Coordinated Reactivation of Distributed Memory Traces in Primate Neocortex
Abstract
Conversion of new memories into a lasting form may involve the gradual refinement and linking together of neural representations stored widely throughout neocortex. This consolidation process may require coordinated reactivation of distributed components of memory traces while the cortex is "offline," i.e., not engaged in processing external stimuli. Simultaneous neural ensemble recordings from four sites in the macaque neocortex revealed such coordinated reactivation. In motor, somatosensory, and parietal cortex (but not prefrontal cortex), the behaviorally induced correlation structure and temporal patterning of neural ensembles within and between regions were preserved, confirming a major tenet of the trace-reactivation theory of memory consolidation.
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Reactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior.
“Reactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior like explo-ration or running in a maze (191, 268, 556, 673, 870; see Ref. 175 for a review).”
From About Sleep's Role in Memory (2013) · cites this paper as [556]
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- Authors
- Hoffman, K. L., & McNaughton, B. L.
- Affiliations
- University of Arizona (US)
- Corresponding author
- McNaughton, B. L.
- Venue
- Science
- Published
- 2002-09-20
- Volume
- 297
- Issue
- 5589
- Pages
- 2070-2073
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972053361
- Cited by
- 420
- References
- 5
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 22 · 2018: 15 · 2017: 18 · 2016: 19 · 2015: 15 · 2014: 34 · 2013: 20 · 2012: 22
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh001565-02)
- National Institute of Mental Health (MH01565)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- memory consolidation, neuronal ensembles, motor cortex, somatosensory cortex, parietal cortex, prefrontal cortex, primate neocortex
- MeSH terms
- Action Potentials, Animals, Brain Mapping, Cues, Electrodes, Implanted, Macaca mulatta, Male, Memory, Motor Cortex, Neurons, Parietal Lobe, Mental Recall, Somatosensory Cortex, Time Factors, Prefrontal Cortex, Neocortex
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