probable during down-states than during up-states, and tended to coincide with transitions from down-states to up-states. The form of cortical activity fluctuations and their interactions with sharp waves depend on sleep depth: In deeper sleep stages, characterized by strong neocortical oscillation in the delta range or slower (∼0.8-4 Hz), sharp-wave-triggered peri-event time histograms (PETH) are consistent with a longer duration for down-states than for up-states. In lighter sleep, the sharp-wave-triggered PETH suggested longer up-states than down-states. These results highlight the interplay in the hippocampal/neocortical loop: Decreased neocortical input during down-states may be a factor in generation of sharp waves. In turn, sharp waves may facilitate down-to-up transitions. This interplay may reflect joint memory trace reactivation in the hippocampus and in the neocortex, possibly contributing to consolidation of long-term memory: Off-line reactivation of recent neural activity patterns in the hippocampus occurs during 50-100-msec electroencephalographic sharp waves, corresponding to pyramidal-cell population bursts. The neocortical up-states starting in correspondence with sharp waves may be influenced by the reactivated information carried by the hippocampal sharp wave.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/lm.73504

Cites

0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two-stage model of memory trace formation: A role for “noisy” brain states
Buzsáki, G. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90423-5 · Cited by 1,709
Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states
Destexhe, A., Contreras, D., & Steriade, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04595.1999 · Cited by 573
Long-Lasting Novelty-Induced Neuronal Reverberation during Slow-Wave Sleep in Multiple Forebrain Areas
Ribeiro, S., Gervasoni, D., Soares, E. S., Zhou, Y., Lin, S.-C., Pantoja, J., Lavine, M., & Nicolelis, M. A. L. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020024 · Cited by 272

Flagged first, then by citations

Show all 3 references

Research works printed but not linked: 39

10.1016/S0306-4522(97)00186-3 · DOI
10.1016/0013-4694(77)90258-9 · DOI
2001, Soc. Neurosci. Abs., 27, 643
10.1126/science.1589772 · DOI
1994, J. Neurosci., 14, 6160, 10.1523/JNEUROSCI.14-10-06160.1994 · DOI
1996, J. Neurosci., 16, 3056, 10.1523/JNEUROSCI.16-09-03056.1996 · DOI · Paper page
10.1152/jn.00845.2002 · DOI
1994, J. Neurophysiol., 71, 17, 10.1152/jn.1994.71.1.17 · DOI
10.1016/S0896-6273(00)00135-5 · DOI
10.1126/science.1073538 · DOI · Paper page
10.1002/cne.902950407 · DOI
1999, J. Neurosci., 19, 4090, 10.1523/JNEUROSCI.19-10-04090.1999 · DOI · Paper page
10.1093/cercor/10.12.1168 · DOI
10.1016/S0896-6273(01)00186-6 · DOI · Paper page
10.1126/science.1062856 · DOI · Paper page
1970, Proc. R Soc. Lond. B Biol. Sci., 176, 161, 10.1098/rspb.1970.0040 · DOI
McNaughton, B.L. 1983. Comments in hippocampus symposium panel discussion. In Neurobiology of the hippocampus (ed. W. Siefert), p. 610. Academic Press, New York.
McNaughton, B.L., Barnes, C.A., Battaglia, F.P., Bower, M.R., Cowen, S.L., Ekstrom, A.D., Gerrard, J.L., Hoffman, K.L., Houston, F.P., Karten, Y., et al. 2003. Off-line reprocessing of recent memory and its role in memory consolidation: A progress report. In Sleep and brain plasticity (eds. P. Maquet et al.), pp.225 -246. Oxford University Press, Oxford, UK. · DOI
10.1016/S0006-3495(99)77236-X · DOI
O'Keefe, J. and Nadel, L. 1978. The hippocampus as a cognitive map. Oxford University Press, Oxford.
1989, J. Neurosci., 9, 2907, 10.1523/JNEUROSCI.09-08-02907.1989 · DOI · Paper page
10.1152/jn.01197.2003 · DOI
Percival, D.B. and Walden, A.T. 2002. Spectral analysis for physical applications. Cambridge University Press, Cambridge, UK.
10.1073/pnas.2235811100 · DOI
10.1017/S0048577299971536 · DOI · Paper page
10.1038/79848 · DOI · Paper page
10.1002/(SICI)1098-1063(1996)6:6<685::AID-HIPO11>3.0.CO;2-X · DOI
10.1016/S0896-6273(00)80629-7 · DOI · Paper page
10.1073/pnas.0437938100 · DOI · Paper page
10.1126/science.271.5257.1870 · DOI · Paper page
10.1016/S0306-4522(00)00353-5 · DOI
Steriade, M. and Buzsaki, G. 1990. Parallel activation of thalamic and cortical neurons by brainstem and basal forebrain cholinergic systems. In Brain cholinergic systems (eds. M. Steriade and D. Biesold), pp. 3-64. Oxford University Press, Oxford, UK. · DOI
1993, J. Neurosci., 13, 3252, 10.1523/JNEUROSCI.13-08-03252.1993 · DOI · Paper page
10.1038/81756 · DOI · Paper page
10.1016/S0959-4388(00)00079-9 · DOI · Paper page
10.1073/pnas.041430398 · DOI
10.1016/0006-8993(81)90211-0 · DOI
10.1126/science.8036517 · DOI · Paper page
Zilles, K. 1985. The cortex of the rat. Springer-Verlag, New York. · DOI

Sorted by citations

Items 201–272 of 272

Initiation of sleep-dependent cortical-hippocampal correlations at wakefulness-sleep transition
Haggerty, D. C., & Ji, D. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00783.2013 · Cited by 11
“These observations were consistent with previous studies (Battaglia et al. 2004; Ji and Wilson 2007).”
Result
Sleep-Stage Correlates of Hippocampal Electroencephalogram in Primates
Tamura, R., Nishida, H., Eifuku, S., Fushiki, H., Watanabe, Y., & Uchiyama, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082994 · Cited by 11
Fast network oscillations in the hippocampus
Maier, N., Draguhn, A., Schmitz, D., & Both, M. (2013) · e-Neuroforum · doi:10.1007/s13295-013-0038-0 · Cited by 5
Hippocampal Sharp Wave/Ripple Complexes—Physiology and Mechanisms
Maier, N., & Kempter, R. (2017) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-319-45066-7_14 · Cited by 8
Cholinergic switch between two different types of slow waves in cerebral cortexPreprint
Nghiem, T., Tort-Colet, N., Górski, T., Ferrari, U., Moghimyfiroozabad, S., Goldman, J. S., Teleńczuk, B., Capone, C., Bal, T., di Volo, M., et al. (2018) · bioRxiv · doi:10.1101/430405 · Cited by 9
Hippocampal gamma‐slow oscillation coupling in macaques during sedation and sleep
Richardson, A. G., Liu, X., Weigand, P. K., Hudgins, E. D., Stein, J. M., Das, S. R., Proekt, A., Kelz, M. B., Zhang, M., der Spiegel, J. V., et al. (2017) · Hippocampus · doi:10.1002/hipo.22757 · Cited by 10
“SWRs are biased to occur during neocortical UP states (Battaglia et al., 2004; Molle et al., 2006), which may facilitate both remote replay of HIPP spiking sequences in the neocortex and, ultimately, memory consolidation (Ji and Wilson, 2007).”
Background
Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy
Ouedraogo, W. D., Lenck‐Santini, P., Marti, G., Robbe, D., Crépel, V., & Epsztein, J. (2016) · eNeuro · doi:10.1523/eneuro.0017-16.2016 · Cited by 9
Contribution of a single CA3 neuron to network synchrony
Mikkonen, J., Huttunen, J., & Penttonen, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.007 · Cited by 9
Electrophysiological insights into Alzheimer's disease: A review of human and animal studies
Calvin, K., McNeela, A. M., Osse, A. M. L., Bhasin, G., Ridenour, M., Kinney, J. W., & Hyman, J. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105987 · Cited by 8
Theta-band phase locking during encoding leads to coordinated entorhinal-hippocampal replay
Santos-Pata, D., Barry, C., & Ólafsdóttir, H. F. (2023) · Current Biology · doi:10.1016/j.cub.2023.09.011 · Cited by 10
The Emergent Engram: A Historical Legacy and Contemporary Discovery
Devan, B. D., Berger, K., & McDonald, R. J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00168 · Cited by 8
“empirically somewhere within association cortex, thought to be the repository of long-term memory (Battaglia et al., 2004; Dash et al., 2004; Rauchs et al., 2005; Girardeau et al., 2009; Wang and Morris, 2010; Insel and Takehara-Nishiuchi, 2013; Wiltgen and Tanaka, 2013; de Voogd et al., 2016; Sekeres et al., 2018).”
Background
Neurophysiological Mechanisms of Sleep-Dependent Memory Consolidation and Its Facilitation by Prenatal Choline Supplementation
Cheng, R. (2009) · The Chinese Journal of Physiology · doi:10.4077/cjp.2009.amh085 · Cited by 5
Distinction between slow waves and delta waves sheds light to sleep homeostasis and their association to hippocampal sharp waves ripplesPreprint
El-Kanbi, K., de Lavilléon, G., Bagur, S., Lacroix, M., & Benchenane, K. (2022) · bioRxiv · doi:10.1101/2022.12.27.522034 · Cited by 7
“Interaction between hippocampal SWRs and the slow waves There are now strong pieces of evidence showing that the occurrence of hippocampal SWR and delta waves or down states are not independent.”
ResultInfluential
Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Large-Scale Sleep RhythmPreprint
Šanda, P., Malerba, P., Jiang, X., Krishnan, G., Cash, S., Halgren, E., & Bazhenov, M. (2019) · bioRxiv · doi:10.1101/568881 · Cited by 7
“Another common reference points of the SO are transitions between Up and Down states; it was reported that SWRs commonly follow transition from Down to Up state in the cortical network [Sirota et al., 2003, Battaglia et al., 2004, Isomura et al., 2006, M¨olle et al., 2006].”
Background
Spatio-temporal organization of cell assemblies in Nucleus Reuniens during slow oscillations
Angulo-García, D., Ferraris, M., Ghestem, A., Nallet-Khosrofian, L., Bernard, C., & Quilichini, P. (2018) · bioRxiv · doi:10.1101/474973 · Cited by 7
Neural mechanisms of vocal imitation: The role of sleep replay in shaping mirror neurons
Giret, N., Edeline, J., & Negro, C. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.051 · Cited by 12
Prefrontal-Hippocampal Interactions
Wierzynski, C. (2009) · doi:10.7907/z9833q10 · Cited by 7
Memory consolidation in fragmented sleep
Barner, C., Ngo, H., Diekelmann, S., Weeß, H.-G., & Schlarb, A. (2016) · Somnologie · doi:10.1007/s11818-016-0041-0 · Cited by 6
Associative Reactivation of Place–Reward Information in the Hippocampal–Ventral Striatal Circuitry
Lansink, C. S., & Pennartz, C. M. A. (2014) · Springer series in computational neuroscience · doi:10.1007/978-1-4939-1969-7_4 · Cited by 4
Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice
Brécier, A., Gaëlle, M., Jarzębowski, P., Li, Y., Paulsen, O., & Hay, Y. A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2503139122 · Cited by 3
“This dialogue is thought to occur when hippocampal sharp-wave ripple (SWR) oscillations (120-200 Hz) are coordinated with neocortical slow oscillations (0.5 – 2 Hz) and thalamocortical spindles (10-16 Hz) 4–9 .”
Influential
Offline orbitofrontal cortex reactivation depends on recency of place-reward changes and coheres with hippocampal replay
Rusu, S. I., Bos, J. J., Marchesi, P., Lankelma, J. V., Pica, I. F., Gentet, L. J., Joëls, M., & Pennartz, C. M. A. (2024) · iScience · doi:10.1016/j.isci.2024.109205 · Cited by 7
“85 However, this paradox may be explained by OFC-hippocampal coac-tivitybeingcoordinatedbyothermechanismsthanthosedirectlydependingonSWRs,whileitisalsorelevanttorecallthattheActivestatesas deﬁned here are not identical to Up states.”
Background
Combining Cortical Voltage Imaging and Hippocampal Electrophysiology for Investigating Global, Multi-Timescale Activity Interactions in the Brain
Pedrosa, R., Song, C.-C., Knöpfel, T., & Battaglia, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23126814 · Cited by 5
“Microelectrode techniques, on the other hand, provide recordings with excellent temporal resolution but limited spatial information [12].”
BackgroundSelf-citation
Human REM Sleep Delta Waves and the Blurring Distinction between NREM and REM Sleep
Langille, J. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0480-19.2019 · Cited by 7
“Bi-stable neuronal activity patterns with depolarized “on-” and hyperpolarized “off-” states give rise to delta waves and are thought to enable NREM sleep to function in memory consolidation (Battaglia et al., 2004) and synaptic homeostasis (Tononi and Cirelli, 2014).”
Background
Excitable dynamics of NREM sleep: a unifying model for neocortex and hippocampus
Levenstein, D., Buzsáki, G., & Rinzel, J. (2018) · bioRxiv · doi:10.1101/312587 · Cited by 5
Sleep EEG Rhythms and System Consolidation of Memory
Feld, G. B., & Jan Born, A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384995-3.00009-5 · Cited by 6
MMP-2/9 inhibition modulates sharp wave abundance, inhibitory proteoglycan sulfation, and fear memory in juvenile zebrafish: relevance to affective disorders
Blanco, I., Deasy, S., Amontree, M., Gabriel, M., Caccavano, A., Vicini, S., Glasgow, E. F., & Conant, K. E. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03007-y · Cited by 7
“%) of sharp wave (SW) events contain an embedded ripple (SWR) event [35], and that the abundance of SW and SWRs typically follows the same directionality, we focused on MMP-2/9-modulation of SW events, also crucial for learning and memory [53 – 55].”
Learning-dependent gating of hippocampal inputs by frontal interneurons
Zhang, C.-L., Sontag, L., Gómez-Ocádiz, R., & Schmidt‐Hieber, C. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2403325121 · Cited by 3
Hippocampal ripples coincide with “up-state” and cortical spindles in Retrosplenial CortexPreprint
Pedrosa, R., Nazari, M., Kergoat, L., Bernard, C., Mohajerani, M. H., Stella, F., & Battaglia, F. (2022) · bioRxiv · doi:10.1101/2022.12.19.521088 · Cited by 3
“…et al., 2009), 2) the suppression sleep SWR impairs memory performance (Girardeau et al., 2009; Maingret et al., 2016), and 3) SWRs are coupled to the active, UP-state of Slow Oscillation (SO; <1Hz) in specific associative areas in the neocortex (Battaglia et al., 2004; Sirota et al., 2003).”
BackgroundSelf-citation
Biophysical and network mechanisms of high frequency extracellular potentials in the rat hippocampus
Schomburg, E. W. (2014) · doi:10.7907/7txg-7m48 · Cited by 3
Electrophysiological Mechanisms of Network Control
Valiante, T. A., & Carlen, P. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-415804-7.00009-5 · Cited by 4
Spatial Decisions and Neuronal Activity in Hippocampal Projection Zones in Prefrontal Cortex and Striatum
Battaglia, F. P., Peyrache, A., Khamassi, M., & Wiener, S. I. (2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195323245.003.0021 · Cited by 3
“Using an extensive array of electrodes covering a large portion of the rat neocortex, Battaglia et al. (2004) demonstrated that up and down states are characterized by a large degree of coherence across the entire neocortex, with virtually all cortical neurons shutting down during a down state and…”
BackgroundMethodSelf-citation
Spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity
Choudhary, K., Berberich, S., Hahn, T. T. G., McFarland, J. M., & Mehta, M. R. (2024) · Nature Communications · doi:10.1038/s41467-024-47617-6 · Cited by 5
Oscillatory-Quality of sleep spindles: from properties to functionPreprint
Blanco-Duque, C., Bond, S. A., Krone, L., Dufour, J.-P., Gillen, E. C. P., Kahn, M., Purple, R., Bannerman, D., Mann, E., Achermann, P., et al. (2023) · bioRxiv · doi:10.1101/2023.06.28.546981 · Cited by 2
A High Performance, Inexpensive Setup for Simultaneous Multisite Recording of Electrophysiological Signals and Wide-Field Optical Imaging in the Mouse CortexPreprint
Contreras, E. B., Chekhov, S., Tarnowsky, J., Sun, J., McNaughton, B., & Mohajerani, M. H. (2017) · bioRxiv · doi:10.1101/177188 · Cited by 2
“…2014; Manita et al. 2015), in memory, in which sharp-wave events at a local hippocampal circuit might be related to more global cortical activity (Battaglia et al. 2004) or in cortical processing in general, as a mean to quantify neuronal ‘population coupling’ or ‘packet-based communication’…”
BackgroundSelf-citation
UP-DOWN cortical dynamics reflect state transitions in a bistable balanced network
Jercog, D., Roxin, A., Barthó, P., Luczak, A., Compte, A., & de la Rocha, J. (2016) · bioRxiv · doi:10.1101/083626 · Cited by 2
“…can generate more complex UP-DOWN patterns than the isolated cortex, with subcortical activity in many areas correlating with transition times (Battaglia et al., 2004; Crunelli et al., 2015; Crunelli and Hughes, 2010; David et al., 2013; Lewis et al., 2015; Slézia et al., 2011; Ushimaru et…”
BackgroundInfluential
Caracterização eletrofisiológica da circuitaria hipocampal durante o ciclo sono-vigília do rato
Schenberg, E. E. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.47.2010.tde-08092010-144121
Model of Balance of Excitation and Inhibition in Hippocampal Sharp Wave Replays and Application to Spatial Remapping
Ponzi, A. P. D. (2007) · IEEE International Conference on Neural Networks/IEEE ... International Conference on Neural Networks · doi:10.1109/ijcnn.2007.4371329 · Cited by 2
“Furthermore hippocampal sharp wave bursts coincide with neocortical "up-state" transitions[24].”
Background
Going Beyond a Mean-field Model for the Learning Cortex: Second-Order Statistics
Wilson, M. T., Steyn‐Ross, M. L., Steyn‐Ross, D. A., & SLEIGH, J. W. (2007) · Journal of Biological Physics · doi:10.1007/s10867-008-9056-5 · Cited by 3
“Experimentally, Battaglia et al. have reported that electroencephalographic sharp waves from the hippocampus are correlated with the down–up transition of slow-wave sleep, suggestive of a role for slow waves in long-term memory [ 47 ].”
Background
Hippocampal Information Processing and Homeostatic Regulation During REM and Non-REM Sleep
Mizuseki, K., & Miyawaki, H. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00004-9 · Cited by 2
The Role of Sleep in Memory Consolidation: Active or Permissive?
Schönauer, M., & Jan Born, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21034-1 · Cited by 4
The Cognitive Psychology of Sleep and Memory
Alger, S. E., Pardilla‐Delgado, E., Mattingly, S. M., Cunningham, T. J., & Payne, J. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21062-6 · Cited by 4
Hippocampal neural firing dynamics during sleep
Grosmark, A. (2014) · doi:10.7282/t3k072j1 · Cited by 1
Cortical GABAergic inhibition dynamics around hippocampal sharp-wave ripplesPreprint
Rezaei, E., Tohidi, S., Nazari, M., McNaughton, B. L., & Mohajerani, M. H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.17.670701 · Cited by 1
“Other studies showed that hippocampal sharp-wave ripple bursts occurred around the time when the cortex entered an active “up-state” and could influence cortical population activity, suggesting that hippocampal activity can also shape cortical dynamics 20 .”
Self-citation
Cognitive Algorithms and Systems of Episodic Memory, Semantic Memory, and Their Learnings
Zhang, Q. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1452-1_13
“Such synchronization is attributed to be the evidence of memory consolidation from the hippocampus into the neocortex (Battaglia, et al., 2004).”
The default mode network during sleep: spindle oscillations and long-range cortical interactions in memory consolidation
Stella, F., & Battaglia, F. P. (2025) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2025.101606
Self-citation
Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex
Saxena, R., Shobe, J. L., Andujo, A. M., Ning, W., Anaclet, C., & McNaughton, B. L. (2025) · bioRxiv · doi:10.1101/2025.09.01.673156 · Cited by 1
Self-citation
Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model
Potesta, C. V., Cargile, M., Yan, A., Xiong, S., Macdonald, R. L., Gallagher, M. J., & Zhou, C. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf187 · Cited by 1
“Meanwhile, during NREM sleep, cortical neurons within thalamocortical cir - cuitry exhibit up/down-state alterations (Shu et al.2003,Battaglia et al. 2004, Dehghani et al. 2016, Levenstein et al. 2017, Niethard et al. 2018, Tukker et al. 2020, Cary and Turrigiano 2021, Torao-Angosto et…”
Cortical Reactivation of Non-Spatial and Spatial Memory Representations Coordinate with Hippocampus to Form a Memory Dialogue
Chang, H.-R., Esteves, I. M., Neumann, A. R., Mohajerani, M. H., & McNaughton, B. (2022) · bioRxiv · doi:10.1101/2022.12.16.520658 · Cited by 1
“…populations during offline periods — which are temporally coupled with transient cortical activities (Chrobak and Buzsáki, 1996; Siapas and Wilson, 1998; Kudrimoti et al., 1999; Sirota et al., 2003; Battaglia et al., 2004; Isomura et al., 2006; Wierzynski et al., 2009; Logothetis et al., 2012).”
BackgroundSelf-citation
Effect of learning on slow gamma propagation between hippocampus and cortex in the wild-type and AD mice
Blinowska, K. J., Kamiński, M., Macrez, N., Marighetto, A., Meyrand, P., & Bem, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-26754-2 · Cited by 1
Rapid Spectral Dynamics in Hippocampal Oscillons
Zobaer, M. S., Domenico, C., Perotti, L., Ji, D.-Y., & Dabaghian, Y. (2022) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2022.880742 · Cited by 1
“, wavelet analysis is most appropriate for studying timelocalized events, such as ripples or spindles (Battaglia et al., 2004; Bosnyakova et al., 2006; Sitnikova et al., 2009; Luijtelaar et al., 2011), whereas Fourier decomposition is used for describing the oscillatory patterns of LFPs (Roopun et al.”
BackgroundMethod
Theory of spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity
Choudhary, K., Berberich, S., Hahn, T. T. G., & Mehta, M. (2022) · bioRxiv · doi:10.1101/2022.04.15.488496 · Cited by 1
Inhibition is the hallmark of CA3 intracellular dynamics around awake ripples
Kajikawa, K., Hulse, B., Siapas, A. G., & Lubenov, E. V. (2021) · bioRxiv · doi:10.1101/2021.04.20.440699 · Cited by 1
“Furthermore, awake ripples occurred throughout the UP state and were not concentrated near the DOWN→UP transitions (Battaglia et al., 2004).”
Background
Sleep and Memory
Alger, S. E., & Payne, J. D. (2018) · Wiley eBooks · doi:10.1002/9781119170174.epcn104 · Cited by 1
Spontaneous Slow Oscillations and Sequential Patterns Due to Short-Term Plasticity in a Model of the Cortex
Leleu, T. G., & Aihara, K. (2013) · Neural Computation · doi:10.1162/neco_a_00513 · Cited by 1
A Biophysical Model of Cortical Up and Down States: Excitatory-Inhibitory Balance and H-Current
Navratilova, Z., & Fellous, J. (2007) · Summer School on Neural Networks · doi:10.1007/978-3-540-88853-6_5 · Cited by 1
“How up states are generated in vivo is still unknown, but it is thought that a pulse of synchronous excitation from the hippocampus [11], thalamus [12] or other cortical neurons may be key.”
Sleep and Brain Plasticity
Frank, M. G. (2019) · Springer eBooks · doi:10.1007/978-981-13-2814-5_5 · Cited by 5
Biasing neural activity: Entrainment of cortical neurons by applied electric fields
Ozen, S. (2010) · doi:10.7282/t32b8xt4 · Cited by 1
“Increased synchrony in neocortical-hippocampal networks might have led to an improvement in memory consolidation (Siapas and Wilson, 1998; Sirota et al., 2003; Battaglia et al., 2004).”
Background
Sleep Spindles and Slow Oscillations as Potential Biomarkers and Therapeutic Targets in Mild-to-Moderate Alzheimer’s Disease
Páez, A., Piñol‐Ripoll, G., Dakterzada, F., & Dang-Vu, T. T. (2026) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-026-01528-9
“The temporal coordination of SOs with thalamocorti - cal spindles and hippocampal ripples is thought to support the transfer and integration of newly encoded memories [ 35, 36 ].”
Hippocampal–Cortical Circuits and Memory
Liu, C., Harvey, R. E., & Fernández‐Ruiz, A. (2026) · The Neuroscientist · doi:10.1177/10738584261469147
Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidationPreprint
Vöröslakos, M., Lafferty, C. K., Zheng, Z., Paleologos, N., Chinigò, E., McClain, K., Aykan, D., Yoon, E., & Buzsáki, G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.27.714843
Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations
Swanson, R., Chinigò, E., Levenstein, D., Vöröslakos, M., Mousavi, N., Wang, X.-J., Basu, J., & Buzsáki, G. (2024) · bioRxiv · doi:10.1101/2024.10.23.619879
“An unexpected observation, in light of previous claims [14], [17], [18], was the absence of SWRs preceding and thus putatively inducing UP states.”
BackgroundResultInfluential
Preoptic area controls sleep-related seizure onset in a genetic epilepsy mouse model
Potesta, C. V., Cargile, M. S., Yan, A., Xiong, S., Macdonald, R. L., Gallagher, M. J., & Zhou, C.-W. (2024) · bioRxiv · doi:10.1101/2023.11.24.568593
“At the same time, during sleep, cortical neurons within thalamocortical circuitry exhibit up/down-state alteration 7,33-40 .”
Background
Rapid runtime learning by curating small datasets of high-quality items obtained from memory
German, J., Cui, G., Xu, C., & Jacobs, R. A. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011445
Brain state-dependent cortico-hippocampal network dynamics are modulated by postnatal stimuliPreprint
Shinohara, Y., Koketsu, S., Hirase, H., & Ueki, T. (2020) · bioRxiv · doi:10.1101/2020.12.25.424297
“While the modulation of cortico-hippocampal dynamics after memory acquisition is outside the scope of this paper, examination of post-SWR co-activation of various cortical areas will be valuable (Battaglia et al., 2004; Wang and Ikemoto, 2016).”
Background
Replay of large-scale spatio-temporal patterns from waking during subsequent slow-wave sleep in human cortex
Jiang, X., Shamie, I., Doyle, W., Friedman, D., Dugan, P. C., Devinsky, O., Eskandar, E., Cash, S., Thesen, T., & Halgren, E. (2017) · bioRxiv · doi:10.1101/221275
System identification for sleep-mediated, stimulation-enhanced memory consolidation
Lepage, K., & Vijayan, S. (2017) · Asilomar Conference on Signals, Systems and Computers · doi:10.1109/acssc.2017.8335196
“Experimental work has shown that there is coordination between these oscillations [3, 24, 32, 33] and that sequences of neuronal activation that occur during awake behavior are reactivated during subsequent sleep in the hippocampus [22, 34, 38] and the neocortex [20] during these oscillatory events.”
Background
Response to ‘Hippocampus as a wormhole: gateway to consciousness’
Faw, M., & Faw, B. (2017) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1447
Role of interneuronal systems in the formation of main patterns of field electrical activity in the hippocampus
Markova, O., Tsugorka, T. M., Dovgan’, A. V., Stepanyuk, A. R., & Cherkas, V. (2008) · Neurophysiology · doi:10.1007/s11062-008-9014-7
Propagation of Hippocampal Ripples to the Neocortex by Way of a Subiculum-Retrospleanial PathwayPreprint
Nitzan, N., McKenzie, S., English, D., Beed, P., Oldani, S., Tukker, J. J., Buzsáki, G., & Schmitz, D. (2019) · Social Science Research Network · doi:10.2139/ssrn.3381954
Neural Synchrony and Memory In and Out of Sleep
Benchenane, K., & Peyrache, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21117-6 · Cited by 1
Inter-regional synchronization in the hippocampal system by oscillations
Sullivan, D. W. (2013) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t33n221m
“oscillation, dominant during slow wave sleep (Steriade et al., 1993; Sirota et al., 2003; Isomura et al., 2006; Battaglia et al., 2004).”
Dream Therapy: Correlation of Dream Contents with Encephalographic and Cardiovascular Activations
da Rosa, A. C., & Rodrigues, J. (2011) · The frontiers collection · doi:10.1007/978-3-642-18047-7_5
“During REM after procedural task learning, the firing sequence of hippocampal neurons seemed similar to that of the task learning phase ( Battaglia et al. 2004 ).”
Result

Authors: Battaglia, F. P., Sutherland, G. R., & McNaughton, B. L.
Affiliations: University of Arizona (US)
Centre National de la Recherche Scientifique (FR)
ORCID: Battaglia, Francesco P.
McNaughton, Bruce L.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2004-11
Volume: 11
Issue: 6
Pages: 697-704
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.73504
PMC: PMC534698
OpenAlex: W1986823100
Cited by: 310
References: 43
Citations by year: 2026: 2 · 2025: 15 · 2024: 14 · 2023: 11 · 2022: 17 · 2021: 13 · 2020: 19 · 2019: 14 · 2018: 17 · 2017: 25 · 2016: 20 · 2015: 14 · 2014: 16 · 2013: 13 · 2012: 10
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH046823, R37MH046823)
National Institute of General Medical Sciences (T32GM008400)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: sleep, hippocampal-neocortical interaction, sleep depth, delta oscillations, memory consolidation
MeSH terms: Animals, Cortical Synchronization, Electroencephalography, Hippocampus, Membrane Potentials, Neural Pathways, Neurons, Sleep, Neocortex, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hippocampal sharp wave bursts coincide with neocortical “up-state” transitions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks