Arabidopsis JAGGED LATERAL ORGANS Acts with ASYMMETRIC LEAVES2 to Coordinate KNOX and PIN Expression in Shoot and Root Meristems
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Organ initiation requires the specification of a group of founder cells at the flanks of the shoot apical meristem and the creation of a functional boundary that separates the incipient primordia from the remainder of the meristem. Organ development is closely linked to the downregulation of class I KNOTTED1 LIKE HOMEOBOX (KNOX) genes and accumulation of auxin at sites of primordia initiation. Here, we show that Arabidopsis thaliana JAGGED LATERAL ORGANS (JLO), a member of the LATERAL ORGAN BOUNDARY DOMAIN (LBD) gene family, is required for coordinated organ development in shoot and floral meristems. Loss of JLO function results in ectopic expression of the KNOX genes SHOOT MERISTEMLESS and BREVIPEDICELLUS (BP), indicating that JLO acts to restrict KNOX expression. JLO acts in a trimeric protein complex with ASYMMETRIC LEAVES2 (AS2), another LBD protein, and AS1 to suppress BP expression in lateral organs. In addition to its role in KNOX regulation, we identified a role for AS2 in regulating PINFORMED (PIN) expression and auxin transport from embryogenesis onwards together with JLO. We propose that different JLO and AS2 protein complexes, possibly also comprising other LBD proteins, coordinate auxin distribution and meristem function through the regulation of KNOX and PIN expression during Arabidopsis development.
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JLO is expressed at the boundary between the SAM and organ primordia.
“JLO is expressed at the boundary between the SAM and organ primordia (Borghi et al., 2007;Bureau et al., 2010;Rast & Simon, 2012)”
From <i>Divide et impera</i>: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Rast & Simon, 2012
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TWI1 regulates cell‐to‐cell movement of OSH15 to control leaf cell fate
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Emerging Role of the Ubiquitin Proteasome System in the Control of Shoot Apical Meristem FunctionF
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Overexpression of TaLBD16-4D alters plant architecture and heading date in transgenic wheat
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Origin, Development and Differentiation of Leaves
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Functional Analysis of the miR156 Regulatory Network in Arabidopsis Siliques
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- Authors
- Rast, M. I., & Simon, R.
- Affiliations
- Institut für Entwicklungsgenetik, Heinrich-Heine-Universität, 40225 Duesseldorf, Germany
- Heinrich Heine University Düsseldorf (DE)
- ORCID
- Simon, Rüdiger
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07
- Volume
- 24
- Issue
- 7
- Pages
- 2917-2933
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- PMC
- PMC3426123
- OpenAlex
- W2113083753
- Cited by
- 89
- References
- 50
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 11 · 2016: 5 · 2015: 12 · 2014: 8 · 2013: 12 · 2012: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Plant Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- ASYMMETRIC LEAVES2, AS1, SHOOT MERISTEMLESS, auxin transport, auxin distribution, organ initiation, shoot apical meristem, floral meristem, root meristem, founder cells, Arabidopsis thaliana
- MeSH terms
- Alleles, Biological Transport, Indoleacetic Acids, Models, Molecular, Mutation, Phenotype, Repressor Proteins, Transcription Factors, Down-Regulation, Up-Regulation, Arabidopsis, Protein Structure, Tertiary, Gene Expression Regulation, Plant, Plant Roots, Meristem, Gene Dosage, Protein Interaction Mapping, Arabidopsis Proteins, Plant Components, Aerial, Seedlings, Protein Multimerization
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