Cited by 420Memory and Neural MechanismsSleep and Wakefulness ResearchNeural dynamics and brain function

Coordinated Reactivation of Distributed Memory Traces in Primate Neocortex

Hoffman, K. L., McNaughton, B. L.·2002·Science

Abstract

Conversion of new memories into a lasting form may involve the gradual refinement and linking together of neural representations stored widely throughout neocortex. This consolidation process may require coordinated reactivation of distributed components of memory traces while the cortex is "offline," i.e., not engaged in processing external stimuli. Simultaneous neural ensemble recordings from four sites in the macaque neocortex revealed such coordinated reactivation. In motor, somatosensory, and parietal cortex (but not prefrontal cortex), the behaviorally induced correlation structure and temporal patterning of neural ensembles within and between regions were preserved, confirming a major tenet of the trace-reactivation theory of memory consolidation.

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Crossref · 10.1126/science.1073538

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  • Reactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior.

    “Reactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior like explo-ration or running in a maze (191, 268, 556, 673, 870; see Ref. 175 for a review).”

    From About Sleep's Role in Memory (2013) · cites this paper as [556]

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Authors
Hoffman, K. L., & McNaughton, B. L.
Affiliations
University of Arizona (US)
Corresponding author
McNaughton, B. L.
Venue
Science
Published
2002-09-20
Volume
297
Issue
5589
Pages
2070-2073
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1972053361
Cited by
420
References
5
Citations by year
2026: 10 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 22 · 2018: 15 · 2017: 18 · 2016: 19 · 2015: 15 · 2014: 34 · 2013: 20 · 2012: 22
FWCI
8.75
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k05mh001565-02)
  • National Institute of Mental Health (MH01565)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
memory consolidation, neuronal ensembles, motor cortex, somatosensory cortex, parietal cortex, prefrontal cortex, primate neocortex
MeSH terms
Action Potentials, Animals, Brain Mapping, Cues, Electrodes, Implanted, Macaca mulatta, Male, Memory, Motor Cortex, Neurons, Parietal Lobe, Mental Recall, Somatosensory Cortex, Time Factors, Prefrontal Cortex, Neocortex

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